2017
DOI: 10.5155/eurjchem.8.4.371-377.1646
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Abstract: In this study, we developed and validated different spectrophotometric and chromatographic methods for determination of clotrimazole (CLO) and hydrocortisone (HDC) in their combined dosage form. The developed spectrophotometric methods were first derivative spectrophotometry ( 1 D) by measuring the peak amplitude at 247.4 and 236.2 nm for CLO and HDC, respectively, second derivative of ratio spectra ( 2 DD) at 225.4 nm for CLO and 269 nm for HDC, dual wavelength spectrophotometry (DW) by measuring absorbance d… Show more

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Cited by 3 publications
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“…This method can be applied to determine the ternary mixture of the investigated compounds whose spectra show a severe overlap [22,23]. It is based on the principles of both the ratio difference method [34][35][36] and the dual wavelength method [37][38][39][40]. The proposed method can determine a ternary mixture, such that every compound can be selectively determined after total elimination of the impediment caused by the other two compounds.…”
Section: Dual-wavelength-in-ratio Spectra Methodsmentioning
confidence: 99%
“…This method can be applied to determine the ternary mixture of the investigated compounds whose spectra show a severe overlap [22,23]. It is based on the principles of both the ratio difference method [34][35][36] and the dual wavelength method [37][38][39][40]. The proposed method can determine a ternary mixture, such that every compound can be selectively determined after total elimination of the impediment caused by the other two compounds.…”
Section: Dual-wavelength-in-ratio Spectra Methodsmentioning
confidence: 99%