Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles

Omwoyo, Wesley Nyaigoti; Melariri, Paula; Gathirwa, Jeremiah; Oloo, Florence; Mahanga, Geoffrey M.; Kalombo, Lonji; Ogutu, Bernhards; Swai, Hulda

doi:10.1016/j.nano.2015.11.017

Cited by 60 publications

(40 citation statements)

References 35 publications

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“…From the results obtained, the formulation with an internal to the external ratio of 1:1 comparatively gave the largest particle sizes with a non-uniform particle distribution (PDI=0.304). The PDI values are expected to be generally low (0.001-0.290) for a homogeneous system [19]. The higher values of PDI are an indication of a very wide distribution of particle sizes, and this is also evident from the nature of the graph obtained from the PCS analysis ( Fig.…”

Section: Resultsmentioning

confidence: 92%

“…High values of zeta potential correlate with a lesser tendency to aggregate or flocculate and are indicative colloidal stability of the nanoformulation [21]. Studies have reported that electrostatically stable nanoformulations should have a minimum zeta potential of ±30 [10,19]. It is evident from the results given in Table 2 that all the prepared formulations showed good stability as seen from the high values of zeta potential.…”

Section: Zeta Potentialmentioning

confidence: 86%

“…of poorly water-soluble drugs [16][17][18]. This encapsulation is what leads to the formation of the solid lipid nanoparticles (SLNs) which are submicron colloidal drug carriers composed of lipids or waxes dispersed in an aqueous surfactant solution [17,19,20].…”

Section: Omwoyo and Molotomentioning

confidence: 99%

“…The nanoparticle drug carriers were prepared by the method described by Omwoyo et al, [17,19] with slight modifications. Nanoparticle drug carriers for IBU were prepared using a modified emulsification solvent evaporation technique.…”

Section: Preparation Of Ibu Loaded Slnsmentioning

confidence: 99%

“…4) which indicates the existence of an amorphous state of the nanoparticles as compared to the crystalline nature of the drug. This is attributed to the incorporation of IBU into the lipid matrix and successful encapsulation of the drug inside the excipients [18,19,25].…”

Section: Xrdmentioning

confidence: 99%

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Encapsulation of Ibuprofen Into Solid Lipid Nanoparticles for Controlled and Sustained Release Using Emulsification Solvent Evaporation Technique

Omwoyo

Moloto

2019

Asian J Pharm Clin Res

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Objective: The objective of the study was to encapsulate ibuprofen (IBU) into solid lipid nanoparticles (SLNs) for enhanced dissolution and achieving a sustained and controlled release of the drug from the nanocarrier. Methods: IBU loaded nanoparticles were prepared by emulsification solvent evaporation technique and characterized by Fourier Transform Infrared spectroscopy, Thermogravimetric Analysis, X-ray diffraction (XRD), and transmission electron microscopy. Release kinetics on the drug-loaded nanoparticles was carried out in phosphate buffer pH 6.8 using pharma test dissolution apparatus adopting shaking basket method at 37°C. Results: The optimized IBU-loaded SLNs had a particle size of 76.40 nm, polydispersity index of 0.275, and zeta potential of −41.3 mV. The encapsulation efficiency (EE) and DL were 99.73% and 2.31%, respectively. The Fourier transform infrared spectroscopy (FTIR) spectra confirmed successful encapsulation of the drug inside the nanocarrier as only peaks responsible for the emulsifier and the binder could be identified. This corroborated well with XRD spectra which showed a completely amorphous state of the drug-loaded nanoparticles as compared to the crystalline nature of the pure drug. The IBU-SLNs showed a release profile of up to 8 h which is a great improvement from other reported works. The drug release pattern of IBU-SLNs was best fitted with Higuchi square root model and followed the Higuchi drug release kinetics. Korsmeyer-Peppas model confirmed a non-Fickian diffusion model for the release of the drug from the matrix system. Conclusion: IBU-loaded SLNs were successfully prepared which had a sustained and controlled release. It was observed that the release of the drug from the matrix was diffusion controlled and time dependent.

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Section: Resultsmentioning

confidence: 92%

Section: Zeta Potentialmentioning

confidence: 86%