Determination of polyhexamethylene biguanide hydrochloride

Abstract

Polyhexamethylene biguanide hydrochloride (PHMB-HCl) is widely used as a disinfectant in personal care products such as cosmetics and toiletries and as a sanitizer in swimming pools. PHMB-HCl possesses marked characteristics of cationic polyelectrolytes. We have applied unique determination methods to PHMBHCl using its ion association with organic anions and polyanion. In this review, we provide several colloidal titrations and a voltammetric method.

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

“…A variety of analytical methods have been developed for the quantitation of PHMB in various samples, e.g., spectrophotometry, capillary electrophoresis, colorimetric method, liquid chromatography, mass spectrometry, and titrimetric method. 50,[76][77][78][79] UV-vis spectrophotometry provides a simple and fast way to quantify PHMB in aqueous solutions based on the established calibration curve according to the maximum adsorption wavelength (approx. 235 nm).…”

“…Based on this method, Masadome et al examined a series of titrimetric determination methods for PHMB including the Kjeldahl method, non-aqueous titration method, argentometric titration, and colloidal titration. 77,[83][84][85] Colloidal titration can be subdivided into photometric titration and potentiometric titration. Photometric titration involves the use of a color indicator, while potentiometric titration employs an indicator cation.…”

Determination of Polyhexamethylene Biguanide Hydrochloride Using a Lactone-Rhodamine B-Based Fluorescence Optode

“…Polyhexamethylene biguanide hydrochloride (PHMB), a kind of a cationic polyelectrolyte (CP), is very useful for disinfectants in a contact lens detergent (CLD) and sanitizers for swimming pools. Many analytical methods for PHMB have been studied [1][2][3][4][5][6][7][8][9][10][11][12]. However, the lower determination concentration of several analytical methods for PHMB is above a few ppm, and the methods have very tedious operation procedures and use very toxic reagents frequently.…”

Indirect Potentiometric Determination of Polyquaternium Polymer Concentrations by Equilibrium Binding to 1-Dodecyl Sulfate

“…This seminal work was followed by the development of a number of related electrochemical methods for the detection of heparin and other polyions, including polyquaternium polymers. 12,[19][20][21][22][23][24][25][26][27] Timed applied potentials were used to control extraction of protamine from the sample solutions into a membrane, and subsequent stripping, resulted in potential changes characteristic for the protamine concentration. 26,27 This approach could also be applied for the indirect detection of heparin by titration with protamine.…”

“…In this case, the polyion of interest is titrated with a polyion of the opposite charge, resulting in a large decrease in the concentration of the monovalent indicator ions after the endpoint due to binding of those indicator ions to the polyion of opposite charge. [23][24][25] In addition, polycation concentrations have been indirectly measured by monitoring the concentration of free polyanions during binding titrations with both non-reversible and reversible techniques. 19 Automated systems for polyion detection either by nonreversible 20 or reversible 21 techniques have also been described.…”