Development and optimization of Clotrimazole‒Rosehip oil nanoethosomal-gel for oral thrush and gingivitis

Sindi, Amal M.; Alharbi, Waleed S.; Alkhalidi, Hala M.; Alghaith, Adel F.; Hosny, Khaled M.

doi:10.1016/j.jddst.2021.102482

Cited by 11 publications

(7 citation statements)

References 49 publications

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“…Therefore, the types and concentrations of phospholipids should be carefully selected according to the main aim of the study. The most commonly used phospholipids in ethosomal formulations are phospholipon 90G (25)(26)(27)(28)(29), phospholipon 90H (30)(31)(32), and α-phosphatidylcholine (33)(34)(35). Phospholipids were reported in ethosomal formulations at concentration ranges between 0.5 and 5.0 percent (36).…”

Section: Phospholipidsmentioning

confidence: 99%

Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Abubakr

Ibrahem

salah

2023

ERU Research Journal

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Ethosomal system is a lipid vesicular nanocarrier that holds a high concentration of alcohols. This nanocarrier is optimized for the dermal and transdermal delivery of medicinal drugs with various physicochemical features. Since its release in 1996, ethosomes have been subjected to subsequent studies to modify the original formula via the addition of different components, leading to the development of novel ethosomal system types. These new carriers are prepared via a variety of methods and characterized through different parameters, including vesicular size, zeta potential, entrapment efficiency, and skin permeation. The ethosomes efficacy in dermal/transdermal administration is evaluated via clinical studies as well as a wide range of in vivo models.Ethosomal dispersions are frequently incorporated into topical preparations, including gels, patches, and lotions, due to their stability and convenience. This article provides a thorough overview of ethosomal systems from the standpoint of ethosomal types, beginning with classical ethosomes and progressing to binary ethosomes and transethosomes. In addition, this work provides a comprehensive overview of the components of the ethosomal system and their contribution to the final properties of ethosomes, besides highlighting the different methods of preparation and the common dosage forms used as ethosomes' vehicles.

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Section: Phospholipidsmentioning

confidence: 99%

Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Abubakr

Ibrahem

salah

2023

ERU Research Journal

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“…To determine the antifungal efficacy of the formulations, the study was carried out as previously described 14 with slight modifications.…”

Section: In Vivo Antifungal Studymentioning

confidence: 99%

“…According to extant literature, many workers have reported the use of novel drug delivery systems, including ufosomes 6 , microand nano-emulsions 7,8 , polymeric nanoparticles 9 , nanogel 10 , solid lipid nanoparticles 11 , phospholipid vesicles 12 , nanocapsules 13 , nanoethosomal gel 14 , nanomicelles 15 , proliposomes 16 , and lipospheres 17 to improve the biopharmaceutical dispositions of CLOT for enhanced patient compliance, and toxicity elimination. Lipid nanoemulsions (LNE) are transparent or translucent and stable submicron dispersions of immiscible liquids (oil and water) stabilized using surfactants with droplet size ranges of 20 -200 nm.…”

Section: Introductionmentioning

confidence: 99%

Lipid Nanoemulsion-Based Liquisolid Compact Tablets for Oral Delivery of Clotrimazole: Fabrication Strategies, Characterizations, Antimycotic and Toxicological Evaluations

Umeyor

Ezechukwu²,

Okafor³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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This work aims to fabricate liquisolid compact tablets incorporating clotrimazole (CLOT)loaded lipid nanoemulsions (LNE) for oral treatment of systemic fungal infections.Nanoemulsion was characterized for droplet size, rendered into free-flowing granules and compressed into liquisolid compact tablets, and evaluated using pharmacopoeial and nonpharmacopoeial methods. In-vitro and in vivo antifungal, stability and toxicological tests of the tablets were evaluated. . Liquisolid tablets were stable, non-toxic, had uniform weight (341.4 ± 1.2 -346.7 ± 0.8 mg), drug content uniformity (85.2 ± 0.1 -99.8 ± 0.2 %), and had excellent disintegration (2.96 ± 0.8 -5.88 ± 1.3 min), and controlled release property. In-vitro and in vivo antifungal evaluations revealed improved antimycotic activity of CLOT. The results highlight that CLOT-LNE liquisolid compact tablets is a promising carrier system with improved oral utility for the treatment of systemic fungal infections.

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“…According to the Biopharmaceutics Classification System (BCS), clotrimazole is a Class II drug with low water solubility (0.49 mg/L) and high lipophilicity, which means that it has poor oral bioavailability and limited antifungal activity. , Clotrimazole is readily absorbed, distributed, and excreted as an inactive metabolite through the liver and bile; therefore, it is primarily used in topical formulations such as sprays, powders, or creams. − Hydrogels containing clotrimazole–rosehip oil nanoliposomes (clotrimazole-RO-NE) are being used to improve the efficacy of thrush and gingivitis. On being used in oral formulations, clotrimazole is also effective in preventing thrush for immunocompromised patients. , In addition to its antifungal activity, clotrimazole is also an important drug in the treatment of sickle cell diseases such as malaria and certain cancers. − …”

Section: Introductionmentioning

confidence: 99%

“…On being used in oral formulations, clotrimazole is also effective in preventing thrush for immunocompromised patients. 8,9 In addition to its antifungal activity, clotrimazole is also an important drug in the treatment of sickle cell diseases such as malaria and certain cancers. 10−12 For the production of clotrimazole, crystallization is an important step in its separation and purification processes, which use solubility as the basic data.…”

Section: Introductionmentioning

confidence: 99%

Solubility and Thermodynamic Properties of Clotrimazole in 16 Organic Solvents at Temperature of 283.15 to 323.15 K

Wang

Yang

et al. 2023

J. Chem. Eng. Data

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In this paper, the solubility of clotrimazole, an antifungal drug, in 10 alcohols (n-propanol, iso-propanol, n-butanol, iso-butanol, sec-butanol, n-pentanol, iso-pentanol, n-hexanol, n-heptanol, and n-octanol) and 6 esters (methyl acetate, ethyl acetate, npropyl acetate, n-butyl acetate, isopropyl acetate, and methyl propionate) was experimentally determined using a laser dynamic solubility-monitoring device in a temperature range of 283.15 to 323.15 K at atmospheric pressure. The functions of solubility versus temperature were regressed using three semi-empirical models (modified Apelblat, three-parameter van't Hoff, and λh) and two activity coefficient models (Wilson and NRTL). The results show that all the five models can be used to correlate the solubility of clotrimazole with temperature in these solvents satisfactorily. Furthermore, the thermodynamic mixing properties (Δ mix G, Δ mix H, Δ mix S, ln(γ 1 ∞ ), and H 1 E, ∞ ) were evaluated using the measured solubility values and Wilson model parameters.

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Development and optimization of Clotrimazole‒Rosehip oil nanoethosomal-gel for oral thrush and gingivitis

Cited by 11 publications

References 49 publications

Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Lipid Nanoemulsion-Based Liquisolid Compact Tablets for Oral Delivery of Clotrimazole: Fabrication Strategies, Characterizations, Antimycotic and Toxicological Evaluations

Solubility and Thermodynamic Properties of Clotrimazole in 16 Organic Solvents at Temperature of 283.15 to 323.15 K

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