Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.02.004 View full text
A. Osberghaus, S. Hepbildikler, S. Nath, M. Haindl, E. von Lieres, J. Hubbuch

Abstract: The application of mechanistic modeling for the optimization of chromatographic steps increased recently due to time efficiency of algorithms and rising calculation power. In the modeling of ion exchange chromatography steps, the sorption processes occurring on adsorbent particle surfaces can be simulated with the steric mass action (SMA) model introduced by Brooks and Cramer (1992) [14]. In this paper, two approaches for the determination of SMA parameters will be carried out and discussed concerning their sp…

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