Development and validation of an integrated microfluidic device with an in-line Surface Enhanced Raman Spectroscopy (SERS) detection of glyphosate in drinking water

Emonds-Alt, Gauthier; Malherbe, Cédric; Kasemiire, Alice; Avohou, Hermane T.; Hubert, Philippe; Ziémons, Eric; Monbaliu, Jean‐Christophe M.; Eppe, Gauthier

doi:10.1016/j.talanta.2022.123640

Cited by 18 publications

(8 citation statements)

References 47 publications

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“…Pesticide residues in foods are a serious problem for public health and environment, and it is important to detect them label-free. ,− The high signal enhancement, good homogeneity, and good sample-to-sample repeatability of the green SERS paper are encouraging for its adoption as a sensor platform. Therefore, the platform is used to detect and categorize common pesticides regularly found as pollutants in drinking water.…”

Section: Resultsmentioning

confidence: 99%

Machine Learning-Assisted Pesticide Detection on a Flexible Surface-Enhanced Raman Scattering Substrate Prepared by Silver Nanoparticles

Şahin

Çelik

Çamdal

et al. 2022

ACS Appl. Nano Mater.

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Access to clean water is a pressing challenge affecting millions of lives and the aquatic body of the Earth. Sensitive detection of pollutants such as pesticides is particularly important to address this challenge. This study reports eco-friendly preparation of the surface-enhanced Raman scattering (SERS) substrate for machine learning-assisted detection of pesticides in water. The proposed SERS platform was prepared on a copy paper by reducing a silver salt using the extract of a natural plant, Cedrus libani. The fabricated SERS platform was characterized in detail using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The high-density formation of silver nanoparticles with an average diameter of 41 nm on the surface of the paper enabled detection of analytes with a nanomolar level sensitivity. This SERS capability was used to collect Raman signals of four different pesticides in water: myclobutanil, phosmet, thiram, and abamectin. Raman spectra of the pesticides are highly complex, challenging accurate determination of the pesticide type. To overcome this challenge and distinguish pesticides, machine learning (ML) approach was used. The ML-mediated detection of harmful pesticides on a versatile, green, and inexpensive SERS platform appears to be promising for environmental applications.

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Section: Resultsmentioning

confidence: 99%

Machine Learning-Assisted Pesticide Detection on a Flexible Surface-Enhanced Raman Scattering Substrate Prepared by Silver Nanoparticles

Şahin

Çelik

Çamdal

et al. 2022

ACS Appl. Nano Mater.

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“…Moreover, the site-specific photodeposition will facilitate the manufacturing of an in-flow WGM optical microbubble resonator for GLP sensing. Thus far, studies on microfluidic sensors of GLP have demonstrated devising in-line (surface-enhanced Raman spectroscopy)-based sensor, 47 electrophoresis-coupled disposable microchips with laser-induced fluorescence detection, 69 an in-chamber copper-based water-gated organic field-effect transistor (WG-OFET), 70 a (μ3D-paper-assisted) device functionalized with quantum dot-embedded poly( N -isopropylacrylamide) and N , N ′-methylenebis(acrylamide) MIPs, 24 and a methyl methacrylate MIP-based electrochemical lab-on-a-chip. 26 Our procedure for on-surface photopolymerizing acrylamide encapsulating GLP enables simple and economical devising future systems for GLP detection and degradation.…”

Section: Future Prospectivementioning

confidence: 99%

“…Thus far, in-depth micro-Raman spectroscopy has been used for sub-micro-structurization and vapor–liquid phase transition in a high-pressure microcapillary cell, as well as to study biological molecules and to identify primary human bronchial epithelial cells . Regarding GLP sensing, the GLP content was determined with surface-enhanced Raman scattering (SERS) spectroscopy using gold nanoparticles and silver composites . Our current research presents a successful application of micro-Raman spectroscopy to GLP-applied polymer science.…”

Section: Introductionmentioning

confidence: 99%

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In-Capillary Photodeposition of Glyphosate-Containing Polyacrylamide Nanometer-Thick Films

Mazuryk

Klepacka

Piechowska

et al. 2022

ACS Appl. Polym. Mater.

