Determination of the Liver Enzymes Level and Kidney Functions in Pregnant Women in the Second Trimester of Pregnancy at Different Age Groups

Abstract

The level of liver enzymes and kidney functions in pregnant women in the second trimester of pregnancy at different age groups was determined. This study is composed of fifty pregnant women in the second trimester of pregnancy and were classified into two subgroups; first group included twenty-five pregnant with an age between 22-30 years, a second group included twenty-five pregnant with an age 35-42 years. A control group included twenty-five non-pregnant, healthy women was also included. Blood samples were obtained from each group, centrifuged, serum was collected from each group to measure liver enzymes (AST, ALT and ALP) and kidney function tests (urea and creatinine) were measured using enzymatic kits. The results of present study illustrated significant elevation (P≤ 0.05) in AST and ALT means in the age group 35-42 years, while there were no-significant differences in an age group 22-30 compared with control healthy group. In addition, the ALP mean values are significantly increase(P≤0.05) in 22-30 and 35-42 years compared with non-pregnant women. The findings also demonstratedthat the means of blood urea is significantly declined (P≤0.05) in the age groups 22-30 and 35-42 years compared with healthy non-pregnant. This studyfoundsignificant decline(P≤0.05) in serum creatinine at an age group 22-30 and significant increase(P≤0.05) in the other group (35-42 years) compared with the control. The conclusion of the present study that hepatic and renal functions are more damaged in an age group 33-42 years than an age group 22-30 years through the values of parameters above. Therefore, pregnancy in the age 22-30 years is more healthyfor both mother and fetus than an age 33-42 years.Keywords: Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, Urea, Creatinine, Pregnancy. ‫ووظائف‬ ‫الكبد‬ ‫انزيمات‬ ‫مستوى‬ ‫تعيين‬ ‫بمجاميع‬ ‫الحمل‬ ‫من‬ ‫الثاني‬ ‫الثمث‬ ‫في‬ ‫امل‬ ‫الحو‬ ‫النساء‬ ‫في‬ ‫الكمى‬ ‫مختمفة‬ ‫عمرية‬ ‫اري‬ ‫الجو‬ ‫الخالق‬ ‫عبد‬ ‫سهى‬ ISSN: 0067-2904Al-Jowary Journal of Science, 2017, Vol. 58, No.4A, pp: 1802-1807 IntroductionPregnancy or gestation in a normal condition occurred in women characterized by many physiological and anatomical alternations in order to prepare appropriate environment for developing the embryo until birth [1,2]. One of the most physiological changes is the elevation in the level of sex steroid hormones which influence on the hepatic functions [1][2][3][4].In addition, kidneys are one of the maternal changes that happened during gestation and haveimpact on fetus [2,3]. Gestation period is divided into three phases; first second and third trimesters. In the second trimester, the development and movement of embryo should monitor in this period [3]. Alternations in hepatic functions for pregnant women are normal, however, the level of liver enzymes which include aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) must determine in each period of pregnancy [4,5]. On the other hand, renal functiontests mus...

Role of Genetic Variants AGT rs699 and ACE2 rs2106809 in Increasing the Risk and Severity of COVID-19 Infection in Iraqi Patients

“…Several proteins, minerals, electrolytes, enzymes and blood biochemical profiles changed during gestation in sheep [11,12] and humans [13] along with changes in some genes expression [14] but it also several genes expressed in response to IFNT, which called Interferon tau Stimulated Genes (ISGs); it critical for conceptus expansion and attachment or implantation, it includes several genes: Interferon-myxovirusresistance 1 (Mx1)1 (Mx1) and 2 (Mx2), ubiquitin-like modifier (ISG15), STAT 1 and 2, radical S-adenosyl methioninecontaining domain (RSAD2), oligoadenylate synthetase 1 (OAS1), receptor transporter protein 4 (RTP4) Interferon regulatory factor 1 (IRF1) and 9 (IRF9) in different maternal tissues and many cell types with vast effects [15][16][17][18].…”