Determination of Isonicotinic Acid Hydrazide Using N-Bromosuccinimide

Selective determination of isoniazid using bentonite clay modified electrodes

“…It is also essential for pharmaceutical industries to determine the IZ level in their products for quality control purposes. Whereas the current methods like high performance liquid chromatography, spectrophotometry, volumetric titrimetry, chemiluminescence, capillary electrophoresis [3][4][5][6][7] require lengthy sample pretreatment procedures for the quantification of IZ, electrochemical methods offer simple and green routes to determine traces of IZ selectively. However, electrochemical oxidation of IZ at a bare glassy carbon (GC) electrode suffers from electrode fouling, sluggish electron transfer kinetics and large oxidation overpotential.…”

Capillary electrophoresis analysis of isoniazid using luminol‐periodate potassium chemiluminescence system

“…Thus, the determination of ISO concentration in biological fluids and pharmaceutical preparations is important for clinical pharmacology research and quality control of this drug. Various assay methods have been developed to detect ISO, including titration (3,4), high‐performance liquid chromatography (HPLC) using ultraviolet (UV) (5,6) and mass spectrometric (MS) detection (7–9), capillary electrophoresis (CE) using UV detection (10), electrochemistry (11–13), fluorimetry (14,15), flow injection chemiluminescence (CL) (16–19) and electrochemiluminescence (20,21). These methods often require sophisticated instrumentations or time‐consuming manipulations.…”

Ethyl Chloroformate as a Derivatizing Reagent for the Gas Chromatographic Determination of Isoniazid and Hydrazine in Pharmaceutical Preparations

“…10 Hydrazine (HZ) is a toxic substance and may be present in INH-based pharmaceuticals preparations as one of the decomposition products. 11 Various analytical techniques, such as titrimetry, 12,13 spectrophotometry, [14][15][16] spectrofluorometry, 17 atomic absorption, 18 chemiluminescence, 19 electroanalytical techniques, 20,21 kinetic determination, 22 flow injection, 23,24 thin layer chromatography, 25,26 capillary electrophoresis 27,28 and liquid chromatography [29][30][31][32] have been used for the quantitation of INH in pharmaceutical preparations and biological samples. Liquid chromatography with UV detection is carried out either by measuring the perse absorbance of INH at 263 nm or by precolumn derivatization with a suitable derivatizing reagent.…”