Determination of oxidative stress in thyroid tissue and plasma of patients with Graves' disease

Oxidative Stress in Graves’ Disease

“…More recently, this issue has been re-evaluated in 25 consecutive patients with GD who underwent thyroidectomy by comparing markers of oxidative status between the thyroid tissue and plasma [29]. Mean duration of hyperthyroidism before surgery was 29 months.…”

Increased oxidative DNA damage, lipid peroxidation, and reactive oxygen species in cultured orbital fibroblasts from patients with Graves’ ophthalmopathy: evidence that oxidative stress has a role in this disorder

“…[9][10][11][12][13] Recently, there is growing evidence that a change of reactive oxygen species (ROS) metabolism has been implicated in the aetiopathogenesis of several autoimmune disorders including Graves' disease and GO. [14][15][16] Bednarek et al 17,18 reported that the ROS and antioxidant enzymes were increased in peripheral blood of hyperthyroid patients and euthyroid patients with infiltrative ophthalmopathy. Lu et al 19 detected signals of oxygen free radicals in GO retroocular fibroblasts by using electron paramagnetic resonance spectroscopy.…”

Oxidative stress in patients with Graves' ophthalmopathy: relationship between oxidative DNA damage and clinical evolution

“…[10][11][12] More recently, there is growing evidence that oxidative stress plays an important role in the pathogenesis of Graves' disease. [13][14][15] Graves' disease is characterized by the overproduction of thyroid hormones, which can accelerate the basic metabolic rate and cellular oxidative metabolism by the induction of mitochondrial enzymes and causes ROS overproduction and an increase of oxidative stress. 16 Bednarek et al 17 reported that the increase in oxidative stress parameters, such as hydrogen peroxide, thiobarbituric acid-reactive substances, superoxide dismutase, and catalase in hyperthyroid patients can be normalized after euthyroidism achievement except those with infiltrative ophthalmopathy.…”