Determination of diffusion coefficient for released nanoparticles from developed gelatin/chitosan bilayered buccal films

Barzoki, Zahra Mahdizadeh; Emam‐Djomeh, Zahra; Mortazavian, Elaheh; Rafiee-Tehrani, Niyousha; Behmadi, Homa; Rafiee-Tehrani, Morteza; Moosavi-Movahedi, Ali Akbar

doi:10.1016/j.ijbiomac.2018.01.215

Cited by 19 publications

(15 citation statements)

References 29 publications

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“…− ions in TPP [29]. As presented in Table 3, the polydispersity index (PDI) value for all prepared SGN-TC nanoparticles was found to be less than 0.5, which indicates a narrow size distribution [31].…”

Section: Effect Of the Formulation Factors On The Entrapment Efficienmentioning

confidence: 91%

“…where Y is the response; b 0 is the intercept; b 1 to b 23 are the regression coefficients; and X 1 , X 2 , and X 3 are the formulation factors [31].…”

Section: Optimization Of Formulation Variablesmentioning

confidence: 99%

“…The sample was allowed to dry and then stained with a uranyl acetate solution. After complete drying of the stain, the sample was examined by TEM (acceleration voltage, 100 kV) [31,41].…”

Section: Determination Of the Surface Morphology Of Sgn-tc Nanoparticlesmentioning

confidence: 99%

“…The preparation of SGN-TC nanoparticles was performed using the ionic gelation method. Mahdizadeh Barzoki et al used a Box-Behnken statistical design for optimization of insulin loaded thiolated chitosan nanoparticles [31]. According to the previous design, 17 formulations were prepared and evaluated for the results of particle size (Y 1 ), entrapment efficiency (Y 2 ), and drug release (Y 3 ).…”

Section: Optimization Of Formulation Factors Of Sgn Loaded Tc Nanoparmentioning

confidence: 99%

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Optimization of Thiolated Chitosan Nanoparticles for the Enhancement of in Vivo Hypoglycemic Efficacy of Sitagliptin in Streptozotocin-Induced Diabetic Rats

2020

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Sitagliptin (SGN) is an antidiabetic drug used for treatment of diabetes mellitus type II. The objectives of this study were to formulate SGN in form of thiolated chitosan (TC) nanoparticles to enhance the mucoadhesion properties of SGN to the gastrointestinal tract, prolong drug release, decrease side effects, and enhance patient compliance. Seventeen batches of SGN-TC nanoparticles were designed by Box-Behnken design and prepared using the ionic gelation method using tripolyphosphate (TPP) as crosslinking agent. The prepared formulations were evaluated for particle size, entrapment efficiency %, and in vitro drug release. Based on the results of optimization, three formulations (F1–F3) were prepared with different drug polymer ratios (1:1, 1:2, and 1:3). The mucoadhesion study and in vivo hypoglycemic activity of three formulations were evaluated in comparison to free SGN in streptozotocin (STZ)-induced diabetic rats. The seventeen SGN-TC nanoparticles showed small particle sizes, high entrapment efficiency, and prolonged drug release. The concentration of TC polymers had highest effect on these responses. The percentage of SGN–TC nanoparticles adhered to tissue was increased and the release was prolonged as the concentration of TC polymer increased (F3 > F2 > F1). The hypoglycemic effect of SGN-TC nanoparticles was significantly higher than resulted by free SGN. It was concluded that TC nanoparticles had the ability to enhance the mucoadhesion properties of SGN and prolong the drug release. SGN-TC nanoparticles significantly reduced plasma glucose levels compared to free SGN in STZ-induced diabetic rats.

