volume 269, issue 1, P81-88 2004
DOI: 10.1016/j.ijpharm.2003.08.015
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Abstract: The change in surface energy of cefditoren pivoxil powder as a consequence of changes in crystallinity (caused by milling duration) was studied using inverse gas chromatography (IGC) under dry conditions. The surface of the powder became more basic with decreasing crystallinity. It was suggested by considering the results of IR spectra that this resulted from exposure of the carbonyl groups, which have electron donating nature, on the particle surface. There was a direct correlation between surface energy and …

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