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The present research reports on in-water, site-specific photodeposition of glyphosate (GLP)-containing polyacrylamide (PAA-GLP) nanometer-thick films (nanofilms) on an inner surface of fused silica (fused quartz) microcapillaries presilanized with trimethoxy(octen-7yl)silane (TMOS). TMOS was chosen because of the vinyl group presence in its structure, enabling its participation in the (UV light)activated free-radical polymerization (UV-FRP) after its immobilization on a fused silica surface. The photodeposition was conducted in an aqueous (H 2 O/ACN; 3:1, v/v) solution, using UV-FRP (λ = 365 nm) of the acrylamide (AA) functional monomer, the N,N′-methylenebis(acrylamide) (BAA) cross-linking monomer, GLP, and the azobisisobutyronitrile (AIBN) UV-FRP initiator. Acetonitrile (ACN) was used as the porogen and the solvent to dissolve monomers and GLP. Because of the micrometric diameters of microcapillaries, the silanization and photodeposition procedures were first optimized on fused silica slides. The introduction of TMOS, as well as the formation of PAA and PAA-GLP nanofilms, was determined using atomic force microscopy (AFM), scanning electron microscopy with energy-dispersive X-ray (SEM−EDX) spectroscopy, and confocal micro-Raman spectroscopy. Particularly, AFM and SEM−EDX measurements determined nanofilms' thickness and GLP content, respectively, whereas in-depth confocal (micro-Raman spectroscopy)-assisted imaging of PAA-and PAA-GLP-coated microcapillary inner surfaces confirmed the successful photodeposition. Moreover, we examined the GLP impact on polymer gelation by monitoring hydration in a hydrogel and a dried powder PAA-GLP. Our study demonstrated the usefulness of the in-capillary micro-Raman spectroscopy imaging and in-depth profiling of GLP-encapsulated PAA nanofilms. In the future, our simple and inexpensive procedure will enable the fabrication of polymer-based microfluidic chemosensors or adsorptive-separating devices for GLP detection, determination, and degradation.

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“…Although most of these strategies could monitor xanthine with robust performance, they had many disadvantages, such as needing relatively sophisticated instruments, complex chemical modification, and professional operators, thus limiting their practical application. The surface-enhanced Raman spectroscopy (SERS) technique has shown many advantages, including high sensitivity, specific signal attainability, rapidity, small sample volume requirement, and non-destructivity, and it has been extensively used in food safety, [17][18][19] environmental protection, 20,21 bioanalysis, and disease diagnosis. 22,23 Although excellent performance could be achieved with SERS technology, it still had difficulty in obtaining reproducible signals for SERS substrates, which made it difficult to achieve quantitative detection.…”

Section: Introductionmentioning

confidence: 99%

A ratiometric SERS sensor with one signal probe for ultrasensitive and quantitative monitoring of serum xanthine

Wu,

Yi,

Zang

et al. 2023

Analyst

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Development and validation of an integrated microfluidic device with an in-line Surface Enhanced Raman Spectroscopy (SERS) detection of glyphosate in drinking water

Cited by 18 publications

References 47 publications

Machine Learning-Assisted Pesticide Detection on a Flexible Surface-Enhanced Raman Scattering Substrate Prepared by Silver Nanoparticles

Machine Learning-Assisted Pesticide Detection on a Flexible Surface-Enhanced Raman Scattering Substrate Prepared by Silver Nanoparticles

In-Capillary Photodeposition of Glyphosate-Containing Polyacrylamide Nanometer-Thick Films

A ratiometric SERS sensor with one signal probe for ultrasensitive and quantitative monitoring of serum xanthine

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