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Section: Effect Of the Formulation Factors On The Entrapment Efficienmentioning

confidence: 91%

“…where Y is the response; b 0 is the intercept; b 1 to b 23 are the regression coefficients; and X 1 , X 2 , and X 3 are the formulation factors [31].…”

Section: Optimization Of Formulation Variablesmentioning

confidence: 99%

“…The sample was allowed to dry and then stained with a uranyl acetate solution. After complete drying of the stain, the sample was examined by TEM (acceleration voltage, 100 kV) [31,41].…”

Section: Determination Of the Surface Morphology Of Sgn-tc Nanoparticlesmentioning

confidence: 99%

Section: Optimization Of Formulation Factors Of Sgn Loaded Tc Nanoparmentioning

confidence: 99%

See 2 more Smart Citations

Optimization of Thiolated Chitosan Nanoparticles for the Enhancement of in Vivo Hypoglycemic Efficacy of Sitagliptin in Streptozotocin-Induced Diabetic Rats

2020

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“…Nanoparticulate dosage forms differ from conventional dosage forms by loading the drug or active compound into nanoparticles prior to dispersion in a formulation base. They have been incorporated into various dosage forms for sublingual and buccal drug delivery, including gels (Marques et al, 2017), sprays (Baltzley et al, 2018), tablets (Gavin et al, 2015; El-Nahas et al, 2017), films (Giovino et al, 2013; Mortazavian et al, 2014; Al-Dhubiab et al, 2016; Masek et al, 2017; Castro et al, 2018a; Mahdizadeh Barzoki et al, 2018; Al-Nemrawi et al, 2019), and patches (Mahdizadeh Barzoki et al, 2016). These nanoparticulate formulations have been shown to: (i) improve drug permeability across the epithelium; (ii) modify drug release kinetics (e.g., controlled release or sustained release); (iii) provide solubilization (i.e., to deliver compounds which have physicochemical properties that strongly limit their aqueous solubility); and/or (iv) protect compounds that are sensitive to degradation (e.g., peptides) (Morales and Brayden, 2017; Hua et al, 2018).…”

Section: Nanoparticulate Drug Delivery Approachesmentioning

confidence: 99%

Advances in Nanoparticulate Drug Delivery Approaches for Sublingual and Buccal Administration

Hua¹

2019

Front. Pharmacol.

119

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The sublingual and buccal routes of administration have significant advantages for both local and systemic drug delivery. They have shown to be an effective alternative to the traditional oral route, especially when fast onset of action is required. Drugs can be rapidly and directly absorbed into the systemic circulation via venous drainage to the superior vena cava. Therefore, they are useful for drugs that undergo high hepatic clearance or degradation in the gastrointestinal tract, and for patients that have swallowing difficulties. Drugs administered via the sublingual and buccal routes are traditionally formulated as solid dosage forms (e.g., tablets, wafers, films, and patches), liquid dosage forms (e.g., sprays and drops), and semi-solid dosage forms (e.g., gels). Conventional dosage forms are commonly affected by physiological factors, which can reduce the contact of the formulation with the mucosa and lead to unpredictable drug absorption. There have been a number of advances in formulation development to improve the retention and absorption of drugs in the buccal and sublingual regions. This review will focus on the physiological aspects that influence buccal and sublingual drug delivery and the advances in nanoparticulate drug delivery approaches for sublingual and buccal administration. The clinical development pipeline with formulations approved and in clinical trials will also be addressed.

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Recent progress in polymeric non-invasive insulin delivery

Sabbagh

Muhamad

Niazmand³

et al. 2022

International Journal of Biological Macromolecules

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Determination of diffusion coefficient for released nanoparticles from developed gelatin/chitosan bilayered buccal films

Cited by 19 publications

References 29 publications

Optimization of Thiolated Chitosan Nanoparticles for the Enhancement of in Vivo Hypoglycemic Efficacy of Sitagliptin in Streptozotocin-Induced Diabetic Rats

Optimization of Thiolated Chitosan Nanoparticles for the Enhancement of in Vivo Hypoglycemic Efficacy of Sitagliptin in Streptozotocin-Induced Diabetic Rats

Advances in Nanoparticulate Drug Delivery Approaches for Sublingual and Buccal Administration

Recent progress in polymeric non-invasive insulin delivery

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