Development of a French Isometric Strength Normative Database for Adults Using Quantitative Muscle Testing

Hogrel, Jean‐Yves; Payán, C.; Ollivier, G.; Tanant, Véronique; Attarian, Shahram; Couillandre, Annabelle; Dupeyron, Arnaud; Lacomblez, Lucette; Doppler, Valérie; Meininger, Vincent; Tranchant, C.; Pouget, Jean; Desnuelle, Claude

doi:10.1016/j.apmr.2007.07.011

Cited by 99 publications

(75 citation statements)

References 23 publications

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“…This function could be a good candidate to assess the impact of a therapeutic intervention. It also presents a good intra‐ and interrater reproducibility 16. As for the MFM, the total score and the D1 showed a moderate change over 4 years.…”

Section: Discussionmentioning

confidence: 82%

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Natural history of LGMD2A for delineating outcome measures in clinical trials

Richard

Hogrel

Stockholm

et al. 2016

Ann Clin Transl Neurol

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ObjectiveLimb‐girdle muscular dystophy 2A (LGMD2A, OMIM) is a slowly progressive myopathy caused by the deficiency in calpain 3, a calcium‐dependent cysteine protease of the skeletal muscle.MethodsIn this study, we carried out an observational study of clinical manifestations and disease progression in genetically confirmed LGMD2A patients for up to 4 years. A total of 85 patients, aged 14–65 years, were recruited in three centers located in metropolitan France, the Basque country, and the Reunion Island. They were followed up every 6 months for 2 years and a subgroup was assessed annually thereafter for two more years. Data collected for all patients included clinical history, blood parameters, muscle strength assessed by manual muscle testing (MMT) and quantitative muscle testing, functional scores, and pulmonary and cardiac functions. In addition, CT scans of the lower limbs were performed in a subgroup of patients.ResultsOur study confirms the clinical description of a slowly progressive disorder with onset in the first or second decade of life with some degree of variability related to gender and mutation type. The null mutations lead to a more severe phenotype while compound heterozygote patients are the least affected. Muscle weakness is remarkably symmetrical and predominant in the axial muscles of the trunk and proximal muscles of the lower limb. There was a high correlation between the weakness at individual muscle level as assessed by MMT and the loss of density in CT scan analysis.InterpretationAll the generated data will help to determine the endpoints for further clinical studies.

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Section: Discussionmentioning

confidence: 82%

“…QMT was performed using fixed dynamometry. Strength values were expressed in percentage of predicted values computed for age, sex, and weight using predictive equations already published 16. This normalization allows computing composite scores in a suitable way.…”

Section: Methodsmentioning

confidence: 99%

Natural history of LGMD2A for delineating outcome measures in clinical trials

Richard

Hogrel

Stockholm

et al. 2016

Ann Clin Transl Neurol

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“…[17][18][19] The purpose of this study was to generate a reference dataset of normative values across the lifespan for an extensive set of isometric muscle strength and joint flexibility items, stratified for age and sex, and to investigate the influence of demographic and anthropometric factors.…”

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confidence: 99%

Normative reference values for strength and flexibility of 1,000 children and adults

et al. 2017

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Objective: To establish reference values for isometric strength of 12 muscle groups and flexibility of 13 joint movements in 1,000 children and adults and investigate the influence of demographic and anthropometric factors.Methods: A standardized reliable protocol of hand-held and fixed dynamometry for isometric strength of ankle, knee, hip, elbow, and shoulder musculature as well as goniometry for flexibility of the ankle, knee, hip, elbow, shoulder, and cervical spine was performed in an observational study investigating 1,000 healthy male and female participants aged 3-101 years. Correlation and multiple regression analyses were performed to identify factors independently associated with strength and flexibility of children, adolescents, adults, and older adults. Results:Normative reference values of 25 strength and flexibility measures were generated.Strong linear correlations between age and strength were identified in the first 2 decades of life. Muscle strength significantly decreased with age in older adults. Regression modeling identified increasing height as the most significant predictor of strength in children, higher body mass in adolescents, and male sex in adults and older adults. Joint flexibility gradually decreased with age, with little sex difference. Waist circumference was a significant predictor of variability in joint flexibility in adolescents, adults, and older adults. Conclusions:Reference values and associated age-and sex-stratified z scores generated from this study can be used to determine the presence and extent of impairments associated with neuromuscular and other neurologic disorders, monitor disease progression over time in natural history studies, and evaluate the effect of new treatments in clinical trials. Neurology ® 2017;88:36-43Meaningful, reliable, and sensitive outcome measures are required to monitor treatment and progression of neuromuscular and other neurologic disorders. While there have been substantial advances in the understanding of the pathogenesis and natural history of many neuromuscular disorders, the identification and development of new outcome measures that best reflect the efficacy of specific treatments have not advanced at the same rate. 1 Establishing valid and responsive outcome measures is a priority for the field. 2 To assist in the development of new outcome measures, normative reference values generated from large populations across the lifespan using standardized methods are required. Normative reference values can be utilized to generate z scores, which can be used in multicenter studies to improve outcome measure precision and responsiveness.Muscle weakness and joint contractures predispose to numerous pathologies requiring intervention. Reference data play an important role in identifying and quantifying these impairments and evaluating the effectiveness of interventions. Currently, few comprehensive datasets detail the normal variation of active range of motion in healthy individuals and are limited by the number of joints assessed, 3...

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“…14 Given the need for continued investigation into the role of lower extremity strength and its association with injury and reinjury, assessment methods need to be both accessible and reliable. Researchers have measured lower extremity muscular strength using various isometric, [15][16][17][18] isotonic, [19][20][21][22] and isokinetic [23][24][25][26] methods. These assessments can further be classified into 3 categories: tertiary, secondary, and primary.…”

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confidence: 99%

The Reliability of Portable Fixed Dynamometry During Hip and Knee Strength Assessments

Kollock

Oñate

Lunen

2010

Journal of Athletic Training

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Context: Insufficient lower extremity strength may be a risk factor for lower extremity injuries such as noncontact anterior cruciate ligament tears. Therefore, clinicians need reliable instruments to assess strength deficiencies.Objective: To assess the intrarater, interrater, intrasession, and intersession reliability of a portable fixed dynamometer in measuring the strength of the hip and knee musculature.Design: Crossover study. Setting: Sports medicine research laboratory.Patients or Other Participants: Three raters (A, B, C) participated in this 2-phase study. Raters A and B tested 11 healthy college graduate students (2 men, 9 women) in phase 1. Raters A and C tested 26 healthy college undergraduate students (7 men, 19 women) in phase 2.Main Outcome Measure(s): The dependent variables for the study were hip adductor, hip abductor, hip flexor, hip extensor, hip internal rotator, hip external rotator, knee flexor, and knee extensor peak force.Results: The phase 1 intrasession intraclass correlation coefficients for sessions 1, 2, and 3 ranged from 0.88 to 0. Conclusions: The portable fixed dynamometer showed good to high intrasession and intersession reliability values for hip and knee strength. Intrarater and interrater reliability were fair to high, except for hip internal rotation, which showed poor reliability.

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Development of a French Isometric Strength Normative Database for Adults Using Quantitative Muscle Testing

Cited by 99 publications

References 23 publications

Natural history of LGMD2A for delineating outcome measures in clinical trials

Natural history of LGMD2A for delineating outcome measures in clinical trials

Normative reference values for strength and flexibility of 1,000 children and adults

The Reliability of Portable Fixed Dynamometry During Hip and Knee Strength Assessments

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