Determination of digoxin in serum samples using a flow-through fluorosensor based on a molecularly imprinted polymer

Instant formation of molecularly imprinted poly(ethylene-co-vinyl alcohol)/quantum dot composite nanoparticles and their use in one-pot urinalysis

“…Small molecules have already been widely explored, and protein-imprinted polymers have been presented for sensing biomarkers in biological fluid, particularly urine (Lee et al, 2008) and serum/plasma (Gonzalez et al, 2008;Hugon-Chapuis et al, 2008). These biological fluids may also contain some traceable drugs (Hugon-Chapuis et al, 2008) and metabolites (Lee et al, 2008).…”

The development of a MIP-optosensor for the detection of monoamine naphthalenes in drinking water

“…Furthermore, these materials can be employed in both aqueous and non-aqueous media and may be manufactured in several configurations. Thus, the use of MIP appears to be a very interesting alternative to obtain new powerful recognition materials that can be used in the development of optical chemical sensors (Suárez Rodríguez and Díaz García, 2001;Blanco López et al, 2004;Adhikari and Majumdar, 2004;Sánchez Barragán et al, 2005;Lakshmi et al, 2006;Breton et al, 2006;Paniagua Gonzalez et al, 2008). The basic approach consists of extracting the organic pollutants from the samples with a non-polar solid material and measuring their luminescence emission directly on the solid substrate.…”

Contribution to Automation for Determination of Drugs Based on Flow-Through Optosensors

“…The added economy and simplicity and relative flexibility have made it the officially recommended choice for determining the purity of many drugs in pharmaceutical Downloaded by [Uppsala universitetsbibliotek] at 23:25 06 October 2014 Table 1 Monoparameter FTOs with photometric detection Table 2 Multiparameter FTOs with photometric detection Table 3 Monoparameter FTOs with fluorimetric detection Table 4 Multiparameter FTOs with fluorimetric detection preparations. The intrinsic fluorescence of the analyte has been used for the determination of several compounds, such as naphazoline (64) or propanolol (65) using commercial solid supports, tetracyclines using a modified cyclodextrin based sensor (66), and digoxin by means of an MIP fluorosensor (67). Because there are a small number of compounds that exhibit native fluorescence, derivatization reactions have been employed to increase the number of applications.…”