Determination of ceruloplasmin, some other acute phase proteins, and biochemical parameters in cows with endometritis

Kaya, Semra; Merhan, Oğuz; Kaçar, Cihan; Çolak, Abdürrahim; Bozukluhan, Kadir

doi:10.14202/vetworld.2016.1056-1062

Cited by 38 publications

(31 citation statements)

References 35 publications

(48 reference statements)

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“…In research aimed at improving animal health and welfare, ceruloplasmin might be useful (44). Previous studies have reported Cp to be a significant source of data in determining mastitis (3), subclinical mastitis (43), and endometritis (25) in cows. In a prior study on the influence of orchiectomy and dehorning on serum APP levels, sera samples were drawn from seven goats before and after the procedure.…”

Section: Resultsmentioning

confidence: 99%

Effects of selected nonsteroidal anti-inflammatory drugs on acute-phase protein levels after dehorning in Holstein heifers

Erdoğan¹,

Akin²,

Ural³

et al. 2019

Medycyna Weterynaryjna

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The purpose of this study was to evaluate the effects of ketoprofen (KTP), flunixin meglumine (FLM), and meloxicam (MLX) administration on acute-phase proteins after dehorning in Holstein heifers. A total of 21 Holstein heifers were enrolled into three groups of equal size (n=7) and administered ketoprofen, flunixin meglumine, or meloxicam, at doses of 2.2 mg/kg, 1.1 mg/kg, and 1 mg/kg body weight, respectively. Serum amyloid A, haptoglobin, and ceruloplasmin levels were determined before the administration of the three drugs (0 hrs) and at 6, 12, 24, 48, and 96 hours post-administration. The mean values (±SD) obtained revealed no significant alteration in APP levels at 0 hrs in any of the three groups. Time-dependent alterations, however, were significant in all groups. Group-time interactions were significant (P < 0.001) for ceruloplasmin concentrations, whereas results for serum amyloid A and haptoglobin levels were deemed non-significant. Inter-group interaction revealed no significant findings regarding serum amyloid A and ceruloplasmin levels, but haptoglobin levels showed a significant difference between the KTP and FLM groups at 48 hrs. It may therefore be reasonably suggested that KTP, FLM, and MLX could all be administered to effect slight changes in acute phase proteins.

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Section: Resultsmentioning

confidence: 99%

Effects of selected nonsteroidal anti-inflammatory drugs on acute-phase protein levels after dehorning in Holstein heifers

Erdoğan¹,

Akin²,

Ural³

et al. 2019

Medycyna Weterynaryjna

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“…Haptoglobin has been reported to be present in very low concentrations (<0.1 mg/mL) in healthy animals. But its concentrations increase and remain high in many bacterial, viral, parasitic and inflammatory diseases as long as the stimulus persists [7,[25][26][27][28] . It is a nonspecific marker of tissue damage, and suggested to be used to determine prognosis and severity of the diseases.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to these, all the infected sheep fully recovered and no cases of death were observed in the study, supporting to the good prognostic value of haptoglobin. Ceruloplasmin is considered as an indicator of the presence of infection [27,30,31] . It protects the cells against oxidative damage by reducing the effects of oxygen radicals, as well as increasing the phagocytic and antimicrobial efficiency of immune system cells [32] .…”

Section: Discussionmentioning

confidence: 99%

“…Increased in haptoglobin and ceruloplasmin levels determined in the study were presumably due to increased activity in phagocytic cells and/or tissue damage and inflammation reported in poxvirus infection [4,14] . Albumin, a negative APP, is a indicator of liver function and, its blood concentrations decrease in case of anorexia, liver disorders and intestinal malabsorptions [27,33] . Furthermore, its concentration has been shown to decrease in tissue damage and inflammatory conditions, in association with Determination of Some Acute Phase ... increased albumin catabolism [9,11] .…”

Section: Discussionmentioning

confidence: 99%

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Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi

