Development and evaluation of antiobesity polyherbal granules: A full spectrum weight management concept

Patel, Chirag; Shahgond, Lalita; Ahir, Pankita; Acharya, Sanjeev

doi:10.1016/j.obmed.2020.100299

Cited by 1 publication

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“…The preliminary evaluation of extract and herbal granules resulted in satisfactory results. Individual toxicology study of each extract is reported in the literature to a certain extent, however, the toxicity of combination in the form PHG remains unknown (Patel et al, 2020). In this study, we performed acute and 28-day repeated dose toxicity in Sprague Dawley rats.…”

Section: Discussionmentioning

confidence: 99%

“…Our group has formulated and characterized ready-todrink PHG and further evaluated its therapeutic efficacy in high-fat-diet-(HFD) induced obese rats. We reported that 0.3 g/kg granules significantly lowered the body and adipose tissue weight and plasma TC and TG levels in comparison to the HFD control group (Patel et al, 2020). This study was intended to assess acute and sub-acute toxicity of anti-obesity PHG granules in Sprague Dawley rats.…”

Section: Introductionmentioning

confidence: 99%

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Acute and sub-acute toxicity study of anti-obesity herbal granules in Sprague Dawley rats

Patel¹,

Shukla

Pande³

et al. 2024

Braz. J. Biol.

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Toxicological studies are essential for developing novel medications in pharmaceutical industries including ayurvedic preparation. Hence, the present study is aimed to evaluate acute and 28-days repeated dose oral toxicity of anti-obesity polyherbal granules (PHG) in Sprague Dawley rats by OECD guidelines No 425 and 407, respectively. In an acute oral toxicity study, a single dose of 2 g/kg PHG was administered to rats and mortality, body weight, and clinical observations were noted for fourteen days. However, in the subacute oral toxicity study, the PHG was administered orally at doses of 0.3, 0.5 and 1 g/kg daily for 28 days to rats. Food intake and body weight were recorded weekly. On the 29th day, rats were sacrificed and subjected to haematological, biochemical, urine, necropsy, and histopathological analysis. In an acute oral toxicity study, no treatment-related, mortality, behavioral changes, and toxicity were found throughout fourteen days. Likewise, in the sub-acute toxicity study, no mortality and toxic effects were found in haematology, biochemical, urine, necropsy and histopathological analysis in rats for 28 days of treatment with PHG. Based on these results, the LD50 of PHG was found to be greater than 2 g/kg and the no-observed-adverse-effect level (NOAEL) of PHG for rats was found to be 0.5 g/kg/day. Thus, anti-obesity polyherbal granules showed a good safety profile in animal studies and can be considered an important agent for the clinical management of obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%