Determination of normal splenic volume on computed tomography in relation to age, gender and body habitus

Abstract

The purpose of our study was to examine variations in normal splenic size in relation to age, gender and body habitus in vivo, and to determine normative data for splenic volume on CT. The width (W), length (L), thickness (Th), cross-sectional areas and volume (Vol) of the spleen were obtained from abdominal CT examinations of 140 patients who underwent CT for indications unrelated to splenic disease. Splenic volume did not vary significantly (-0.04 < r < 0.05, p > 0.10) with the patient's age, gender, height, weight, body mass index or the diameter of the first lumbar vertebra, the latter considered as representative of body habitus on CT. The mean value of the measured splenic volume (S Vol) was 214.6 cm3 with a range from 107.2 to 314.5 cm3. S Vol correlated well with all the linear and the maximal cross-sectional area measurements and could be calculated using the formula: S Vol = 30 + 0.58 (W x L x Th.). Employing the same formula splenic volume was reliably assessed in 47 patients with clinically evident splenomegaly. Quantitative assessment of splenic volume might be of value in assessing mild variations in splenic size, because splenomegaly is the most common manifestation of splenic involvement in many disorders.

Myelofibrosis‐associated massive splenomegaly: A cause of increased intra‐abdominal pressure, pulmonary hypertension, and positional dyspnea

“…In MMM, however, the spleen size and weight can reach enormous proportions, with the weight often exceeding 7 kg [17]. In our patient, the estimated weight of the spleen was greater than 5 kg as calculated by CT measurements [18]. The massively enlarged spleen in conjunction with the hepatomegaly caused the increased IAP.…”

Sexual Dimorphism in the Dimensions of Spleen in the Population of North-West Ethiopia – An Observational Radiographic Study

“…But, on average it is 2.5 cm thick, 7.5 cm wide and 12.5 cm long. [4] A sonographic study of adult spleen showed that spleen size decreased with increasing age. And, as it is reported from autopsy findings, the size of spleen was smaller in females than male study subjects.…”

“…Congestive heart failure with ascites and hepatosplenomegaly, lymphoid tissue and haematological malignancies, glycogen storage disorders, sarcoidosis and amyloidosis are other important causes of splenic involvement. [3][4][5] The splenic parenchyma consists of lymphatic follicles and reticuloendothelial cells, surrounding the arteries ('white pulp') and an interspersed network of vascular sinusoids ('red pulp'). [3] The ratio of white to red pulp increases with age due to accumulated antigenic exposure and stimulation.…”

“…[2] In the open 'slow flow' circulation, blood flows into a reticular fibrous framework of the red pulp and/or via the marginal zone of the lymphatic tissue before reaching the sinusoids. [4] These variable circulatory routes through the splenic pulp may explain the unique inhomogeneous early enhancement pattern of the spleen on computed tomography (CT) and magnetic resonance (MR) imaging. [1] Section: Anatomy Spleen is a reticulo-endothelial and lymphoid organ and sometimes works as haemopoietic organ.…”

Normal dalak ile splenomegalinin karşılaştırılması ve vücut kompozisyonu ile ilişkileri

“…Litertatürde dalak hacmi üzerine yapılmış çok sayıda ça-lışma mevcuttur (8,(12)(13)(14)(15). Bu durum dalak hacminin doğru tespit edilmesine ve normal sınırlarının belirlenmesine yönelik gerekliliği ortaya koymaktadır.…”