Development of a High SAR Conformal Antenna for Hyperthermia Tumors Treatment

Koo, Yun Seo; Kazemi, Robab; Liu, Quanhua; Phillips, Jeffrey; Fathy, Aly E.

doi:10.1109/tap.2014.2357419

Cited by 32 publications

(6 citation statements)

References 34 publications

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“… 10 - 13 As a promising nanobiomaterial, Au nanoscale particles show efficient local heating upon excitation of surface plasmon oscillations and have been widely studied as photothermal agents for cancer therapy, 14 - 16 as traditional hyperthermia treatments typically lack specificity for the tumor. 17 , 18 Chemo-photothermal therapy provides a convenient and efficient way to combine the advantages of chemo- and thermal therapeutic effects. Huiyul Park et al developed drug-loaded poly(lactic-co-glycolic acid)-Au half-shell nanoparticles for the tumor-specific delivery of heat and drugs 15 these particles were prepared by spin-casting aqueous suspensions of NPs onto a silicon substrate.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy

Sun¹,

Wang²,

Chen³

et al. 2017

Theranostics

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Gold nanoparticle-coated Pluronic-b-poly(L-lysine) nanoparticles (Pluronic-PLL@Au NPs) were synthesized via an easy one-step method and employed as carriers for the delivery of paclitaxel (PTX) in chemo-photothermal therapy, in which Pluronic-PLL acts as the reductant for the formation of AuNPs without the need for an additional reducing agent. Methods: The deposition of AuNPs on the surface of Pluronic-PLL micelles and the thermal response of the system were followed via ultraviolet-visible spectroscopy and dynamic light scattering. Calcein-AM and MTT assays were used to study the cell viability of MDA-MB-231 cells treated with PTX-loaded Pluronic-PLL@Au NPs, and we then irradiated the cells with NIR light. Results: An obvious temperature response was observed for the Pluronic-PLL@Au NPs. Blood compatibility and in vitro cytotoxicity assays confirmed that the Pluronic-PLL@Au NPs have excellent biocompatibility. Compared to Taxol, the PTX-loaded Pluronic-PLL@Au NPs exhibited higher cytotoxicity in MDA-MB-231 cells. All of these results and confocal laser scanning microscopy analysis results suggest that Pluronic-PLL@Au NPs greatly enhance the cellular uptake efficiency of the drug. Conclusion: As confirmed by in vitro and in vivo studies, the combination of chemotherapy and photothermal therapy can cause more damage than chemo- or photothermal therapy did alone, demonstrating the synergistic effect of chemo-photothermal treatment. Thus, the as-prepared Pluronic-PLL@Au NPs are promising for chemo-photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy

Sun¹,

Wang²,

Chen³

et al. 2017

Theranostics

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“…Water Bolus as a cooling device, it is used to prevent skin damage in many of the available equipment in hyperthermia applicators. But it causes adverse effects on antenna radiations [31].…”

Section: Antenna Designmentioning

confidence: 99%

Design and Simulation of Non-Invasive Microwave Antenna for Hyperthermia Lipolysis Scheme

Elnady

Rahouma

Ali

2022

Journal of Advanced Engineering Trends

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A Non-invasive hyperthermia ablation technique of adipose tissue using a microwave is proposed. It uses dielectric heating to heat the adipose tissue using a rectangular Horn antenna. A selection of operating frequency 5.8 GHz, as an industrial, scientific, and medical radio bands (ISM band), for concentrating electromagnetic (EM) power radiated from the external antenna to the adipose tissue. To protect skin from heat, a silicon layer is used on the surface of the skin instead of water bolus to reduce the percentage of burns on the skin surface. The performance of this antenna is applied in three biological tissues (skin, fat, and muscles), using the simulation of computer simulation technology (CST) microwave studio. The main feature in this antenna is the centralization of the Specific absorption rate (SAR) at the fat tissue more than other tissues. Finally, results achieved good matching of the return loss (S11), and linear SAR value became high at fat tissue more than other tissues, and also the temperature distribution inside fat tissues became 42.7 °C while keeping the temperature inside the skin and muscles below 40 °C after 30 minutes.

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“…The newly studied rehabilitation system is the resonant cavity created in previous studies for the treatment of profound hyperthermia. Experimental results using phantom agar showed that our heating system is able to heat deep tissue inside the knee without physical contact with the surface [6][7][8].…”

Section: Introductionmentioning

confidence: 98%

Design, Optimization and Simulation of Knee Pain Relief Device Using Hyperthermia Technology

Rajabi¹,

Asbagh²,

Askarizadegan³

2020

AJEA

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Hyperthermia has been introduced as a therapeutic method and adjuvant therapy in the treatment of some diseases such as breast and pancreatic cancers. On the other hand, other applications of hyperthermia have been considered. In this article, ways to treat knee pain caused by osteoarthritis, patellar chondromasia, rheumatism, knee infection, etc., have been studied using antenna hyperthermia. For antenna hyperthermia, is using a rectangular microstrip antenna, which is the simplest type of antenna. The antenna considered in this article has conformal conditions and is designed in the shape of a knee structure, to create a suitable knee covering. The antenna considered in this article has conformal conditions and is designed in the shape of a knee structure, to create a suitable knee covering. In addition to the geometric structure of the antenna, which fits the structure of the knee, the resonance frequency of the antenna is in the range of ISM standard frequencies and attempts have been made to place it at 2.4 GHz. On the other hand, to show the thermal pattern created by the antenna, the specific absorption rate of the tissue is investigated and its diagram is simulated by the antenna radiation field.

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Development of a High SAR Conformal Antenna for Hyperthermia Tumors Treatment

Cited by 32 publications

References 34 publications

Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy

Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy

Design and Simulation of Non-Invasive Microwave Antenna for Hyperthermia Lipolysis Scheme

Design, Optimization and Simulation of Knee Pain Relief Device Using Hyperthermia Technology

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