Determination of a diabetes control and complications trial-aligned HbA1c reference range in pregnancy

O’Kane, Maurice; Lynch, P L Mark; Moles, Kenneth W.; Magee, Sara

doi:10.1016/s0009-8981(01)00579-4

Cited by 31 publications

(29 citation statements)

References 12 publications

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“…Our findings are in good agreement with those obtained by Nielsen et al (26 ), who demonstrated a decrease of the upper reference limit of Hb A 1c from 6.3% before pregnancy to 5.7% in early pregnancy and 5.6% in the third trimester. A decrease in the upper reference limit for Hb A 1c was also reported by O'Kane et al (27 ), who determined an upper limit of 5.9% in nondiabetic pregnant women and 6.5% in the general population. Data from other authors, although not as comparable because they were obtained on a smaller number of individuals or by Hb A 1c methods not aligned to the DCCT, also indicated decreased Hb A 1c concentrations during uncomplicated pregnancies (8 -10 ).…”

Section: Discussionsupporting

confidence: 74%

“…Controversial data are re- ported in the literature about this point: some authors confirmed this finding (28 ), whereas others did not detect differences among trimesters (27 ) or reported an additional decrease in Hb A 1c values in late pregnancy (26 ). These lower Hb A 1c concentrations found in pregnancy might be related to the decrease in plasma glucose values and to the shortened erythrocyte life span that occur during pregnancy (29 ).…”

Section: Discussionmentioning

confidence: 99%

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Reference Intervals for Hemoglobin A1c in Pregnant Women: Data from an Italian Multicenter Study

et al. 2006

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Reference Intervals for Hemoglobin A1c in Pregnant Women: Data from an Italian Multicenter Study

et al. 2006

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“…In addition to home blood glucose measurement, which may not always reflect the true average blood glucose level (4), HbA 1c is a useful parameter in metabolic regulation (5)(6)(7)(8). Thus, supplementation with HbA 1c , as is common outside pregnancy, seems appropriate.…”

mentioning

confidence: 99%

“…However, the upper normal range of HbA 1c during normal pregnancy is only sparsely investigated with different methods (10), mainly in late pregnancy (5,6,11,12), and reference ranges are generally established from the nonpregnant state (4). Increased third-trimester HbA 1c levels are associated with an increased risk of preeclampsia (3,13), macrosomia (1), and stillbirth (2), leading to speculations that the target for HbA 1c in pregnancy should be even lower than outside pregnancy to prevent adverse events.…”

mentioning

confidence: 99%

HbA1c Levels Are Significantly Lower in Early and Late Pregnancy

et al. 2004

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“…HbA1c'nin sağlıklı gebelerde gebelik ön-cesi duruma göre azaldığı bilinmektedir ancak yüksek, düşük ve anlamsız fark bulan çalışmalar da mevcuttur [18][19][20][21][22][23][24]. Gebeliğin ilk trimestrindeki düşük HbA1c düze-yi; düşük ortalama açlık ve tokluk kan şekeri değerleri ve genç eritrositlerdeki artış ile açıklanabilir [25].…”

Section: Gereç Ve Yöntemunclassified

Importance of HbA1c and Fructosamine As A Marker Of Glycemic Control and Evaluation Of Some Biochemical Parameters During Pregnancy

Seker¹,

Özdemir²,

Çağlar³

et al. 2014

Turk J Bioch

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Objective: Controlling and monitoring the diabetes during pregnancy, because of the malformation, macrosomia and other complications is especially important. Our study is designed to investigate the reliability of the two most commonly used parameter is the hemoglobin A1c (HbA1c) and fructosamine during pregnancy. Also among our study group, serum total protein, albumin, vitamin B12, folic acid, glucose, insulin, ferritin and hemoglobin data were evaluated. Methods: The study groups are pregnant women (n=252; age mean: 27,761± 5/year) and control group (n=28; age mean: 28,61± 5,38/year) who are no additional health problems. Diabetic pregnant women number is 124 (consisted of 10 first trimester, 62 second trimester and 52 third trimester) and nondiabetic pregnant women number is 138 (consisted of 24 first trimester, 32 second trimester and 82 third trimester). All measurement data are obtained from hospital information system. Results: No statistically significant difference in any of the groups for HbA1c. It's clearly observed that all the significant differences found for fructosamine occur depending on the level of albumin and fructosamine levels decreased progressively during the three trimesters. In our diabetic pregnant women group; although statistically make a difference; mean blood glucose values were below our expectations. Conclusion: Our study is support that fructosamine and HbA1c are unavailable for diagnosis and monitoring the gestational diabetes. However the lack of difference between the groups for levels of fructosamine and HbA1c; and blood glucose levels below our expectations in diabetic pregnant women group can be connected good diabetes control. Key Words: Pregnancy, fructosamine, HbA1c, glycemic control Conflict of Interest: The authors declare no conflict of interest. ÖZETAmaç: Diyabetin kontrol ve monitorizasyonu fetal malformasyon, makrozomi ve diğer komplikasyonlar nedeniyle gebelikte özellikle önemlidir. Çalışmamız, monitorizasyonda en sık kullanılan iki parametre olan hemoglobin A1c (HbA1c) ve fruktozaminin gebelik döneminde güvenilirliğinin araştırılması amacıyla tasarlanmış; ayrıca çalışma gruplarımızda serum total protein, albümin, vitamin B12, folat, glukoz, insülin, ferritin ve hemoglobin verileri de değer-lendirilmiştir. Metod: Çalışma grupları; ek sağlık problemi olmayan gebeler (n=252; ort. yaş: 27,761± 5/ yıl) ve kontrol grubu (n=28; ort. yaş: 28,61± 5,38/yıl)'ndan oluşmuştur. Diyabetik gebe grubu 124 (10'u ilk, 62'si ikinci ve 52'si üçüncü trimestrde); nondiyabetik gebe grubu ise 138 kişiden (24'ü ilk, 32'si ikinci ve 82'si üçüncü trimestrde) oluşmuştur. Bütün ölçüm verileri hastane bilgi sisteminden sağlanmıştır. Bulgular: Grupların hiçbirinde HbA1c için istatistiksel olarak anlamlı fark bulunamamıştır. Fruktozamin için bulunan anlamlı farkların da albümine bağlı olarak oluştuğu net olarak görül-müş ve fruktozamin düzeyleri trimestrler boyunca progresif olarak azalmıştır. Diyabetik gebe grubumuzda elde ettiğimiz ortalama kan şekeri değeri diğer gruplara kıyasla is...

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Determination of a diabetes control and complications trial-aligned HbA1c reference range in pregnancy

Cited by 31 publications

References 12 publications

Reference Intervals for Hemoglobin A1c in Pregnant Women: Data from an Italian Multicenter Study

Reference Intervals for Hemoglobin A1c in Pregnant Women: Data from an Italian Multicenter Study

HbA1c Levels Are Significantly Lower in Early and Late Pregnancy

Importance of HbA1c and Fructosamine As A Marker Of Glycemic Control and Evaluation Of Some Biochemical Parameters During Pregnancy

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