Determination of ciprofloxacin, enrofloxacin and flumequine in pig plasma samples by capillary isotachophoresis–capillary zone electrophoresis

Hernández, Margarita; Aguilar, Carme; Borrull, Francesc; Calull, Marta

doi:10.1016/s1570-0232(02)00071-5

Cited by 112 publications

(63 citation statements)

References 33 publications

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“…The CPFX residues in consumed animal tissues raise potential risks for development of drug-resistance and chronic adverse effects in public health (6). The maximum residue limits (MRLs) of CPFX in food stuffs of animal origin were established by the European Union (7).…”

Section: Introductionmentioning

confidence: 99%

Influence of hapten density on immunogenicity for anti-ciprofloxacin antibody production in mice

Xing

Jiang

et al. 2012

Biosci Trends

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Section: Introductionmentioning

confidence: 99%

Influence of hapten density on immunogenicity for anti-ciprofloxacin antibody production in mice

Xing

Jiang

et al. 2012

Biosci Trends

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“…, respectively, for the same fluoroquinolones. The detection limits of the proposed method were lower than those for LC [9] and CE [15,16,18,19], and higher or close to those for LC-MS-MS [12] or SPE-LC-MS-MS [20]. The obtained detection limits of the fluoroquinolones studied permit the detection in milk samples at the targeted MLRs.…”

Section: Validation Resultsmentioning

confidence: 72%

“…Analysis of antibiotics in biological samples by CE has been reviewed in 2003 [14]. To increase the selectivity and sensitivity of CE, solid phase extraction (SPE) has been combined with CE for the determination of fluoroquinolones in plasma samples with detection limits of 2.2 mg L -1 for ciprofloxacin and 1.6 mg L -1 for flumequine [15], ciprofloxacin and its impurities with the detection limit of 1 mg L -1 [16], flumequine and oxolinic acid in chicken tissues with detection and quantification limits of 10 and 30 lg kg -1 for flumequine [17], ciprofloxacin, enrofloxacin and flumequine in pig plasma samples with the detection limits of 70, 85 and 50 lg L -1 , respectively [18], and quinolones residues in porcine tissue with the detection limit of 40 lg kg -1 for ciprofloxacin and 35 lg kg -1 for enrofloxacin [19]. However there are only few reports of SPE-CE for the detection of quinolone residues in milk samples [20].…”

Section: Introductionmentioning

confidence: 97%

Effective Separation and Simultaneous Determination of Four Fluoroquinolones in Milk by CE with SPE

Sun

Zhao

2008

Chroma

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A simple and sensitive capillary electrophoresis method with solid phase extraction was developed for the determination of sarafloxacin, ciprofloxacin, enrofloxacin and flumequine in milk. Solid-phase extraction with Oasis HLB cartridge column was used for the isolation of four fluoroquinolones in raw milk from a farm and fresh milk sample. Separation conditions of CE, including running buffer, voltage and temperature, were investigated and optimized. Baseline separation was achieved for the four fluoroquinolones under the developed conditions. Correlation coefficients greater than 0.9998 were obtained for all fluoroquinolones with a dynamic range from 1 up to 100 mg L -1. The intra-day precision was less than 5%, and the inter-day precision was less than 6%. The method recoveries of four fluoroquinolones were in the range of 70.9-90.6%. The detection limits for sarafloxacin, ciprofloxacin, enrofloxacin and flumequine was 19.8, 15.2, 13.3 and 15.9 lg kg -1

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“…The HPTLC method has been developed for the determination and the purity control of CF in coated tablets [14,15]. Other different methods were reported such as spectrophotometry [16][17][18][19][20][21][22], fluorimetry [22][23][24], capillary electrophoresis [25][26][27][28][29][30][31][32] and immunoassay [33,34]. Both spectrophotometric [35][36][37][38] and chemiluminescent [39,40] detection were proposed as automatic spectroscopy procedures.…”

Section: Introductionmentioning

confidence: 99%

Preconcentration and Determination of Ciprofloxacin with Solid-phase Microextraction and Silica-coated Magnetic Nanoparticles Modified with Salicylic Acid by UV-Vis Spectrophotometry

Neshin¹,

Ebrahimi²

2018

Eurasian J Anal Chem

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In the present age, the pharmaceutical application continues to increase and this results in the environmental pollution. As a result, pharmaceutical control is a common technique in many labs. This project is on the improvement of the procedure to determine a small amount of ciprofloxacin (CF) in bio-environmental sample. Regarding the fact that each method requires preliminary measures to preconcentrate and prepare analyte prior to measurement and recognition. In recent study, preconcentration of samples containing CF (as antibiotic) based on solid-phase microextraction method using silica-coated magnetic nanoparticles modified with salicylic acid (SA) was proposed which acted as sorbent. In addition, UV-Vis spectrophotometry was carried out to determine the amount of CF. The wavelength of maximum absorption (λmax) for this drug was 275 nm. Also, the optimum conditions of various parameters such as pH of solution, amount of magnetic nanoparticles, time, the effect of stirring speed on the extraction and desorption, the rate of centrifugation, the volume of aqueous and organic-phases, temperature and salt effect were investigated. The dynamic range was obtained between 0.05-0.15 mg L -1 , LOD and RSD (%) were 0.002 mg L -1 and 1.878 respectively. Results showed using this procedure increased the concentration factor to 68.36. Relative recovery was achieved by spike method.

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Determination of ciprofloxacin, enrofloxacin and flumequine in pig plasma samples by capillary isotachophoresis–capillary zone electrophoresis

Cited by 112 publications

References 33 publications

Influence of hapten density on immunogenicity for anti-ciprofloxacin antibody production in mice

Influence of hapten density on immunogenicity for anti-ciprofloxacin antibody production in mice

Effective Separation and Simultaneous Determination of Four Fluoroquinolones in Milk by CE with SPE

Preconcentration and Determination of Ciprofloxacin with Solid-phase Microextraction and Silica-coated Magnetic Nanoparticles Modified with Salicylic Acid by UV-Vis Spectrophotometry

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