Determination of Carboxylic Acids Present as Esters in Plasticizers and Polymers by Transesterification and Gas Chromatography

Jankowski, Stanley J.; Garner, Patrick.

doi:10.1021/ac60232a020

Cited by 24 publications

(5 citation statements)

References 14 publications

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“…The major components were identified as Diisooctyl phthalate (96.903 %), 2-methyltetracosane (1.094 %), zinc bis (dipentyldithiocarbamate) (0.653 %), Acetamide,2,2'-[(2,2-dimethyl-1,3-propanediol] (0.496 %), Hexadecanoic acid, 2-bromo-(0.296 %) and others with less amount. The literature review found that some of the above compounds have antioxidant and antimicrobial properties [31][32][33][34][35][36][37]. Literature also found that hexadecanoic acid, 2-bromo-is used as a PPARδ agonist, inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation, and promote glucose uptake in rat cardiac cells and the insulin-sensitive murine fibroblast line A31-IS [36,37].…”

Section: C16h31bro2mentioning

confidence: 99%

Phytochemical Screening, GC-MS Analysis, and Evaluation of Antioxidants, Cytotoxicity, Analgesic, and Anti-Diarrheal Activity of the Extracts of the Leaves of Syzygium reticulatum Wight Walp

Das,

Sarkar,

Paul

et al. 2024

Trends Sci

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Syzygium genus is extensively used in managing different diseases such as antimicrobial, anti-diarrheal, antidiabetic, analgesic, anti-inflammatory, antioxidant, and anticancer activities. The present study aims to investigate phytochemicals by screening tests and GC-MS analysis and evaluate the antioxidants, cytotoxicity, analgesic, and anti-diarrheal activity of the extracts of the leaves of Syzygium reticulatum. The leaves of the S. reticulatum were extracted with hexane and methanol by the maceration process successively, denoted as SRH and SRM. The extract’s phytochemical analyses found flavonoids, alkaloids, saponins, tannins, glycosides, and carbohydrates. The GC-MS analysis of the methanol extract identified 8 compounds. The major components were identified as Diisooctyl phthalate (96.903 %), 2-methyltetracosane (1.094 %), and others with fewer amounts. The result of the antioxidant study of the extracts as total phenolic content of SRH 8.92 ± 0.62 and SRM 340.107 ± 11.11 mg/g, respectively, total flavonoids content of SRH 7.85 ± 0.71 and SRM 105.16 ± 0.93 mg/g, IC50 values of the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay of SRM was 14.67 µg/mL, SRH was 41.26 µg/mL and ascorbic acid 14.08 µg/mL; the total antioxidant capacity of SRH was 21.33 ± 2.52 mg/g, whereas SRM was 353.71 ± 4.59 mg/g. The results of these studies suggest that methanol extract has a more potent antioxidant capacity than hexane extract. The methanol extract also exhibited higher toxicity (LC50 value 49.99 µg/mL) compared to hexane extract (LC50 value 370.348 µg/mL), as revealed by the Brine shrimp nauplii cytotoxic study. An analgesic study of the methanol extract found that a lower dose (250 mg/kg) has more significant analgesic activity than the higher dose and standard drug aspirin. At 90 min, the hot plate’s highest percentage of latency elongation was 110.32, while the acetic acid-induced writhing inhibition was 63.04 %. At a dose of 500 mg/kg, the methanol extract also shown good efficacy in mice suffering from castor oil and magnesium sulfate-induced diarrhea. The findings from the study of the leaves of the S. reticulatum exhibited that methanol extracts have significant antioxidant, cytotoxic, analgesic, and anti-diarrheal activity. HIGHLIGHTS The extract’s phytochemical analyses found flavonoids, alkaloids, saponins, tannins, glycosides, and carbohydrates The GC-MS analysis of the methanol extract identified 8 compounds. The major components were identified as Diisooctyl phthalate (96.903 %), 2-methyltetracosane (1.094 %) The antioxidant and cytotoxicity studies suggest that methanol extract has a more potent antioxidant and cytotoxic capacity than hexane extract The findings from in-vivo study of the leaves of the reticulatum also exhibited that methanol extracts have significant analgesic, and anti-diarrheal activity GRAPHICAL ABSTRACT

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Section: C16h31bro2mentioning

confidence: 99%

Phytochemical Screening, GC-MS Analysis, and Evaluation of Antioxidants, Cytotoxicity, Analgesic, and Anti-Diarrheal Activity of the Extracts of the Leaves of Syzygium reticulatum Wight Walp

Das,

Sarkar,

Paul

et al. 2024

Trends Sci

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show abstract

“…The method is applicable to 0.05-to 0.2-gram samples and has a relative error in accuracy of 10%. Similar techniques for identifying carboxylic acids in plasticizers, in polyesters fibers, and in alkyd coating resins have been described (3)(4)(5). In these techniques, isophthalic, terephthalic, adipic, and sebacic acids have been recovered and converted to methyl esters from their products via transesterification with sodium methoxide and separated by gas chromatography.…”

Section: Received For Reviewmentioning

confidence: 99%

Selection of optimum position for measuring widths of chromatographic peaks with minimum error in area

Ball¹,

Harris²,

Habgood³

1968

Anal. Chem.

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“…Jankowski and Garner (68) determined the carboxylic acids present as esters in plasticizers and polymers by transesterification and gas chromatographic separation. Sodium methoxide in methanol and methyl acetate as reagent gave quantitative yield of the esters which were extracted and chromatographed with diphenyl ether as internal standard.…”

Section: Specific Constituentsmentioning

confidence: 99%

Coatings

Swann¹,

Adams²,

Esposito³

1967

Anal. Chem.

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Determination of Carboxylic Acids Present as Esters in Plasticizers and Polymers by Transesterification and Gas Chromatography

Cited by 24 publications

References 14 publications

Phytochemical Screening, GC-MS Analysis, and Evaluation of Antioxidants, Cytotoxicity, Analgesic, and Anti-Diarrheal Activity of the Extracts of the Leaves of Syzygium reticulatum Wight Walp

Phytochemical Screening, GC-MS Analysis, and Evaluation of Antioxidants, Cytotoxicity, Analgesic, and Anti-Diarrheal Activity of the Extracts of the Leaves of Syzygium reticulatum Wight Walp

Selection of optimum position for measuring widths of chromatographic peaks with minimum error in area

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