1997
DOI: 10.1074/jbc.272.4.2291
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Abstract: Conantokin-G and conantokin-T are two paralytic polypeptide toxins originally isolated from the venom of the fish-hunting cone snails of the genus Conus. Conantokin-G and conantokin-T are the only naturally occurring peptidic compounds which possess N-methyl-D-aspartate receptor antagonist activity, produced by a selective non-competitive antagonism of polyamine responses. They are also structurally unusual in that they contain a disproportionately large number of acid labile post-translational ␥-carboxyglutam… Show more

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Cited by 71 publications
(26 citation statements)
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References 32 publications
(26 reference statements)
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“…Figure 6 shows the predicted structure for EAR18 and EAR16 and the one reported for conantokin-G [47, 48]. While conantokin-G adopts a helical conformation in more than 70% of its sequence [47, 48], EAR18 and EAR16 adopt a helical conformation in 50% (EAR18) or less (EAR16) of their sequence. The high level of helical conformation in conantokin-G is due to the presence of Gla, which coordinates binding of 4 calcium ions [4850].…”
Section: Discussionmentioning
confidence: 99%
“…While conantokin-G adopts a helical conformation in more than 70% of its sequence [47, 48], EAR18 and EAR16 adopt a helical conformation in 50% (EAR18) or less (EAR16) of their sequence. The high level of helical conformation in conantokin-G is due to the presence of Gla, which coordinates binding of 4 calcium ions [4850]. The decrease in the proportion of helical conformation will increase the molecular flexibility of EAR18 and EAR16 and this may contribute to the observed high reversibility of EAR16 and EAR18 (present study).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…CGU = Gla: γ-carboxyglutamic acid. Conantokins adopt an α-helical solution structure in the presence of divalent cations in which charged carboxyl groups of the Gla residues are positioned along one face of the helix and hydrophobic residues are on the opposite face [83]. Figures were created with Pymol [82] (PDB 1ONT and 1ONU for Con-T and Con-G, respectively) …”
Section: Conantokinsmentioning
confidence: 99%
“…The conantokins (G, L, R and T) form a class of peptides that inhibit competitively NMDA receptors [79,80]. Interestingly conantokins possess a large number of γ-carboxyglutamic acid residues (Figure 7) [81]. One of the γ−carboxyglutamic acid residues is thought to participate in the selectivity of conantokin G [82].…”
Section: Toxins Targeting the Ligand Gated Ion Channelsmentioning
confidence: 99%