2017
DOI: 10.1590/s2175-97902017000216033
|View full text |Cite
|
Sign up to set email alerts
|

Development and validation of an analytical method using High Performance Liquid Chromatography (HPLC) to determine ethyl butylacetylaminopropionate in topical repellent formulations

Abstract: Diseases caused by insects are frequent in poor countries, leading to epidemic scenarios in urban areas; e.g., Dengue, Zika and Chikungunya. For this reason, the development of a safe and efficient topical formulation is essential. Ethyl butylacetylaminopropionate (EB) is a mosquito repellent developed by Merck, which is used in products for adults, children and especially babies, due to its low allergenic potential. The aim of this work was to validate an analytical methodology to quantify EB in a new poloxam… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
6
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(6 citation statements)
references
References 17 publications
0
6
0
Order By: Relevance
“…The statistical analysis was evaluated by ANOVA (Table 2) and data no presented significant linearity deviation at a 5% level of variance, exhibiting F calculated (2.80) lower than the F critical (2.96) demonstrating that the method used is linear in the range of 0.5 to 100 µg/mL. 24 precision. These results indicate that the analytical method presented has good precision.…”
Section: Validation Of Hplc Methodsmentioning
confidence: 99%
“…The statistical analysis was evaluated by ANOVA (Table 2) and data no presented significant linearity deviation at a 5% level of variance, exhibiting F calculated (2.80) lower than the F critical (2.96) demonstrating that the method used is linear in the range of 0.5 to 100 µg/mL. 24 precision. These results indicate that the analytical method presented has good precision.…”
Section: Validation Of Hplc Methodsmentioning
confidence: 99%
“…The accuracy of the method met the accuracy requirements for method validation with a range recovery percentage of 98 % to 102 % (Pinto et al, 2017). The precision of the method was met with the precision requirements for method validation with a relative standard deviation of less than 2% (Assali et al, 2020).…”
Section: Vibration Spectrum Determination Resultsmentioning
confidence: 82%
“…σ value is a good measure of how accurately the model predicted the response. The results obtained for the intra-assay precision (repeatability) and for inter-assay precision were great since, RSD values were lower than 5% (Table 2) [18]. The recovery degree (Table 3) ranged between 96-132%.…”
Section: Resultsmentioning
confidence: 92%
“…where SD is the standard deviation of the y intercept of three curves and x is the mean of the peak area [18].…”
Section: Lod = 33*σ/smentioning
confidence: 99%