Development and Application of Diagnostics in the National Schistosomiasis Control Programme in The People's Republic of China

Zhang, J.-F.; Xu, Jing; Bergquist, Robert; Yu, Liping; Yan, Xiao-lan; Zhu, Hongqing; Wen, Li-yong

doi:10.1016/bs.apar.2016.02.008

Cited by 31 publications

(24 citation statements)

References 58 publications

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“…A number of papers reviewed the available diagnostic approaches for schistosomiasis, finding room for improvement with each [95][96][97][98][99][100][101]. Subsequently, the emerging consensus is for a stratified approach, by which difference test combinations are deployed for different use cases and tailored to the exigencies of national programmes [96,[102][103][104][105][106]. In this context, the correct question for schistosomiasis elimination is not "What is the best tool?"…”

Section: Box 4 Elimination Goals For Schistosomiasismentioning

confidence: 99%

NTD Diagnostics for Disease Elimination: A Review

Taylor

2020

Diagnostics

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Neglected Tropical Diseases (NTDs) marked out for disease elimination provide a lens through which to explore the changing status of diagnosis in global health. This paper reports on the findings of a scoping review, which set out to explore the main debates around diagnosis for the elimination of NTDs, including the multiple roles diagnostic technologies are being ascribed and the ideal characteristics of tests. It also attempts to summarise the state of diagnosis for three NTDs with elimination goals. The review places special emphasis on point-of-care testing in acknowledgement of the remote and underserved areas where NTDs proliferate. Early NTD campaigns were largely focused on attack phase planning, whereby a similar set of interventions could be transplanted anywhere. Now, with elimination goals in sight, strategies must be tailored to local settings if they are to attain and sustain success. Diagnostic data helps with local adaptation and is increasingly used for programmatic decision-making. The review finds that elimination goals reframe whom diagnosis is for and the myriad roles diagnostics can play. The exigencies of elimination also serve to highlight deficiencies in the current diagnostic arsenal and development pipeline for many NTDs. Moving forward, a guiding framework is needed to drive research and stimulate investment in diagnosis to support NTD goals.

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Section: Box 4 Elimination Goals For Schistosomiasismentioning

confidence: 99%

NTD Diagnostics for Disease Elimination: A Review

Taylor

2020

Diagnostics

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“…Currently, the Kato-Katz technique and miracidium hatching test remain the gold standard for the diagnosis of S. japonicum human infection [85]. However, these two techniques exhibit a high missing rate in detecting S. japonicum infections, notably in low-intensity regions [43].…”

Section: Discussionmentioning

confidence: 99%

A multidisciplinary, integrated approach for the elimination of schistosomiasis: a longitudinal study in a historically hyper-endemic region in the lower reaches of the Yangtze River, China from 2005 to 2014

Wang

YinPing³

et al. 2017

Infect Dis Poverty

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BackgroundAlthough great success has been achieved, schistosomiasis remains a major public health concern in China, and the remaining core endemic regions are concentrated along the middle and lower reaches of the Yangtze River. In this longitudinal study, we evaluated the effectiveness of a multidisciplinary, integrated approach for schistosomiasis elimination in a historically hyper-endemic region in the lower reaches of the Yangtze River, China over the 10-year period from 2005 through 2014.MethodsA three-step roadmap for schistosomiasis elimination was designed in the study site, and multidisciplinary, integrated interventions were implemented by the health, agriculture, water resources development, land and resources, and forestry sectors from 2005 to 2014, including chemotherapy for infected individuals, health education, management of the source of Schistosoma japonicum infection, and intermediate host snail control. The annual number of schistosomiasis patients, S. japonicum infection in humans, bovines and Oncomelania hupensis snails, and water infectivity were observed to assess the effectiveness of the multidisciplinary, integrated approach for the elimination of schistosomiasis.ResultsThere was a tendency towards a gradual decline in both the number of schistosomiasis cases and the prevalence of S. japonicum human infection across the study period from 2005 through 2014. No S. japonicum human infection was detected since 2012, and no acute infection was seen since 2006. During the study period, no infection was found in bovines, and a 0.03% overall infection rate was observed in O. hupensis snails. Since 2009, no infected snails were identified, and the area of both snail habitats and infected snail habitats appeared a reduction over the study period. Following the 3-year multidisciplinary, integrated control, infection control was achieved, and transmission control was achieved after 6-year implementation, with all infected snails and water infectivity eliminated; in addition, the 10-year implementation resulted in interruption of schistosomiasis transmission in the study site in 2014.ConclusionsThe results of the present 10-year longitudinal study demonstrate that the multidisciplinary, integrated approach is effective for the elimination of schistosomiasis as a public health problem in the lower reaches of the Yangtze River, China.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-017-0270-x) contains supplementary material, which is available to authorized users.

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“…Residents in endemic villages were first screened by the indirect haemagglutination (IHA) serology test and those found to be positive were further tested by the faecal Kato-Katz parasitological test, currently the gold standard for diagnosis of S. japonicum [23]. …”

Section: Methodsmentioning

confidence: 99%

Village-based spatio-temporal cluster analysis of the schistosomiasis risk in the Poyang Lake Region, China

Chen

Bergquist²,

Lynn

et al. 2017

Parasites Vectors

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BackgroundThe Poyang Lake Region, one of the major epidemic sites of schistosomiasis in China, remains a severe challenge. To improve our understanding of the current endemic status of schistosomiasis and to better control the transmission of the disease in the Poyang Lake Region, it is important to analyse the clustering pattern of schistosomiasis and detect the hotspots of transmission risk.ResultsBased on annual surveillance data, at the village level in this region from 2009 to 2014, spatial and temporal cluster analyses were conducted to assess the pattern of schistosomiasis infection risk among humans through purely spatial (Local Moran’s I, Kulldorff and Flexible scan statistic) and space-time scan statistics (Kulldorff). A dramatic decline was found in the infection rate during the study period, which was shown to be maintained at a low level. The number of spatial clusters declined over time and were concentrated in counties around Poyang Lake, including Yugan, Yongxiu, Nanchang, Xingzi, Xinjian, De’an as well as Pengze, situated along the Yangtze River and the most serious area found in this study. Space-time analysis revealed that the clustering time frame appeared between 2009 and 2011 and the most likely cluster with the widest range was particularly concentrated in Pengze County.ConclusionsThis study detected areas at high risk for schistosomiasis both in space and time at the village level from 2009 to 2014 in Poyang Lake Region. The high-risk areas are now more concentrated and mainly distributed at the river inflows Poyang Lake and along Yangtze River in Pengze County. It was assumed that the water projects including reservoirs and a recently breached dyke in this area were partly to blame. This study points out that attempts to reduce the negative effects of water projects in China should focus on the Poyang Lake Region.

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Development and Application of Diagnostics in the National Schistosomiasis Control Programme in The People's Republic of China

Cited by 31 publications

References 58 publications

NTD Diagnostics for Disease Elimination: A Review

NTD Diagnostics for Disease Elimination: A Review

A multidisciplinary, integrated approach for the elimination of schistosomiasis: a longitudinal study in a historically hyper-endemic region in the lower reaches of the Yangtze River, China from 2005 to 2014

Village-based spatio-temporal cluster analysis of the schistosomiasis risk in the Poyang Lake Region, China

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