Determination of acetazolamide in biological fluids by high-performance liquid chromatography

Effectiveness of Generic Acetazolamide

“…Serum levels of acetazo¬ lamide were determined by high-pressure liquid chromatography analysis as de¬ scribed by Gal and co-workers. 1 Six pharmacies in the Denver area were contacted to establish comparative costs of the acetazolamide products. Brand-name acetazolamide was obtained from the Uni¬ versity of Colorado Hospital pharmacy, Denver, as scored 250-mg tablets.…”

Effectiveness of Generic Acetazolamide

“…Serum levels of acetazo¬ lamide were determined by high-pressure liquid chromatography analysis as de¬ scribed by Gal and co-workers. 1 Six pharmacies in the Denver area were contacted to establish comparative costs of the acetazolamide products. Brand-name acetazolamide was obtained from the Uni¬ versity of Colorado Hospital pharmacy, Denver, as scored 250-mg tablets.…”

Tb -4'carboxybenzo-18crown-6-ether Photo Probe or the Assessment of Nalbuphin HCl in Serum and Pharmaceutical Formulations

“…Luminescent photo probes lanthanide complexes have more advantages over the present ones; photo probe has high stability and durability. The photo probe can provide constant signal response for 2 years which is 24-fold better stability compared to the life time warranted for the chromatographic and colorimetric methods [6][7][8][9][10][11][12][13][14]. Photo probe is stable over all measurements which prevent the source of error in the measurement process and it gives a low standard deviation values.…”

Validated Stability indicating Spectrophotometric Method for the Determination of Acetazolamide in Dosage Forms through Complex Formation with Palladium (II)

“…It acts on the central nervous system to retard the abnormal, paroxysmal, and excessive discharge from CNS neurons (1). Various methods were reported for its determination either per se or in pharmaceutical preparations and biological fluids including: spectrophotometry (2)(3)(4)(5)(6), HNMR (4), electrochemical methods (7,8), and HPLC (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The British Pharmacopoeia (BP) (28) recommended potentiometric determination of ACM in dimethylformamide using ethanolic solution of sodium hydroxide as a titrant, while the United States Pharmacopoeia (USP) method (29) recommended a spectrophotometric measurement of the acidic solution of the pharmaceutical preparation at 265 nm.…”

Effectiveness of Generic Acetazolamide

“…Serum levels of acetazo¬ lamide were determined by high-pressure liquid chromatography analysis as de¬ scribed by Gal and co-workers. 1 Six pharmacies in the Denver area were contacted to establish comparative costs of the acetazolamide products. Brand-name acetazolamide was obtained from the Uni¬ versity of Colorado Hospital pharmacy, Denver, as scored 250-mg tablets.…”

Tb -4'carboxybenzo-18crown-6-ether Photo Probe or the Assessment of Nalbuphin HCl in Serum and Pharmaceutical Formulations

“…Luminescent photo probes lanthanide complexes have more advantages over the present ones; photo probe has high stability and durability. The photo probe can provide constant signal response for 2 years which is 24-fold better stability compared to the life time warranted for the chromatographic and colorimetric methods [6][7][8][9][10][11][12][13][14]. Photo probe is stable over all measurements which prevent the source of error in the measurement process and it gives a low standard deviation values.…”

Validated Stability indicating Spectrophotometric Method for the Determination of Acetazolamide in Dosage Forms through Complex Formation with Palladium (II)

“…It acts on the central nervous system to retard the abnormal, paroxysmal, and excessive discharge from CNS neurons (1). Various methods were reported for its determination either per se or in pharmaceutical preparations and biological fluids including: spectrophotometry (2)(3)(4)(5)(6), HNMR (4), electrochemical methods (7,8), and HPLC (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The British Pharmacopoeia (BP) (28) recommended potentiometric determination of ACM in dimethylformamide using ethanolic solution of sodium hydroxide as a titrant, while the United States Pharmacopoeia (USP) method (29) recommended a spectrophotometric measurement of the acidic solution of the pharmaceutical preparation at 265 nm.…”

Effectiveness of Generic Acetazolamide

“…Serum levels of acetazo¬ lamide were determined by high-pressure liquid chromatography analysis as de¬ scribed by Gal and co-workers. 1 Six pharmacies in the Denver area were contacted to establish comparative costs of the acetazolamide products. Brand-name acetazolamide was obtained from the Uni¬ versity of Colorado Hospital pharmacy, Denver, as scored 250-mg tablets.…”

Tb -4'carboxybenzo-18crown-6-ether Photo Probe or the Assessment of Nalbuphin HCl in Serum and Pharmaceutical Formulations

“…Luminescent photo probes lanthanide complexes have more advantages over the present ones; photo probe has high stability and durability. The photo probe can provide constant signal response for 2 years which is 24-fold better stability compared to the life time warranted for the chromatographic and colorimetric methods [6][7][8][9][10][11][12][13][14]. Photo probe is stable over all measurements which prevent the source of error in the measurement process and it gives a low standard deviation values.…”

Validated Stability indicating Spectrophotometric Method for the Determination of Acetazolamide in Dosage Forms through Complex Formation with Palladium (II)

“…It acts on the central nervous system to retard the abnormal, paroxysmal, and excessive discharge from CNS neurons (1). Various methods were reported for its determination either per se or in pharmaceutical preparations and biological fluids including: spectrophotometry (2)(3)(4)(5)(6), HNMR (4), electrochemical methods (7,8), and HPLC (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The British Pharmacopoeia (BP) (28) recommended potentiometric determination of ACM in dimethylformamide using ethanolic solution of sodium hydroxide as a titrant, while the United States Pharmacopoeia (USP) method (29) recommended a spectrophotometric measurement of the acidic solution of the pharmaceutical preparation at 265 nm.…”