Determination of antibiotic compounds in water by on-line SPE-LC/MSD

Choi, Keun-Joo; Sang-Goo, Kim; Kim, Changwon; Kim, Seung Hyun

doi:10.1016/j.chemosphere.2006.07.037

Cited by 123 publications

(55 citation statements)

References 15 publications

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“…The limits of detection (LODs) were almost the same for off-line SPE as for on-line SPE. SPE with LC-MS through the on-line connection has been used for the determination of SAs and TCs in wastewaters [48]. Coupling of SPE procedures on-line with LC provided several advantages, such as reduction of the number of sample handling steps required, elimination the target loss by keeping in the cartridge from drying which results in recovery improvement and saving of the analytical time and minimization of the consumption of organic solvents for each analysis.…”

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

“…In many multiresidue studies, simatone was chosen for MS detection as IS because it is eluted within the same chromatographic time frame as analytes, responded well in ESI + mode and had no noticeable matrix effects [4,21,32,33,48]. 13 C-phenacetin was used very often in studies where antibiotics were analyzed together with other pharmaceuticals [1,24,27,38,40,41,61].…”

Section: Internal Standardmentioning

confidence: 99%

“…Some authors employed HPLC with UV detection. The detection was performed at 360 nm [32,48] or at 280 nm [11]. 280 nm was used for the detection in multiresidue study in which other veterinary antibiotics were determined, although UV detection was not as sensitive and specific as MS detection.…”

Section: Tetracycline Antibioticsmentioning

confidence: 99%

See 2 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

314

170

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a b s t r a c tThe widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development of antimicrobial resistance among microorganisms. This article presents an overview of analytical methodologies for the determination of quinolone (Qs) and fluoroquinolone (FQs), macrolide (MLs), tetracycline (TCs), sulfonamide (SAs) antibiotics and trimethoprim (TMP) in different environmental waters. The analysis of these antibiotics has usually been carried out by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) and to a lesser extent by ultraviolet (UV) or fluorescence detection (FD). A very important step before LC analysis is sample preparation and extraction leading to elimination of interferences and prevention of matrix effect and preconcentration of target analytes.

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Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

Section: Internal Standardmentioning

confidence: 99%

See 1 more Smart Citation

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

314

170

View full text Add to dashboard Cite

show abstract

“…Some studies, however, point toward developing methods with the SPE-LC-MS/MS system, which allows reduction in the sample amount, lower preparation time, and consequently, increase in productivity, in addition to less sample manipulation, decreasing contamination chances [128][129][130][131][132]. The SPE-online system has also been used for the determination of pesticides, hormones, explosives, pharmaceuticals, and personal care products [133][134][135][136][137].…”

Section: Sample Preparation Techniquesmentioning

confidence: 99%

Veterinary Antibiotics in the Environment

Botelho¹,

Monteiro²,

LuizTornisielo³

2015

Emerging Pollutants in the Environment - Current and Further Implications

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In recent years, pharmaceutical pollution in the environment has been a great concern due to the potential effects on the human and animal health. Some of the most used classes such as antibiotics, which are used to prevent and treat bacterial infections and promote the growth of livestock, deserve to be highlighted since their intensive use has contaminated environmental matrices such as soil, water, sediment, plants, and animals with effects on the biota. To better understand the potential ecological risk of antibiotics in environments and to develop management strategies for these substances searching to reach the reduction of these compounds in aquatic systems, one of the most important steps is to determine the environmental concentrations of these compounds in the environments through analytical methods and evaluate their effects on the biota. The goal of this chapter is contribute with information about the effects of these compounds on the biota as well as its environmental behavior and bacterial resistance in additional to the main techniques for samples preparation and quantitative and confirmatory methods for its determination in the environment.

