Development and Implementation of a Web-Based International Registry Dedicated to Atypical Pigmented Skin Lesions of the Face: Teledermatologic Investigation on Epidemiology and Risk Factors

Tognetti, Linda; Cinotti, Élisa; Farnetani, Francesca; Lallas, Aimilios; Paoli, John; Longo, Caterina; Pampena, Riccardo; Moscarella, Elvira; Argenziano, Giuseppe; Tiodorović, Danica; Stanganelli, Ignazio; Magi, Serena; Suppa, Mariano; Marmol, Véronique Del; Dika, Emi; Zelin, Enrico; Zalaudeck, Iris; Pizzichetta, Maria Antonietta; Pellacani, Giovanni; Perrot, Jean; Bertello, Martina; Cataldo, Gennaro; Cevenini, Gabriele; Rubegni, Pietro; Cartocci, Alessandra

doi:10.1089/tmj.2022.0456

Cited by 5 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the last decades, an increasing trend for pigmented facial lesions development has been documented: progressive population ageing and inappropriate sun exposure habits has been indicated as possible contributing factors. [1][2][3] Then, the differential diagnosis between benign and malignant aPFLs, especially when the lesions develop on mottled chronic sun-damaged skin and/or when they display atypical appearance, can be challenging. 4,5 Indeed, some benign pigmented facial lesions may exhibit under the dermatoscope similar features to malignant lesions.…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…We previously set up a registry (the iDScore facial dataset) of 1197 aPFL cases excised with a clinical suspicion of malignancy, all having the dermoscopic pictures integrated with the clinical data. 3 Each case was composed of a standardized dermoscopic image (clinical pictures were additionally available in 60% of cases) and four objective data: maximum diameter (mm), age (years), sex (male/female) and facial site. The face was divided into a 6-area-orbital area, forehead, nose, cheek, chin, mouth area-classification (Figure 1) by taking into account both skin morphology, aesthetics and anatomical features, as routinely done in plastic surgery.…”

Section: E Xperimental De S Ig Nmentioning

confidence: 99%

“…iDScore facial project, https://en.idsco re.net/proje cts/facia l-lesio ns/facia l-lesio ns-2021). 3,4 Based on self-assessment, the evaluators declared different levels of experience in dermoscopy, that is, <1 year (n = 34), 1-4 years (n = 44), 5-8 years (n = 22) and >8 years (n = 54). 4 The pattern analysis relied on recognition of presence/absence of a series of 14 dermoscopic features in each dermoscopic photo.…”

Section: E Xperimental De S Ig Nmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

“…Pattern analysis was performed by either dermatologists ( n = 102) or dermatology residents ( n = 52) through an online tele‐dermoscopic test specifically designed and hosted on a dedicated web platform (i.e. iDScore facial project , https://en.idscore.net/projects/facial-lesions/facial-lesions-2021).3) 3,4 . Based on self‐assessment, the evaluators declared different levels of experience in dermoscopy, that is, <1 year ( n = 34), 1–4 years ( n = 44), 5–8 years ( n = 22) and >8 years ( n = 54) 4 .…”

Section: Experimental Designmentioning

confidence: 99%

See 4 more Smart Citations

Dermoscopy of atypical pigmented lesions of the face: Variation according to facial areas

Tognetti,

Cartocci,

Cinotti

et al. 2023

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

Atypical pigmented facial lesions (aPFLs)—including lentigo maligna (LM) and lentigo maligna melanoma (LMM), solar lentigo (SL), pigmented actinic keratosis (PAK), atypical nevi (AN), seborrheic keratosis (SK) and lichen planus‐like keratosis (LPLK)—can exhibit clinical and dermoscopic overlapping features. We aimed to investigate if and how 14 dermoscopic features suggestive for the aforementioned aPFLs vary according to six facial sites among 1197 aPFLs cases (excised to rule out malignancy) along with lesion and patients' metadata. According to distribution and association analysis, aPFLs on the forehead of a male patient aged > 69 years displaying the obliterated follicular openings pattern, appear to be more at risk of malignancy. Of converse, aPFLs of the orbital/cheek/nose area with evident and regular follicular openings with diameter < 10 mm in a female aged below 68 are probably benign. The obliterated follicular openings, keratin plugs, evident and regular follicular openings and target‐like pattern features differed significantly among six facial areas in all aPFLs cases. Lesion of the nose may show both features suggestive of malignancy and benignity (e.g. many SL and PAK may display target‐like pattern and some LM/LMM cases display keratin plugs and evident and follicular openings), making these features less specific.

show abstract

Section: Backg Rou N Dmentioning

confidence: 99%

Section: E Xperimental De S Ig Nmentioning

confidence: 99%

Section: E Xperimental De S Ig Nmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

