Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing

Rezvanian, Masoud; Amin, Mohd Cairul Iqbal Mohd; Ng, Shiow Fern

doi:10.1016/j.carbpol.2015.10.091

Cited by 185 publications

(138 citation statements)

References 34 publications

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“…These advanced dressings aim to function beyond covering the wound from the external environment. In addition, polysaccharides have demonstrated an ability to act as a drug delivery scaffold, enabling potential delivery of relevant wound healing therapeutics such as silver …”

Section: Introductionmentioning

confidence: 99%

Fabrication, characterization, and in vitro evaluation of silver‐containing arabinoxylan foams as antimicrobial wound dressing

Aduba

Selders

et al. 2016

J Biomedical Materials Res

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Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam’s rheological, morphological, porous and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 hours. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity, necessary to be a candidate material in wound dressing development.

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Section: Introductionmentioning

confidence: 99%

Fabrication, characterization, and in vitro evaluation of silver‐containing arabinoxylan foams as antimicrobial wound dressing

Aduba

Selders

et al. 2016

J Biomedical Materials Res

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“…Along with hydrophobic polymers, hydrophilic films insoluble in wound exudate are used, for example, copolymers of a acrylate with vinyl acetate and other monomers, or films of polyvinyl alcohol and polyvinylpyrrolidone. [12,13] Isolation films of the second group, formed directly on the wound surface, are represented in the form of aerosol compositions, when applied to the wound for 1-2 min, due to evaporation of the solvent, a dressing is created in the form of a film.…”

Section: Resultsmentioning

confidence: 99%

“…The standard technology is pouring on a surface. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Preparing gelling solution, the first stage of which is the dissolution stage precedes pouring. Depending on the properties of the ingredients, it is possible to dissolve hydrophilic polymers in water separately, heating it, and to dissolve active and auxiliary substances in matching solvents with further combining the formed solutions; or to dissolve auxiliary substances insolvent or a mixture of solvents, and then adding active pharmaceutical ingredients to this solution.…”

Section: Technological Processmentioning

confidence: 99%

“…A kind of a dosage form for treating patients with skin defects, which are the results of purulent infection of soft tissues, are wound dressings. [2,7,12,13,36] The correct choice of a wound dressing with a certain mechanism of action can significantly improve the effectiveness of the purulent wounds treatment. Nowadays, more than 300 types of wound dressings are used in clinical practice.…”

Section: Application Of Films In Medicinementioning

confidence: 99%

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Хохленкова

2017

AJP

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Introduction: Nowadays, biopolymers and biomaterials are an actively developing field, interesting both for specialists from various fields of science and for society at large. The range of polymers of both natural and synthetic origin is constantly expanding, but only a few of them are used in pharmaceutical production and medical practice. Due to the composition of polymers and active pharmaceutical ingredient, films are a promising form for applying in dentistry, ophthalmology, surgery, and other fields of medicine. Materials and Methods: In the work marketing and economic research methods are used to ground social and medical practicability of developing new dental products for local treatment. Results and Discussions: Based on the data of modern scientific literature, the requirements for medicinal films are outlined, their classification is given. Approaches to the choice of active and auxiliary substances in the process of developing new film formulations are described. The prospects of using films in surgery, dentistry, ophthalmology, and dermatology are shown. Conclusions: Based on the review, polymer films have been classified, and the requirements for the given dosage form have been defined. Approaches to selecting active and auxiliary ingredients have been considered. The main aspects of the technological process for the preparation of films are described. The ways of rational application of films in medical practice have been highlighted.

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“…Controlling drug release provides sustained delivery over specific period of time and reduces the amount of drug necessary to cause the same effect. In order to control the release profile of topical drugs, different systems of drug encapsulation have been employed over the last few decades (Huang and Brazel, 2001) such as hydrogels (Cheng et al, 2014), films (Rezvanian et al, 2016), hydrocolloids (Jin et al, 2015), liposomes (Abdel-Azeem and and non-woven mats (Supaphol and Suwantong, 2012). Among those systems of encapsulation, electrospinning of the carbohydrate polymers has been established due to its simple procedure and its potentials (Ghosh, 2006).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Nicotinamide into Cellulose Based Electrospun Fibers

Nada¹,

Hassabo²,

Mohamed³

et al. 2016

J App Pharm Sci

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Systematic application of topical drugs has been widely prescribed as an effective treatment for skin disorders. However, the widespread use of such topical drugs is also associated with emergence of resistant strains of microorganisms resulting in patients resist for one or more antibiotics. Nicotinamide, a water-soluble amide of nicotinic acid and a common topical drug, is approved as anti-acne drug with anti-inflammatory potentials. Encapsulation of nicotinamide into electrospun water-soluble matrix that chemically crosslinked is the approach to control its release. In this research, biocompatible nano-fibrous mat was developed with hydroxyethyl cellulose (HEC) blended with poly(vinyl alcohol) (PVA) by electro-spinning technique. The concentration of HEC (5% w/v) with PVA (10% w/v) was optimized, blended in different ratios (20-50% HEC concentration) and electro-spun to get smooth nano-fibers. Nicotinamide was successfully encapsulated in the electro-spun fibers. Nicotinamide release was controlled via chemical cross-linking of the produced mat. Selected parameters of spinning solutions (viscosity and conductivity) and process parameters (applied voltage and needle-to-collector distance) were studied. The microstructure, morphology of blended HEC/PVA, nicotinamide -loaded nano-fiber, cross-linked HEC/PVA nano-fibrous scaffolds were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR). SEM images showed that the mean diameters of blend nanofibers were ranged from 80 to 60 nm. The release profile of the nicotinamide was demonstrated. Release profile of the uncrosslinked and crosslinked mats were demonstred. Immortalized human skin fibroblasts cells were used to examine the biocompatibility of the produced HEC/PVA/ nicotinamide electrospun mats.

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Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing

Cited by 185 publications

References 34 publications

Fabrication, characterization, and in vitro evaluation of silver‐containing arabinoxylan foams as antimicrobial wound dressing

Fabrication, characterization, and in vitro evaluation of silver‐containing arabinoxylan foams as antimicrobial wound dressing

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Encapsulation of Nicotinamide into Cellulose Based Electrospun Fibers

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