“…30 Besides, another three models were also established for solid nodules based on a Chinese population (AUC=0.85~0.87). [31][32][33] Compared to these four models, the current solid-nodule models shared some similar risk factors, such as age, sex, history of malignancy, morphology, and serum CEA, but some novel markers like V25, RV/TLC, serum lymphocyte, CYFRA21-1, and NSE were also identified. As for model performance, these four were a little better than our models (AUC=0.82), which can be associated with some valuable predictors they enrolled, such as enhancement, VDT, as well as maximum uptake value of nodules.…”