2009
DOI: 10.1590/s1984-82502009000100010
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Abstract: A simple, rapid, accurate and sensitive method was developed for quantitative analysis of dexamethasone acetate in microemulsions using high performance liquid chromatography (HPLC) with UV detection. The chromatography parameters were stainless steel Lichrospher 100 RP-18 column (250 mm x 4 mm i.d., 5 µm particle size), at 30 ± 2 ºC. The isocratic mobile phase was methanol:water (65:35; v/v) at a flow rate of at 1.0 mL.min -1. The determinations were performed using UV-Vis detector set at 239 nm. Samples were… Show more

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Cited by 18 publications
(15 citation statements)
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References 14 publications
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“…Dexamethasone (8S,9R,10S,11S,13S,14S,1 6R,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-, 7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a] phenanthren-3-one [ Figure 1] a corticosteroid, is used to relieve bacterial ocular infections that require corticosteroid [1]. Many authors have reported a lot of different analytical methods for both drugs individually utilizing different techniques like HPLC [2][3][4][5][6][7][8][9], spectrophotometry and spectrofluorometric [10][11][12][13], titrimetric [14] methods for ciprofloxacin while for dexamethasone different methods involving HPLC, GC and TLC are reported [15][16][17][18][19][20][21].…”
Section: Ciprofloxacinmentioning
confidence: 99%
“…Dexamethasone (8S,9R,10S,11S,13S,14S,1 6R,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-, 7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a] phenanthren-3-one [ Figure 1] a corticosteroid, is used to relieve bacterial ocular infections that require corticosteroid [1]. Many authors have reported a lot of different analytical methods for both drugs individually utilizing different techniques like HPLC [2][3][4][5][6][7][8][9], spectrophotometry and spectrofluorometric [10][11][12][13], titrimetric [14] methods for ciprofloxacin while for dexamethasone different methods involving HPLC, GC and TLC are reported [15][16][17][18][19][20][21].…”
Section: Ciprofloxacinmentioning
confidence: 99%
“…to evaluate the specificity of the analytical method, the blank and drug loaded pharmaceutical formulation has been injected into the chromatographic system. These parameters were determined by comparing the chromatograms of the voriconazole standard, drug loaded in situ gel and blank in situ gel (15).…”
Section: Specificity/selectivitymentioning
confidence: 99%
“…Consequently, linearity, precision, specificity, accuracy, sensitivity, and quantification limit must be demonstrated in the test for analysis adequacy [16,17]. The objective of present work is to quantification of andrographolide isolated from A. paniculata Ness found in a traditional market in Yogyakarta using validated HPLC to obtain high-level content of andrographolide.…”
Section: Introductionmentioning
confidence: 99%