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“…Nos seres humanos são usados para tratamento de doenças enquanto que nos animais, além das doenças eles são usados para estimular o seu crescimento e produção (CHOI et al, 2006). Estudos realizados na Europa, Coreia, Austrália, Estados Unidos e no Brasil demostram a crescente preocupação com os impactos desses fármacos no ambiente, especialmente por não existir um parâmetro que estabeleça os limites aceitáveis dessas substancias no ambiente aquático (OSENGA, 2004;COSTANZO, MURBY e BATES, 2005;HERNÁNDEZ et al, 2007;CHOI et al, 2007;FILHO et al, 2007). Foi observado em diversos estudos que os resíduos fármacos tem um impacto negativo no meio aquático (OSENGA, 2004;FILHO et al, 2007).…”

Section: Introductionunclassified

O uso indiscriminado de antibióticos e os impactos nos ambientes aquáticos

Carvalho¹,

Mascoli²,

Américo-Pinheiro³

2016

ANAP

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RESUMOO uso indiscriminado de antibióticos na medicina humana e veterinária tem causado a contaminação frequente dos ambientes aquáticos. O objetivo desse trabalho foi realizar uma revisão de literatura identificando as possíveis rotas dos antibióticos nos ambientes aquáticos e determinar os possíveis impactos negativos desses fármacos nos ecossistemas aquáticos. A metodologia utilizada foi à busca de artigos científicos, dissertações e livros nos sites Google Acadêmico e Science Direct. Foram identificados diversos impactos negativos relacionados a contaminação do meio por antibióticos como o surgimento de bactérias resistentes, toxicidade para algas, macrófitas, microcrustáceos e peixes. A venda controlada de antibióticos surge como uma alternativa imediata que pode reduzir esses impactos. No entanto, são necessários estudos de monitoramento dessas substâncias nos ambientes aquáticos, ensaios de toxicidade que identifiquem seus possíveis efeitos na biota aquática, além da busca por sistemas de tratamento de efluentes domésticos e hospitalares que visem a eliminação desses fármacos. PALAVRAS-CHAVE:Fármacos. Bactérias resistentes. Contaminação. AbstractIndiscriminate use of antibiotics in human and veterinary medicine has caused frequent contamination of aquatic environments. The aim of this study was to conduct a literature review identifying the possible routes of antibiotics in aquatic environments and to determine the possible negative effects of these pharmaceuticals on aquatic ecosystems. The methodology used was the search for scientific articles, dissertations and books in Google Scholar and Science Direct website. Negative impacts were identified related to contamination of the antibiotic as the emergence of resistant bacteria, toxicity to algae, macrophytes, microcrustaceans and fishes. The controlled sale of antibiotics emerges as an immediate alternative that can reduce these impacts. However, studies are needed to monitor these substances in aquatic environments, toxicity tests to identify their possible effects on aquatic biota, as well as search for treatment of domestic and hospital waste systems that aim to eliminate these drugs.KEY WORDS: Pharmaceuticals. Resistant bacteria. Contamination. ResumenEl uso indiscriminado de antibióticos en la medicina humana y veterinaria ha causado la contaminación frecuente de los medios acuáticos. El objetivo de este estudio fue realizar una revisión de la literatura identificar las posibles rutas de antibióticos en los ambientes acuáticos y para determinar los posibles efectos negativos de estos fármacos en los ecosistemas acuáticos. La metodología utilizada fue la búsqueda de artículos científicos, tesis y libros en Google Scholar y Science Direct. Se identificaron muchos impactos negativos relacionados con la contaminación del antibiótico como la aparición de bacterias resistentes, toxicidad para las algas, macrófitos, microcrustaceos y peces. La venta controlada de antibióticos surge como una alternativa inmediata que puede reducir estos impactos. Sin embar...

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Determination of antibiotic compounds in water by on-line SPE-LC/MSD

Cited by 123 publications

References 15 publications

An overview of analytical methodologies for the determination of antibiotics in environmental waters

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Veterinary Antibiotics in the Environment

O uso indiscriminado de antibióticos e os impactos nos ambientes aquáticos

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