Development and validation of the WASP classification system for optical diagnosis of adenomas, hyperplastic polyps and sessile serrated adenomas/polyps

IJspeert, Joep E. G.; Bastiaansen, Barbara A.; Leerdam, Monique E. van; Meijer, Gerrit A.; Eeden, Susanne van; Sanduleanu, Silvia; Schoon, Erik J.; Bisseling, Tanya M.; Spaander, Manon; Lelyveld, Niels van; Bargeman, Marloes; Wang, Junfeng; Dekker, Evelien; Polyposis, Dutch Workgroup serrAted polypS

doi:10.1136/gutjnl-2014-308411

Cited by 224 publications

(204 citation statements)

References 38 publications

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“…We caution, however, that endoscopic criteria for differentiation of SSA/P from HP are emerging, and endoscopists could still be reasonably advised to resect and submit to pathology any lesion with endoscopic features found in the WASP classification that predict SSA/P histology, even when the lesion is diminutive and located in the rectosigmoid. In our experience, this consideration mainly applies to serrated lesions with large open pits because other WASP criteria such as indiscrete edges, a cloud-like appearance, and an irregular surface 3 , are seldom observed in diminutive lesions that appear otherwise to be serrated class (NICE type I lesions).…”

Section: Discussionmentioning

confidence: 99%

“…For example, the NICE classification differentiates serrated lesions from conventional adenomas, but makes no attempt to differentiate SSA/P from HP endoscopically 2 . Recently, the WASP criteria have been validated for endoscopic differentiation of SSA/P from HP, but the success of these criteria in distinguishing HP from SSA/P among diminutive serrated lesions is uncertain 3 . In general, the chance that a given serrated lesion is an SSA/P rather than an HP increases with lesion size and proximal colon location 1,4,5 The issue of defining the prevalence of SSA/P within diminutive rectosigmoid polyps is assuming increasing importance.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps

Ponugoti

Odze

et al. 2017

Gastrointestinal Endoscopy

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps

Ponugoti

Odze

et al. 2017

Gastrointestinal Endoscopy

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“…Recently, the Workgroup Serrated Polyps and Polyposis (WASP) classification was developed and validated to allow endoscopic differentiation between adenomas, HPs, and SSA/Ps < 10 mm in a stepwise approach (Fig. 5) [53]. First, colonic polyps are assessed for the presence of adenoma-like features using the NICE criteria.…”

Section: Colonmentioning

confidence: 99%

“…Most colorectal polyps/superficial lesions are histologically classified into adenomas and serrated polyps (hyperplastic polyps [HPs], sessile serrated adenomas/polyps [SSA/Ps], and traditional serrated adenomas) [53]. …”

Section: Colonmentioning

confidence: 99%

Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy

Barbeiro

Libânio

Castro

et al. 2018

GE Port J Gastroenterol

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Narrow-band imaging is an advanced imaging system that applies optic digital methods to enhance endoscopic images and improves visualization of the mucosal surface architecture and microvascular pattern. Narrow-band imaging use has been suggested to be an important adjunctive tool to white-light endoscopy to improve the detection of lesions in the digestive tract. Importantly, it also allows the distinction between benign and malignant lesions, targeting biopsies, prediction of the risk of invasive cancer, delimitation of resection margins, and identification of residual neoplasia in a scar. Thus, in expert hands it is a useful tool that enables the physician to decide on the best treatment (endoscopic or surgical) and management. Current evidence suggests that it should be used routinely for patients at increased risk for digestive neoplastic lesions and could become the standard of care in the near future, at least in referral centers. However, adequate training programs to promote the implementation of narrow-band imaging in daily clinical practice are needed. In this review, we summarize the current scientific evidence on the clinical usefulness of narrow-band imaging in the diagnosis and characterization of digestive tract lesions/cancers and describe the available classification systems.

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“…Morfológiailag hasonló a HP-hez, viszont igen magas malignus potenciállal bír, ami miatt elkülönítésük igen lényeges már a korai stádi-umban [27]. Utóbb megbízható eredményeket értek el a differenciáldiagnosztikában a Workgroup serrAted polypS and Polyposis (WASP-) klasszifikációval [28]. Morfológiailag a SSA/P általában nagyobb (>10 mm), a normálnyálkahártyánál halványabb színű és attól bizonytalan széllel elkülönülő elváltozás, mely főként a jobb colonfélre lokalizálódik.…”

Section: Szesszilis Fogazott Adenoma/polip (Ssa/p)unclassified

Heterogén vastagbéldaganat: a fogazott útvonalon kialakuló, sporadikus laesiók jelentősége a klinikai gyakorlatban

et al. 2018

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A colorectalis daganatra ma már igen heterogén betegségként tekintünk, mely heterogenitást a kialakulásában szerepet játszó genetikai faktorok, molekuláris eltérések, különböző jelátviteli útvonalak, valamint mikro-és makrokörnye-zeti tényezők okoznak. A korábban ismert ,,klasszikus" adenoma-carcinoma szekvencia mellett az elmúlt évtizedben egy másik, alternatív útvonal is felismerésre került. Ezt ,,fogazott" útvonalnak nevezzük, mely az elváltozások kb. egyharmadáért felelős. Ezek a laesiók a molekuláris tulajdonságaikon felül makroszkópos és mikroszkópos képükben és progressziós hajlamukban, illetve prognózisukban is eltérnek a klasszikus útvonal daganataitól. Az alábbi összefog-laló közlemény ezen eltérések molekuláris tulajdonságait, makroszkópos és szövettani jellegzetességeit, illetve klinikai jelentőségét szemlélteti. Orv Hetil. 2018; 159(6): 206-214. Kulcsszavak: vastagbéldaganat, fogazott útvonal, polip, prognózis Colorectal cancer heterogeneity: the clinical impact of sporadic lesions arising via the serrated pathwayToday, colorectal cancer is regarded as a heterogeneous disease. Its heterogeneity is caused by genetic alterations, molecular aberrations, different developing pathways as well as by micro-and macroenviromental agents. In the last decade, beside the classic genetic model for colorectal tumuorgenesis that follows the adenoma-carcinoma sequence, an alternative pathway has been identified. This pathway is called the serrated pathway and it is responsible for approximately one third of all colorectal lesions. Beyond their dissimilar molecular characteristics, these tumours also show different macroscopic and histologic appearance. Moreover, their malignant potency and progressive ability distinguish them from tumours of the classic genetic model. The aim of this review is to summarize the molecular and pathologic features of serrated lesions and the serrated pathway to colorectal cancer and to highlight their clinical impact. Keywords

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Development and validation of the WASP classification system for optical diagnosis of adenomas, hyperplastic polyps and sessile serrated adenomas/polyps

Cited by 224 publications

References 38 publications

Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps

Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps

Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy

Heterogén vastagbéldaganat: a fogazott útvonalon kialakuló, sporadikus laesiók jelentősége a klinikai gyakorlatban

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