Bozukluhan¹,

Merhan²,

Gokce³

et al. 2018

Kafkas Univ Vet Fak Derg

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The aim of the present study was to determine oxidative stress and acute phase response in naturally infected sheep with poxvirus. For this purpose, 20 poxvirus infected and 10 clinically healthy sheep were used in the study. In these animals, alkaline phosphatase (ALP), aspartate aminotransferase (AST) activity, haptoglobin, ceruloplasmin, urea, creatinine, albumin, iron (Fe), malondialdehyde (MDA) and reduced glutathione (GSH) concentrations were determined. The present study determined that the concentrations of haptoglobin, ceruloplasmin, urea, creatinine, MDA and ALP, AST activity were significantly increased, and albumin, Fe and GSH concentrations were significantly decreased in the sheeppox virus infected group compared to the control group. Results of this study indicated that oxidative stress and acute phase response develop in sheep infected with poxvirus. Keywords: Acute phase proteins, Biochemical parameters, Sheeppox Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi ÖzÇalışma poksvirüs ile doğal enfekte koyunlarda, oksidatif stres ve akut faz cevabı belirlemek amacıyla yapıldı. Çalışmada 20 adet çiçek hastalığı ile enfekte ve 10 adet klinik olarak sağlıklı koyun kullanıldı. Hayvanlarda alkalen fosfataz (ALP), aspartat aminotransferaz (AST) aktivitesi, haptoglobin, seruloplazmin, üre, kreatinin, albümin, demir (Fe), malondialdehit (MDA) ve redükte glutatyon (GSH) konsantrasyonları belirlendi. Çalışmada, poksvirus ile enfekte koyunlar ile kontrol grubundaki hayvanlar karşılaştırıldığında haptoglobin, seruloplazmin, üre, kreatinin, MDA değerleri ile ALP ve AST aktivitelerinin yükseldiği, albümin, Fe ve GSH konsantrasyonunun ise kontrol grubuna göre düştüğü belirlendi. Bu çalışmada poksvirus ile enfekte koyunlarda akut faz yanıtın oluştuğu ve oksidatif stresin geliştiği kanısına varıldı.

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“…Increased plasma malondialdehyde concentration which is a thiobarbituric acid reactive species, indicate oxidative status . Cows with endometritis had higher ceruloplasmin levels in plasma as positive APP compared with healthy cows (Kaya et al, 2016). During inflammation, copper binding ceruloplasmin mediated formation of reactive oxygen species and may promote oxidative pathology (Shukla et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Consequences of dry period length and dietary energy source on physiological health variables in dairy cows and calves

Mayasari¹

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During the transition period, dairy cows experience a negative energy balance (NEB) caused by the high energy requirement for milk yield, while feed intake is limited. Severity of the NEB has been associated with an increased incidence of metabolic disorders and infectious diseases, inflammation, immunosuppression and oxidative stress. It is known that shortening or omitting the dry period or feeding a glucogenic ration improves the energy balance (EB) in dairy cows in early lactation. It can be expected that an improvement of the EB due to shortening or omitting the dry period results in reduced inflammation, immunosuppression and less oxidative stress in dairy cows in early lactation. The first objective of this thesis was to study the effects of dry period length and dietary energy source on immune competence, inflammatory biomarkers and oxidative stress in dairy cows over 2 subsequent lactations. The second objective was to study the consequences of maternal dry period length on colostrum immunoglobulin content and immune competence of calves in the first 12 weeks of life. In the current study, 167 cows were assigned to 3 dry period lengths (0, 30, or 60 d) and 2 early lactation rations (glucogenic or lipogenic). Cows were planned to have the same dry period length and ration over 2 subsequent lactations. Omitting the dry period reduced plasma bilirubin levels compared with a conventional dry period, which is line with the better EB in cows with a 0-d dry period. Effects of dry period length on inflammatory biomarkers, oxidative stress variables and natural antibodies (NAb) titers were, however, less consistent. Omitting the dry period increased not only negative acute phase proteins (APP) in plasma, but also positive APP, oxidative stress variables in plasma, and NAb in milk. Shortening the dry period to 30-d did not influence inflammatory biomarkers and oxidative stress compared with a conventional dry period of 60-d. Occurrence of clinical health problems did not differ between cows with different dry period lengths. In the current study, changes in positive APP and oxidative stress variables in plasma and NAb in milk could be explained by the occurrence of clinical health problems related to inflammation (clinical mastitis, fever, metritis and retained placenta), rather than a better EB due to a shorter or no dry period. Moreover, a higher titer of IgG binding lipopolysaccharide in plasma was associated with decreased odds of high somatic cell count and occurrence of clinical mastitis. In the first lactation after implementation of dry period length and dietary treatments, feeding a glucogenic ration in early lactation increased NAb titers in milk compared with a lipogenic ration, which could be explained partly by a better EB. In the second lactation after implementation of dry period length and dietary treatments, feeding a lipogenic ration in early lactation increased cholesterol levels in plasma compared with a glucogenic ration, which could be related to the high fat content in this ration. Cows with...

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Determination of ceruloplasmin, some other acute phase proteins, and biochemical parameters in cows with endometritis

Cited by 38 publications

References 35 publications

Effects of selected nonsteroidal anti-inflammatory drugs on acute-phase protein levels after dehorning in Holstein heifers

Effects of selected nonsteroidal anti-inflammatory drugs on acute-phase protein levels after dehorning in Holstein heifers

Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi

Consequences of dry period length and dietary energy source on physiological health variables in dairy cows and calves

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