Development of a catheter functionalized by a polydopamine peptide coating with antimicrobial and antibiofilm properties

Lim, Kaiyang; Chua, Ray Rong Yuan; Ho, Bow; Tambyah, Paul Anantharajah; Hadinoto, Kunn; Leong, Susanna Su Jan

doi:10.1016/j.actbio.2014.12.015

Cited by 177 publications

(134 citation statements)

References 58 publications

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“…According to the study, it was the first “proof-of-concept” study that has reported the efficacy of immobilized AMPs on a silicone catheter by sulfhydryl coupling. In another study conducted in 2015, an AMP, CWR11, was tethered to the surface of a polydimethylsiloxane (PDMS) film with the help of polydopamine (DOPA) [123]. The DOPA coating undergoes oxidative crosslinking, along with chemical bond formation with any surface silanol groups to provide robust coatings that are highly crosslinked.…”

Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

A review of the recent advances in antimicrobial coatings for urinary catheters

2017

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More than 75% of hospital-acquired or nosocomial urinary tract infections are initiated by urinary catheters, which are used during the treatment of 15–25% of hospitalized patients. Among other purposes, urinary catheters are primarily used for draining urine after surgeries and for urinary incontinence. During catheter-associated urinary tract infections, bacteria travel up to the bladder and cause infection. A major cause of catheter-associated urinary tract infection is attributed to the use of non-ideal materials in the fabrication of urinary catheters. Such materials allow for the colonization of microorganisms, leading to bacteriuria and infection, depending on the severity of symptoms. The ideal urinary catheter is made out of materials that are biocompatible, antimicrobial, and antifouling. Although an abundance of research has been conducted over the last forty-five years on the subject, the ideal biomaterial, especially for long-term catheterization of more than a month, has yet to be developed. The aim of this review is to highlight the recent advances (over the past 10 years) in developing antimicrobial materials for urinary catheters and to outline future requirements and prospects that guide catheter materials selection and design.

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Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

A review of the recent advances in antimicrobial coatings for urinary catheters

2017

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“…The mussel adhesive-inspired polydopamine (PD) appears to be an ideal biomaterial coating since it fulfils all these criteria. It exhibits low cytotoxicity [2], antibacterial properties [3,4], promotes cell growth [5][6][7][8], resists corrosion [9], can aid antibiotic release [10,11], is simple to produce with control over film thickness [12] and can be attached to a variety of surfaces including silanes [13], metals [9,14], polymers [7,[15][16][17] dentine [18] and even hair [19].…”

Section: Introductionmentioning

confidence: 99%

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

2017

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Polydopamine has been found to be a biocompatible polymer capable of supporting cell growth and attachment, and to have antibacterial and antifouling properties. Together with its ease of manufacture and application, it ought to make an ideal biomaterial and function well as a coating for implants. In this paper, atomic force microscope was used to measure the adhesive forces between polymer-, protein-or polydopamine-coated surfaces and a silicon nitride or polydopamine-functionalised probes. Surfaces were further characterised by contact angle goniometry, and solutions by circular dichroism. Polydopamine was further characterised with infrared spectroscopy and Raman spectroscopy. It was found that polydopamine functionalisation of the atomic force microscope probe significantly reduced adhesion to all tested surfaces. For example, adhesion to mica fell from 0.27 ± 0.7 to 0.05 ± 0.01 nN nm -1 . The results suggest that polydopamine coatings are suitable to be used for a variety of biomedical applications.

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“…Commonly used approaches include simple adsorption onto surfaces such as multi-walled carbon nanotube sheets [317] or titanium sheets, [318] covalent attachment onto a variety of materials via EDC/NHS coupling [319] or silanization, [318] click chemistry to attach to fluorous thin films and fluorosilicone, [320] and pre-deposition of an adherent film such as polydopamine to facilitate AMP attachment. [321] A recent comparison of immobilization of AMPs on titanium using silanization with 3-aminopropyltriethoxysilane (APTES) or polymer brush-based coatings prepared by surfaceinitiated ATRP with two different silanes concluded the latter methods led to a greater reduction in bacterial attachment though this was most likely due to a higher yield of immobilized peptide attainable with the approach. [322] The importance of ensuring the correct orientation of peptides has also been demonstrated in a study in which the antimicrobial activity of melamine, immobilized on maleimide-functionalized glass via an engineered cysteine, was found to vary greatly based on the position of the introduced cysteine.…”

Section: Progress Reportmentioning

confidence: 97%

Adding Functions to Biomaterial Surfaces through Protein Incorporation

et al. 2016

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The concept of biomaterials has evolved from one of inert mechanical supports with a long-term, biologically inactive role in the body into complex matrices that exhibit selective cell binding, promote proliferation and matrix production, and may ultimately become replaced by newly generated tissues in vivo. Functionalization of material surfaces with biomolecules is critical to their ability to evade immunorecognition, interact productively with surrounding tissues and extracellular matrix, and avoid bacterial colonization. Antibody molecules and their derived fragments are commonly immobilized on materials to mediate coating with specific cell types in fields such as stent endothelialization and drug delivery. The incorporation of growth factors into biomaterials has found application in promoting and accelerating bone formation in osteogenerative and related applications. Peptides and extracellular matrix proteins can impart biomolecule- and cell-specificities to materials while antimicrobial peptides have found roles in preventing biofilm formation on devices and implants. In this progress report, we detail developments in the use of diverse proteins and peptides to modify the surfaces of hard biomaterials in vivo and in vitro. Chemical approaches to immobilizing active biomolecules are presented, as well as platform technologies for isolation or generation of natural or synthetic molecules suitable for biomaterial functionalization.

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Development of a catheter functionalized by a polydopamine peptide coating with antimicrobial and antibiofilm properties

Cited by 177 publications

References 58 publications

A review of the recent advances in antimicrobial coatings for urinary catheters

A review of the recent advances in antimicrobial coatings for urinary catheters

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

Adding Functions to Biomaterial Surfaces through Protein Incorporation

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