2010
DOI: 10.1590/s1984-82502010000200003 View full text |Buy / Rent full text
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Abstract: A dissolution test for tablets containing 100 mg of lamotrigine was developed and validated. The dissolution test was applied to compare the dissolution profile of Neural ® with the reference product Lamictal ® . The analysis procedure was carried out using a simple ultraviolet method at 267 nm. After the determination of solubility and sink conditions, the parameters selected were paddles at 50 rpm, 900 mL of 0.01 M hydrochloric acid, and 30 minutes duration (single point). This method was validated for speci… Show more

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