Developing vaccines against epidemic-prone emerging infectious diseases

Bernasconi, Valentina; Kristiansen, Paul A.; Whelan, Mike; Román, Raúl Gómez; Bettis, Alison A.; Yimer, Solomon Abebe; Gurry, Céline; Andersen, Svein Rune; Yeskey, Debra; Mandi, Henshaw; Kumar, Arun; Holst, Johan; Clark, Charles C.; Cramer, Jakob P.; Røttingen, John-Arne; Hatchett, Richard; Saville, Mélanie; Norheim, Gunnstein

doi:10.1007/s00103-019-03061-2

Cited by 34 publications

(33 citation statements)

References 21 publications

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“…Lassa fever has been recognized by the World Health Organization (WHO) as an important threat to global health that is in urgent need of countermeasure development 13 . The Coalition for Epidemic Preparedness Innovations (CEPI) has prioritized the accelerated development of a Lassa fever vaccine 14,15 . CEPI has also initiated an epidemiological study in five West African countries as part of their strategy to facilitate vaccine development efforts 16 .…”

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confidence: 99%

Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages

Heinrich

Boisen

Nelson

et al. 2020

Sci Rep

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Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhagic disease that is endemic in West Africa. Seven genetically distinct LASV lineages have been identified. As part of CEPI’s (Coalition for Epidemic Preparedness Innovations) Lassa vaccine development program, we assessed the potential of the human immune system to mount cross-reactive and cross-protective humoral immune responses to antigens from the most prevalent LASV lineages, which are lineages II and III in Nigeria and lineage IV in Sierra Leone. IgG and IgM present in the blood of Lassa fever survivors from Nigeria or Sierra Leone exhibited substantial cross-reactivity for binding to LASV nucleoprotein and two engineered (linked and prefusion) versions of the glycoproteins (GP) of lineages II–IV. There was less cross-reactivity for the Zinc protein. Serum or plasma from Nigerian Lassa fever survivors neutralized LASV pseudoviruses expressing lineage II GP better than they neutralized lineage III or IV GP expressing pseudoviruses. Sierra Leonean survivors did not exhibit a lineage bias. Neutralization titres determined using LASV pseudovirus assays showed significant correlation with titres determined by plaque reduction with infectious LASV. These studies provide guidance for comparison of humoral immunity to LASV of distinct lineages following natural infection or immunization.

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confidence: 99%

Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages

Heinrich

Boisen

Nelson

et al. 2020

Sci Rep

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“…In the literature, many different researchers also argued that technological infrastructure of a country has a positive in uence on coping with the pandemics. Bernasconi et al [24] made a study for emerging pandemics. They aimed to understand the ways to stop these problems as soon as possible.…”

Section: Discussionmentioning

confidence: 99%

“…Details of these criteria are given in Table 1. Economic Conditions (criterion 1) [22], [23] Technological Infrastructure (criterion 2) [24], [25] Capacity of health system (criterion 3) [26], [27] Production Capacity (criterion 4) [28] Social (Dimension 2) Population (criterion 5) [29], [30], [31] Social Distance (criterion 6) [32], [33] Tendency of Obeying Rules (criterion 7) [34], [35] Density of elderly people and chronic diseases (criterion 8) [36], [37] As can be seen from Table 1, the economic performance of the country is of great importance in order to effectively ght epidemic diseases. In the process of combating pandemic diseases, many different costs will arise.…”

Section: Methodsmentioning

confidence: 99%

“…The main way to get rid of this type of problem with minimal damage is to nd the vaccine to treat the diseases. Technologically equipped countries are making faster progress in the production of necessary vaccines, as a result of which they are in a better position in combating the pandemic [24]. However, as the vaccine will take time in the process of these rapidly spreading diseases, besides the vaccine, one of the features required to manage the pandemic period well is the adequacy of the country's equipment such as laboratories, assay kits and respirators [25].…”

Section: Literature On Technical Factorsmentioning

confidence: 99%

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Multi-dimensional Strategic Approach to the Communicable Diseases With Systemic Risks by Using IT2 Fuzzy Decision-making Modelling

Wang¹,

Yang²,

Yüksel³

et al. 2020

Preprint

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Background Communicable diseases lead to significant social and financial burden for the countries. Therefore, countries should define their social and technical factors for struggling these problems. The main purpose of this study is to determine the effective strategies to minimize socio-economic burden of these diseases. Methods For this purpose, 8 different criteria are identified based on the literature analysis. In the evaluation process, the significance levels of these factors are calculated by considering interval-valued intuitionistic fuzzy (IVIF) DEMATEL. Findings: The findings show that technological infrastructure, social distance, and tendency of obeying rules are the most significant items to control these problems. This situation explains that countries should have the necessary equipment to make the diagnosis quickly and effectively. In addition, countries that have effective laboratories in which vaccines and drugs can be developed can be more successful in combating these pandemics. Additionally, it is also defined that cultural factors play also key role to control these problems. Conclusions In this framework, it is vital that the people in the country take the rules set by the government seriously and without exception. For this purpose, it should be explained to citizens living in the country that personal hygiene, social distance and not entering crowded environments are very important to manage these problems. For this purpose, role model people in the country can be preferred in different platforms so that it can be more effective on the citizens.

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Section: Methodsmentioning

confidence: 99%

Multi-dimensional strategic approach to the communicable diseases with systemic risks by using IT2 fuzzy decision-making modelling

Wang

Yang

Yüksel

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Communicable diseases lead to significant social and financial burden for the countries. Therefore, countries should define their social and technical factors for struggling these problems. The main purpose of this study is to determine the effective strategies to minimize socio-economic burden of these diseases.Methods: For this purpose, 8 different criteria are identified based on the literature analysis. In the evaluation process, the significance levels of these factors are calculated by considering interval-valued intuitionistic fuzzy (IVIF) DEMATEL. Results: The results show that technological infrastructure, social distance, and tendency of obeying rules are the most significant items to control these problems. This situation explains that countries should have the necessary equipment to make the diagnosis quickly and effectively. In addition, countries that have effective laboratories in which vaccines and drugs can be developed can be more successful in combating these pandemics. Additionally, it is also defined that cultural factors play also key role to control these problems. Conclusions: In this framework, it is vital that the people in the country take the rules set by the government seriously and without exception. For this purpose, it should be explained to citizens living in the country that personal hygiene, social distance and not entering crowded environments are very important to manage these problems. For this purpose, role model people in the country can be preferred in different platforms so that it can be more effective on the citizens.

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Developing vaccines against epidemic-prone emerging infectious diseases

Abstract: · ZusammenfassungBundesgesundheitsbl 2020 · 63:65-73 https://doi.

Cited by 34 publications

References 21 publications

Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages

Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages

Multi-dimensional Strategic Approach to the Communicable Diseases With Systemic Risks by Using IT2 Fuzzy Decision-making Modelling

Multi-dimensional strategic approach to the communicable diseases with systemic risks by using IT2 fuzzy decision-making modelling

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