Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation

Jangdey, Manmohan Singh; Gupta, Anshita; Saraf, Shailendra; Saraf, Swarnlata

doi:10.1080/21691401.2016.1247850

Cited by 79 publications

(36 citation statements)

References 26 publications

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“…88 More examples of herbal loaded transferosomes are presented in Table 1. [89][90][91][92][93] Niosome Niosome is a nonionic nanosphere vesicle with a diameter of 100 nm to 2 um, in which its center is watery that surrounded by layers of nonionic amphiphilic lipids in lamellar phase ( Figure 5C). 94 It is prepared by thin-film hydration method, sonication, microfluidization, multiple membrane extrusion, reverse phase evaporation technique, remote loading, bubble method and proniosome pre-formulation technique.…”

Section: Transferosomementioning

confidence: 99%

Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications

Rahman

Othman

Hammadi

et al. 2020

IJN

145

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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Section: Transferosomementioning

confidence: 99%

Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications

Rahman

Othman

Hammadi

et al. 2020

IJN

145

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“…FT-IR Spectroscopy: Prepared nanovesicles was evaluated by FTIR spectroscopy. The translucent pellet was prepared by using each sample by grinding and mixing with KBr powder and proceed for scanned over the wavenumber having a range of 400-4000 cm -1 by using FT-IR Spectrophotometer (Shimadzu Bruker Alpha -II FTIR) 21 .…”

Section: Physico-chemical Characterization Of Ma-qulpsmentioning

confidence: 99%

Untitled

2019

IJPSR

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The solar UV radiation is the major trigger factor that causes skin cancer. Nearly 65% of cases of melanoma occurs dues to high exposure to the UV radiation. It also accounts for 90% of the nonmelanoma skin cancers also referred to as NMSC also including the cases of basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). The rate of malignancy in other cases has seemed to get reduced but this is not the situation in case of NMSC, which seemed to have increased and also affect people of younger ages. Cases of NMSC can be accounted for 15,000 deaths in the USA alone. This is surely one of the major health concerns of the nation also. In order to find a solution to this problem a new form of drug delivery system using the specific ligand that has receptor on the surface or the target cells is being proposed. The current discussion deals with the making of the mannosylated quercetin loaded liposomes that can be used for targeting cancerous cells. The methods of transmission electron microscopy (TEM) used for the surface morphology. The MTT assay was done against two different cell lines so that their cancer-preventive or curative properties can be assured. The research, hence establishes the fruitful development of Mannosylated Quercetin loaded liposomes (MA-QuLps) for the targeting of the skin cancer cells.

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“…According to the results of single factor test and Plackett-Burman experiment, the effect of each process variable on viable counts and encapsulation yield of B. bifidum BB01 microcapsules (XC) was further evaluated systematically using a three-factor, three-level Box-Behnken model in this study [21]. Batch experiments with different chitosan concentration (0.8, 0.9 and 1.0 gÁmL À1 ), xanthan containing B. bifidum BB01 XBM/chitosan (1:7, 1:8 and 1:9), stirring time (40, 50 and 60 min) were conducted to cover all the variables for determining the relative contribution of each one of these on the viable counts (Y 1 ) and encapsulation yield (Y 2 ).…”

Section: Box-behnken Design (Bbd) and Statistical Analysismentioning

confidence: 99%

Microencapsulation of Bifidobacterium bifidum BB01 by xanthan–chitosan: preparation and its stability in pure milk

Shu

Chen

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Xanthan-chitosan (XC) and xanthan-chitosan-xanthan (XCX) were employed for microencapsulation of Bifidobacterium bifidum BB01 using extrusion technique. To optimize the process of B. bifidum BB01 microcapsules based on XC hydrogels, response surface methodology was employed to obtain the best possible combination of chitosan concentration, xanthan-B. bifidum BB01 mixture (XBM)/chitosan, stirring time for the maximum viable count and encapsulation yield. The optimum conditions were: chitosan concentration of 0.84 g·mL, XBM/chitosan of 1:9.0, stirring time of 60 min with high viable count and encapsulation yield of 1.52 ± 0.15 × 10CFU·g, 90 ± 0.65%, respectively. In addition, the effective encapsulation system (XC and XCX) resulted in improvement in survival of B. bifidum BB01 compared to non-encapsulated cells during 3 weeks storage at 4 and 25 °C in pure milk.

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Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation

Cited by 79 publications

References 26 publications

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

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Microencapsulation of Bifidobacterium bifidum BB01 by xanthan–chitosan: preparation and its stability in pure milk

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