Determination of neuron-specific enolase in patients with midgut-type tumour treated with somatostatin analogues

Gut, Paweł; Czarnywojtek, Agata; Sawicka‐Gutaj, Nadia; Woliński, Kosma; Maciejewski, Adam; Komarnicki, Paweł; Ruchała, Marek

doi:10.5603/ep.a2021.0060

Cited by 5 publications

(8 citation statements)

References 14 publications

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“…On the other hand, in our study, the analysis of concentrations in patients with small intestine lesions did not show a correlation between the degree of malignancy and the values of the marker determined. The results of our study did not confirm literature reports in which the authors indicate statistical differences already between low and intermediate degree of malignancy and NSE in patients with small intestine lesions (22). NSE concentrations were not associated with gender or age.…”

Section: Discussioncontrasting

confidence: 99%

“…This group of patients was characterised by significantly higher concentrations of the marker in relation to patients without liver metastases. The results of our study confirmed previous reports on the influence of liver lesions on NSE concentrations ( 21 , 22 ). These results are difficult to relate to the study reporting no effect of the presence of liver metastases on NSE levels because the authors do not specify the site of metastasis and the group of patients without metastases included only three patients ( 16 ).…”

Section: Discussionsupporting

confidence: 92%

“…A significant result was the demonstration that regardless of the location of the primary lesion, disease progression was always signalled by statistically higher NSE concentrations. Similar observations regarding the relationship between NSE concentrations and clinical status are confirmed by data published by other authors ( 21 , 22 ).…”

Section: Discussionsupporting

confidence: 91%

“…To date, studies investigating the relationship between NSE concentrations and degree of malignancy have produced an exceptional variety of results. Authors report differences in NSE concentrations between grades or show similar results to our study, as well as report no association of marker concentrations with malignancy grade ( 16 , 21 , 22 , 23 ).…”

Section: Discussionsupporting

confidence: 91%

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Serum levels of neuron-specific enolase as a prognostic factor for disease progression in patients with GET/NEN in the pancreas and the small intestine

Fuksiewicz

Kowalska

Kolasinska-Cwikla

et al. 2022

Endocrine Connections

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The aim of this study was to assess the usefulness of NSE concentrations as a prognostic factor in patients with neuroendocrine neoplasms and in determining the relationship between NSE and clinicopathological features. Serum NSE levels were assayed in 179 NENs patients before treatment. It was found that NSE levels in patients with a primary pancreatic location were higher compared in patients with a small intestine lesion (p=0.015). It was found that in patients with only primary location in the pancreas, NSE levels were significantly higher in the group with histological grade G2 compared with the group with low grade G1 (P=0.047). Patients with initial liver involvement showed significantly higher NSE levels in patients with tumour location in the pancreas (P=0.009). Statistical analysis confirmed that higher NSE levels were associated with disease progression (p=0.001) in both the overall study group and in patients with tumours in the pancreas and small intestine. During treatment monitoring, an increase in median NSE concentrations was observed in patients with persistent progression with subsequent blood draws, and a decrease in NSE concentrations was observed in patients with disease stabilisation. We showed that NSE concentrations have prognostic value for progression free survival in addition to primary liver involvement. In conclusion, the most important results of the study include the demonstration of an association between NSE concentrations and clinical status, which confirms its usefulness in patient monitoring and as a potential predictive indicator for progression free survival in patients with NENs.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

See 2 more Smart Citations

Serum levels of neuron-specific enolase as a prognostic factor for disease progression in patients with GET/NEN in the pancreas and the small intestine

Fuksiewicz

Kowalska

Kolasinska-Cwikla

et al. 2022

Endocrine Connections

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“…NSE is a glycolytic enzyme present in neurons and neuroendocrine cells in the central and peripheral nervous system. Elevated concentrations of NSE in body fluids can be found not only in septic shock and post-traumatic states, but also in conditions associated with cell proliferation, such as neoplasms [ 66 , 67 ]. The latter property was hoped to be useful in detecting NETs, however, research shows that NSE is elevated in just 19% of G1NET and 54% of G2NET cases.…”