See 3 more Smart Citations

Dermoscopy of atypical pigmented lesions of the face: Variation according to facial areas

Tognetti,

Cartocci,

Cinotti

et al. 2023

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

show abstract

A risk‐scoring model for the differential diagnosis of lentigo maligna and other atypical pigmented facial lesions of the face: The facial iDScore

Tognetti,

Cartocci,

Żychowska

et al. 2023

Acad Dermatol Venereol

Self Cite

View full text Add to dashboard Cite

BackgroundDue to progressive ageing of the population, the incidence of facial lentigo maligna (LM) of the face is increasing. Many benign simulators of LM and LMM, known as atypical pigmented facial lesions (aPFLs—pigmented actinic keratosis, solar lentigo, seborrheic keratosis, seborrheic‐lichenoid keratosis, atypical nevus) may be found on photodamaged skin. This generates many diagnostic issues and increases the number of biopsies, with a subsequent impact on aesthetic outcome and health insurance costs.ObjectivesOur aim was to develop a risk‐scoring classifier‐based algorithm to estimate the probability of an aPFL being malignant. A second aim was to compare its diagnostic accuracy with that of dermoscopists so as to define the advantages of using the model in patient management.Materials and MethodsA total of 154 dermatologists analysed 1111 aPFLs and their management in a teledermatology setting: They performed pattern analysis, gave an intuitive clinical diagnosis and proposed lesion management options (follow‐up/reflectance confocal microscopy/biopsy). Each case was composed of a dermoscopic and/or clinical picture plus metadata (histology, age, sex, location, diameter). The risk‐scoring classifier was developed and tested on this dataset and then validated on 86 additional aPFLs.ResultsThe facial Integrated Dermoscopic Score (iDScore) model consisted of seven dermoscopic variables and three objective parameters (diameter ≥ 8 mm, age ≥ 70 years, male sex); the score ranged from 0 to 16. In the testing set, the facial iDScore‐aided diagnosis was more accurate (AUC = 0.79 [IC 95% 0.757–0.843]) than the intuitive diagnosis proposed by dermatologists (average of 43.5%). In the management study, the score model reduced the number of benign lesions sent for biopsies by 41.5% and increased the number of LM/LMM cases sent for reflectance confocal microscopy or biopsy instead of follow‐up by 66%.ConclusionsThe facial iDScore can be proposed as a feasible tool for managing patients with aPFLs.

show abstract

A European Multicentric Investigation of Atypical Melanocytic Skin Lesions of Palms and Soles: The iDScore-PalmoPlantar Database

Tognetti,

Cartocci,

Lallas

et al. 2024

Diagnostics

Self Cite

View full text Add to dashboard Cite

Background: The differential diagnosis of atypical melanocytic palmoplantar skin lesions (aMPLs) represents a diagnostic challenge, including atypical nevi (AN) and early melanomas (MMs) that display overlapping clinical and dermoscopic features. We aimed to set up a multicentric dataset of aMPL dermoscopic cases paired with multiple anamnestic risk factors and demographic and morphologic data. Methods: Each aMPL case was paired with a dermoscopic and clinical picture and a series of lesion-related data (maximum diameter value; location on the palm/sole in 17 areas; histologic diagnosis; and patient-related data (age, sex, family history of melanoma/sunburns, phototype, pheomelanin, eye/hair color, multiple/dysplastic body nevi, and traumatism on palms/soles). Results: A total of 542 aMPL cases—113 MM and 429 AN—were collected from 195 males and 347 females. No sex prevalence was found for melanomas, while women were found to have relatively more nevi. Melanomas were prevalent on the heel, plantar arch, and fingers in patients aged 65.3 on average, with an average diameter of 17 mm. Atypical nevi were prevalent on the plantar arch and palmar area of patients aged 41.33 on average, with an average diameter of 7 mm. Conclusions: Keeping in mind the risk profile of an aMPL patient can help obtain a timely differentiation between malignant/benign cases, thus avoiding delayed and inappropriate excision, respectively, with the latter often causing discomfort/dysfunctional scarring, especially at acral sites.

show abstract

Development and Implementation of a Web-Based International Registry Dedicated to Atypical Pigmented Skin Lesions of the Face: Teledermatologic Investigation on Epidemiology and Risk Factors

Cited by 5 publications

References 22 publications

Dermoscopy of atypical pigmented lesions of the face: Variation according to facial areas

Dermoscopy of atypical pigmented lesions of the face: Variation according to facial areas

A risk‐scoring model for the differential diagnosis of lentigo maligna and other atypical pigmented facial lesions of the face: The facial iDScore

A European Multicentric Investigation of Atypical Melanocytic Skin Lesions of Palms and Soles: The iDScore-PalmoPlantar Database

Contact Info

Product

Resources

About