Determinants of Infertility in Couples

Tamrakar, Suman Raj; Bastakoti, Rashmi

doi:10.33314/jnhrc.v17i01.1827

Cited by 71 publications

(59 citation statements)

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“…3 We found the mean age at which couples seek treatment is 27.25 ± DOI: 10.3126/jpn.v10i2.27267 4.12 years, similar to reports from other researchers. 4,10 This mean age is also near to the documented global mean age of childbearing since 1970. 3 In the age below 20 years and above 45 years, fewer couples are seeking a child.…”

Section: Discussionmentioning

confidence: 63%

Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study

et al. 2020

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Background: Infertility is a critical component of reproductive health that can precipitate agony for a couple. Antibodies against thyroid peroxidase can lead to not only autoimmune thyroiditis which is highly prevalent in women, but may also represent a generalized autoimmune milieu in our body that can be associated with infertility. This study aims to assess anti-thyroid peroxidase antibodies in female patients with infertility. Materials and Methods: This is a cross-sectional study carried out in the Department of Biochemistry, Tribhuvan University Teaching Hospital over three months (November 2018 to January 2019). All women undergoing work up at the infertility clinic with reported normal thyroid function and otherwise normal levels of reproductive hormones were recruited for this study. Anti-thyroid peroxidase levels were estimated in their serum samples by enzyme-linked immunosorbent assay. Results: Of the eighty-seven females that were selected for the study, 54 were infertile females, 16 were pregnant women in their first trimester and 17 were non-pregnant females in their reproductive age. Four positive cases of anti-thyroid peroxidase were detected among infertile females (7.4% within the group), 2 amid non-pregnant females (11.76% within-group) while no positive cases were detected within the pregnant group. However, the occurrence was not statistically significant (p=0.4). The pregnant group showed higher mean anti-thyroid peroxidase levels compared to both infertile and non-pregnant females though statistical significance could not be established (p=0.066). Conclusions: Functional autoimmune antibodies, like anti-thyroid peroxidase levels, do not have a significant primary association with infertility.

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Section: Discussionmentioning

confidence: 63%

Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study

et al. 2020

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“…A large study comprise of ten years told male factor identified in 23.9% and abnormality in semen analysis in 22.7% and sexual dysfunction in 1.2% only. 13 Similarly another study showed male infertility in 40% subfertile couples. 14 The study by KoboriY tells male factors infertility in 50% of couples.…”

Section: Discussionmentioning

confidence: 93%

“…It also guides to fertility and not a certain proof of fertility of an individual except in cases of azoospermia where cumulative conception rate is zero. 13 The study highlighted that male factor exclusively contribute about 32% to subfertility. In study conducted in Nigeria showed male factor in 52.38%.…”

Section: Discussionmentioning

confidence: 97%

Frequency of male factor and abnormalities of semen analysis in infertile couple.

Fayyaz

Tabassum

Qadir

2020

TPMJ

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Infertility is global health issue. Male factor contribute to infertility in more than half of sub fertile couples. Their diagnosis is easy by simple test of husband semen analysis. This study has been designed to know the contribution of male factor and frequency of abnormalities of semen in infertile couple. Objectives: To determine the frequency of male factor in infertile couple and to evaluate the different abnormalities in semen. Study Design: Descriptive study. Setting: Department of Obstetrics and Gynecology in Nishtar Hospital Multan. Period: From January 2019 to June 2019. Material & Methods: Study started after taking approval from hospital ethical committee. Study included 200 subfertile couples after informed consent attending the outpatient department. The partner of female attending the fertility clinic between ages 20-40 were selected. History taken from female partner regarding age, duration of subfertility, type of subfertility any drug intake and medical illness of male. Result: Among 200 couples 64(32%) had abnormal semen parameters.24 had oligospermia. Eight had azoospermia and 60 had asthenospermia. 20 patients had teratospermia. Conclusion: Male factor is significant contributor of infertility therefore awareness is needed in order to engage more males partner in evaluation and management of infertility.

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“…Infertility affects about 10-15% of couples worldwide and has become an increasingly common health problem (Tamrakar and Bastakoti, 2019). In recent years, assisted reproductive technology (ART) has become an important treatment for many women suffering from infertility.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Biallelic TLE6 Variants in Female Infertility With Preimplantation Embryonic Lethality

et al. 2021

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Preimplantation embryonic lethality is a rare cause of primary female infertility. It has been reported that variants in the transducin-like enhancer of split 6 (TLE6) gene can lead to preimplantation embryonic lethality. However, the incidence of TLE6 variants in patients with preimplantation embryonic lethality is not fully understood. In this study, we identified four patients carrying novel biallelic TLE6 variants in a cohort of 28 patients with preimplantation embryonic lethality by whole-exome sequencing and bioinformatics analysis, accounting for 14.29% (4/28) of the cohort. Immunofluorescence showed that the TLE6 levels in oocytes from patients were much lower than in normal control oocytes, suggesting that the variants result in the lower expression of the TLE6 protein in oocytes. In addition, a retrospective analysis showed that the four patients underwent a total of nine failures of in vitro fertilization and intracytoplasmic sperm injection attempts, and one of them became pregnant on the first attempt using donated oocytes. Our study extends the genetic spectrum of female infertility caused by variants in TLE6 and further confirms previously reported findings that TLE6 plays an essential role in early embryonic development. In such case, oocyte donation may be the preferred treatment.

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Determinants of Infertility in Couples

Cited by 71 publications

References 0 publications

Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study

Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study

Frequency of male factor and abnormalities of semen analysis in infertile couple.

Identification of Novel Biallelic TLE6 Variants in Female Infertility With Preimplantation Embryonic Lethality

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