Section: Discussionmentioning

confidence: 99%

Circulating Neuroendocrine Tumor Biomarkers: Past, Present and Future

Komarnicki

Musiałkiewicz

Stańska

et al. 2022

JCM

Self Cite

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Neuroendocrine tumors are a heterogeneous group of neoplasms originating from the diffuse endocrine system. Depending on primary location and hormonal status, they range in terms of clinical presentation, prognosis and treatment. Functional tumors often develop symptoms indicating an excess of hormones produced by the neoplasm (exempli gratia insulinoma, glucagonoma and VIPoma) and can be diagnosed using monoanalytes. For non-functional tumors (inactive or producing insignificant amounts of hormones), universal biomarkers have not been established. The matter remains an important unmet need in the field of neuroendocrine tumors. Substances researched over the years, such as chromogranin A and neuron-specific enolase, lack the desired sensitivity and specificity. In recent years, the potential use of Circulating Tumor Cells or multianalytes such as a circulating microRNA and NETest have been widely discussed. They offer superior diagnostic parameters in comparison to traditional biomarkers and depict disease status in a more comprehensive way. Despite a lot of promise, no international standards have yet been developed regarding their routine use and clinical application. In this literature review, we describe the analytes used over the years and cover novel biomarkers that could find a use in the future. We discuss their pros and cons while showcasing recent advances in the field of neuroendocrine tumor biomarkers.

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Analysis of Influencing Factors of Serum Stress Index and Prognosis of HICH Patients by Different Anesthesia Methods Combined with Small Bone Window Microsurgery

Zhao

Shi

Chen

2022

Journal of Healthcare Engineering

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In order to investigate the effects of sevoflurane on the serum stress index level and prognosis of patients with hypertensive cerebral hemorrhage (HICH) during small bone window microsurgery, a total of 102 HICH patients are selected for analysis. MAP values in both groups decreased significantly at T1 and T2 ( P < 0.05 ), and the changes in MAP and HR indexes in the sevoflurane combined group were more stable than those in the control group. The time of postoperative awakening in the sevoflurane combined group decreases significantly than the control group ( P < 0.001 ). The levels of T-AOC and GSH-Px in both groups increase significantly after operation, and those in the sevoflurane combined group increase significantly than the control group ( P < 0.001 ). The levels of MDA and 8-OHDG in the sevoflurane combined group decrease significantly than the control group after operation ( P < 0.05 ). Spearman correlation coefficient analysis shows that the levels of T-AOC and GSH-Px are negatively correlated with the prognosis of HICH patients, while MDA and 8-OHDG are positively correlated with the prognosis of HICH patients ( P < 0.001 ). Sevoflurane interventional anesthesia has a high anesthetic effect in small bone window microsurgery, which has positive effects on controlling blood pressure of HICH patients, shortening postoperative recovery time and improving patients’ stress response and neurological function. This paper conducts an in-depth analysis of the prognosis of HICH patients, indicating that the prognosis of HICH patients is closely related to their serum stress indicators T-AOC, GSH-Px, MDA, and 8-OHDG, providing a new direction for follow-up clinical diagnosis and treatment of HICH patients and accurate prognosis assessment.

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Determination of neuron-specific enolase in patients with midgut-type tumour treated with somatostatin analogues

Cited by 5 publications

References 14 publications

Serum levels of neuron-specific enolase as a prognostic factor for disease progression in patients with GET/NEN in the pancreas and the small intestine

Serum levels of neuron-specific enolase as a prognostic factor for disease progression in patients with GET/NEN in the pancreas and the small intestine

Circulating Neuroendocrine Tumor Biomarkers: Past, Present and Future

Analysis of Influencing Factors of Serum Stress Index and Prognosis of HICH Patients by Different Anesthesia Methods Combined with Small Bone Window Microsurgery

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