Alternation of the melting temperature of irradiated mixed oxide (MOX) fuel in fast reactors with progress of burnup was determined in relation to the actinide fractions contained and of the oxygen-to-metal (O/M) ratio. Based on ideal solution models of UO 2 -PuO 2 and UO 2 -PuO 2 -Am 2 O 3 systems and on correlations obtained of the measured melting with O/M ratio and with burnup, an equation was derived expressing the estimated melting temperature T rev (K) as function of the factors mentioned above that affect the temperature:, where X 1 is the plutonium fraction (Pu/(Pu+U)), X 2 the americium fraction (Am/(Pu+U+Am)), X 3 the burnup (GWd/t), and X 4 the O/M ratio (−) (not exceeding 2.00). Toward advanced stage of burnup, the tendency of irradiated fuel melting temperature to lower with burnup progress presented a tendency to level off its rate of descent.