Determination of potential degradation products of piroxicam by HPTLC densiometry and HPLC

Tománková, Hana; Šabartová, J.

doi:10.1007/bf02319647

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…The voltammograms exhibit an oxidation peak centered at 0.6 V with the corresponding peak net current ( I P ) decreasing over time, indicating that PX is markedly decomposed. This behavior is in agreement with previous reports regarding the stability of PX in aqueous media, in which the degradation of PX was attributed to the influence of pH and light. The synthesis precursor 2‐aminopyridine was found to be the principal degradation product, as well as 2‐methyl‐2H‐1,2‐benzotiazine‐ 4(3 H)‐one‐1,1‐dioxide and N‐methyl‐N0‐(2‐pyridinyl)‐ethane‐diamide …”

Section: Resultssupporting

confidence: 93%

“…Figure 1B shows the SW voltammograms acquired at different times. Thev oltammograms exhibit an oxidation peak centered at 0.6 Vw ith the corresponding peak net current( I P )d ecreasingo ver time, indicating that PX is markedlyd ecomposed.T his behaviori si na greement with previous reports regardingt he stability of PX in aqueous media, [32,38,39] in which the degradation of PX was attributed to the influenceo fp H and light.T he synthesis precursor 2-aminopyridine was found to be the principal degradationp roduct, as well as 2-methyl-2H-1,2-benzotiazine-4(3 H)-one-1,1-dioxide and N-methyl-N0-(2-pyridinyl)-ethane-diamide. [32] PX was then studied in an aqueous solution containing the surfactant Tween 80 and the co-surfactant n-butanol, with the www.chemphyschem.org aim of emulating the medium in which the nanoparticles are suspended ( Figure 1C).…”

Section: Ec Behavior Of Px In Aqueousmediasupporting

confidence: 82%

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Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers

et al. 2016

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A new, simple, and fast electrochemical (EC) method has been developed to determine the release profile of piroxicam, a nonsteroidal anti-inflammatory drug, loaded in a drug delivery system based on nanostructured lipid carriers (NLCs). For the first time, the samples were analyzed by using square wave voltammetry, a sensitive EC technique. The piroxicam EC responses allow us to propose a model that explains the experimental results and to subsequently determine the amount of drug loaded into the NLCs formulation as a function of time. In vitro drug release studies showed prolonged drug release (up to 5 days), releasing 60 % of the incorporated drug. The proposed method is a promising and stable alternative for the study of different drug delivery systems.

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Section: Resultssupporting

confidence: 93%

Section: Ec Behavior Of Px In Aqueousmediasupporting

confidence: 82%

Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers

et al. 2016

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“…Finally, TBPs 1, 2, 13 and 14 are detected only in samples after 240 min of treatment and at low concentration levels and thus they can be considered as later stage products. For the sake of comparison with other studies dealing with the degradation of PRX, TBP 14 and structurally similar TBPs have been identified as degradation products of PRX under oxidative and photolytic conditions . In addition, the in vivo formation of the metabolic oxidation product 5‐hydroxypiroxicam and at least 13 new secondary peaks (without structure identification) after the in vitro study of hydroxyl radical attack of PRX was reported elsewhere …”

Section: Resultsmentioning

confidence: 94%

Sonochemical oxidation of piroxicam drug: effect of key operating parameters and degradation pathways

Lianou

Frontistis

Chatzisymeon

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND Piroxicam (PRX) is a non‐steroidal anti‐inflammatory drug (NSAID) commonly used to relieve pain and swelling of conditions like arthritis. PRX has been extensively detected in seawater, surface, and sewage waters worldwide and therefore its efficient treatment is an issue of emerging concern. In this work, the sonochemical degradation of PRX was investigated. RESULTS All experiments were conducted at constant ultrasound frequency of 20 kHz while the following range of experimental conditions was investigated: initial PRX concentration 320–960 µg L‐1, ultrasound power density 20–60 W L‐1, temperature 20–60 °C, reaction time up to 60 min. The effect of different water matrices, namely surface water (SW), bottled water (BW), ultrapure water (UPW) and humic acid (HA) aqueous solution on process efficiency was also explored. It was found that PRX degradation reached 96% after only 10 min of treatment under the best conditions (i.e. [PRX]0 = 320 mg L‐1, 20 °C, 36 W L‐1) assayed. Power density could positively affect PRX degradation. Nevertheless, PRX degradation decreased when its initial concentration and the temperature of the bulk liquid was increased. PRX degradation was found to decrease, in different water matrices, in the order: UPW > 5 mg L‐1 HA > BW > 10 mg L‐1 HA > SW. High resolution mass spectrometry analysis revealed that 14 transformation by‐products (TBPs) were formed and subsequently degraded during treatment while the PRX degradation pathways were also elucidated. CONCLUSION At the optimal operating conditions assayed, PRX was efficiently degraded after about 10 min of sonochemical oxidation, thus rendering it a promising technology for the treatment of xenobiotics. © 2017 Society of Chemical Industry

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“…While Fini et al [25] considered that change in absorbance, observed in function of time, is probably due to the change of the position of the tautomeric equilibrium with the pH, Bartsch et al [26] and Tománková et al [27] attributed the degradations of piroxicam as a consequence of pH and light influence. The principal product of degradations is the synthesis precursor 2-aminopyridine, as well as 2-methyl-2H-1,2-benzotiazine-4(3H)-one 1,1-dioxide and N-methyl-N 0 -(2-pyridinyl)-ethane-diamide.…”

Section: Stability Of Piroxicam Solutionsmentioning

confidence: 99%

Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode

Torriero

Tonn

Sereno

et al. 2006

Journal of Electroanalytical Chemistry

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Determination of potential degradation products of piroxicam by HPTLC densiometry and HPLC

Cited by 10 publications

References 11 publications

Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers

Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers

Sonochemical oxidation of piroxicam drug: effect of key operating parameters and degradation pathways

Electrooxidation mechanism of non-steroidal anti-inflammatory drug piroxicam at glassy carbon electrode

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