Development and Distribution of Lysosomal Enzymes and Disaccharidases in Human Fetal Intestine

Antonowicz, Irena; Chang, Sin Kai; Grand, Richard J.

doi:10.1016/s0016-5085(19)32925-7

Cited by 92 publications

(16 citation statements)

References 34 publications

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“…The recorded profile illustrated in Fig. 3 is in agreement with that reported for many lysosomal enzymes, including acid-P-galactosidase, in developing human fetal jejunum [29]. Few data are available regarding the modulators involved in the development of acid-b-galactosidase activity in rats [30] and none for human.…”

Section: Discussionsupporting

confidence: 86%

The expression of lactase enzymatic activity and mRNA in human fetal jejunum Effect of organ culture and of treatment with hydrocortisone

et al. 1992

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Very sensitive procedures were developed for the parullel determination of intestinal lactase (LPH) activity and the cognate mRNA. Between 14 and 20 weeks of gestation, lactase activity is low and varies only slightly; at 37 weeks, a relatively high level of activity is observed. The amounts of LPH mRNA correlates with the enzymatic activity (r = 0.64). Culture of fetal jejunal explants for 5 days induces by itself a 2.fold increase in LPI-I mRNA, without any significant change in lactase enzymatic activity. This increase may reflect the loss ofa negative transcriptional regulation opcldtive in vivo, and suggests an additional post-transcriptional regulatory componenl, The addition of hydrocortisone (50 n&/ml) during culture induces a doubling of lactuse activity without variation in LHP mRNA, indicating a post-transcriptional modulation by hydrocortisone, The intestinal lysosomal ucid &guluctosidase activity wus shown to bc unaffected by hydrocortisone treatment. This observation clearly illustrates that the two intestinal P~galactosidascs are regulated differently. Our results suggests a complex developmental regulation of human intestinal lactase and [hut the perinatal increase in lactase activity could be modulated at a post-transcriptional level by hydrocortisone.

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Section: Discussionsupporting

confidence: 86%

The expression of lactase enzymatic activity and mRNA in human fetal jejunum Effect of organ culture and of treatment with hydrocortisone

et al. 1992

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“…1-3 In spite of data47 which emphasised the precocious morpho-logical5 8-10 and especially enzymatic maturation [11][12][13][14] in the course of human intestinal development, the precise onset of brush border enzyme function in the small intestine needed to be defined.…”

mentioning

confidence: 99%

Early organogenesis of human small intestine: scanning electron microscopy and brush border enzymology.

Kédinger¹,

Simon‐Assmann²,

Haffen³

1984

Gut

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SUMMARY Human small bowel early organogenesis was studied by scanning electron microscopy and found to be correlated to brush border enzymology. The appearance of the brush border enzymes sucrase, lactase, and aminopeptidase (measured in a purified apical membrane fraction) coincides with the first outgrowth of villi (eight weeks). Alkaline phosphatase was detected at seven weeks. The content of these enzymes furthermore increased up to the 14th week when both sucrase and aminopeptidase activities were comparable with adult values.The maturation events occurring during ontogenesis of the gut and the factors involved in their control have been mainly studied in rodents.

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“…Fetal swallowing has been observed at 12 weeks of age (Mori 1956) and at mid-pregnancy (Abramovich 1970). Intestinal lysosomal activity in 10-week-old embryos is the same as after birth (Antonowicz et al 1974). As the gut endoderm is derived from the visceral yolk sac endoderm, it seems probable that these two structures develop the same role for the absorption of nutrients to the fetus (the yolk sac mainly in rodents) from the amniotic, and the uterine cavities, respectively.…”

Section: Discussion Crnbray Omentioning

confidence: 87%

Tissue Localization of Some Teratogwns at Early and Late Gestation Related to Fetal Effects

Dencker¹

1976

Acta Pharmacologica et Toxicologica

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Development and Distribution of Lysosomal Enzymes and Disaccharidases in Human Fetal Intestine

Cited by 92 publications

References 34 publications

The expression of lactase enzymatic activity and mRNA in human fetal jejunum Effect of organ culture and of treatment with hydrocortisone

The expression of lactase enzymatic activity and mRNA in human fetal jejunum Effect of organ culture and of treatment with hydrocortisone

Early organogenesis of human small intestine: scanning electron microscopy and brush border enzymology.

Tissue Localization of Some Teratogwns at Early and Late Gestation Related to Fetal Effects

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