Determinants of bronchial responsiveness at school age in prematurely born children

Nikolajev, Kari; Heinonen, Kirsti; Koskela, Heikki; Korppi, Matti; Länsimies, Esko; Jokela, Veikko

doi:10.1002/(sici)1099-0496(199912)28:6<408::aid-ppul4>3.0.co;2-m

Cited by 9 publications

(8 citation statements)

References 14 publications

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“…[26] In contrast, lung fl ows were affected more than FVC in the present study, as was observed in the study of lung function in infancy. [12][13][14][15] At early age in this cohort, the degree of bronchial reactivity, measured by cold air challenge, methacholine challenge and exercise challenge by free running outdoors, [18,19] was not associated with the intrauterine Birth weight and adult lung function Original article growth pattern. In the present study, bronchial hyperreactivity was present in less than 6 years earlier in the former IUGR children only.…”

Section: Discussionmentioning

confidence: 99%

“…As described, [17][18][19] a group of 67 children, born at Birth weight and adult lung function: a within-pair analysis of twins followed up from birth Kari Nikolajev, Heikki Koskela, Matti Korppi…”

Section: Subjectsmentioning

confidence: 99%

“…Isocapnic hyperventilation of cold air (IHCA) was carried out in a warm room as described in details earlier. [18,22,23] By using the base-line FEV1 value, the target minute ventilation was set to FEV1 × 25. Carbon dioxide was added to the inspired air, and the fl ow was calculated as the target minute ventilation ×0.05.…”

Section: Cold Air Challengementioning

confidence: 99%

“…The maximal fall in FEV1, calculated from the highest prechallenge and the lowest post-challenge FEV1, was used to express the response, and a fall of >9% was considered as pathological. [18,23] …”

Section: Original Articlementioning

confidence: 99%

“…[16] A group of children with disproportional intrauterine growth pattern from multiple pregnancies were followed up for 14 to 22 years from birth. [17][18][19] The present study was undertaken to evaluate the association of the intrauterine growth pattern with lung function and bronchial reactivity at teen age and in early adulthood using a within-pair analysis.…”

Section: Introductionmentioning

confidence: 99%

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Birth weight and adult lung function: a within-pair analysis of twins followed up from birth

2008

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Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Cold Air Challengementioning

confidence: 99%

Section: Original Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Birth weight and adult lung function: a within-pair analysis of twins followed up from birth

2008

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Determinants of bronchial responsiveness to methacholine at school age in twin pairs

Nikolajev

Korppi

Remes

et al. 2002

Pediatric Pulmonology

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The methacholine inhalation challenge test (MIC) was used to evaluate bronchial responsiveness in 67 children who were the products of multiple pregnancies when they were 7-15 years old. At birth, 30 (45%) infants had intrauterine growth retardation (IUGR; birth weight <2 SD below normal birth weight, or birth weight difference >1.3 SD between twin-pairs), and 59 (88%) were born before 37 weeks of gestation. None of the children had doctor-diagnosed asthma. The provocative dose of methacholine causing a 20% fall in Wright's peak expiratory flow (WPEF) (PD20) was below 1,000 microg in 10 (15%) children, and they were classified as MIC responders. There were no differences in perinatal or neonatal factors between MIC responders and nonresponders; in particular, MIC responses did not differ between IUGR infants, and children with appropriate growth for gestational age (AGA) at birth. There were seven discordant pairs in which one child was a MIC responder and the other was not; 5 responders were IUGR, and 2 were AGA children (ns). Respiratory tract infections after the neonatal period were equally common in IUGR and AGA children. However, these infections were associated with later bronchial hyperresponsiveness. Doctor-diagnosed respiratory infections, numbers of antibiotic courses, episodes of otitis media, and the need for adenoidectomy, tonsillectomy, and tympanostomy were more common in MIC responders than in nonresponders. We conclude that IUGR was not associated with subsequent bronchial hyperresponsiveness in twin pairs assessed by the MIC test. A significant relationship was seen between bronchial hyperresponsiveness and infections after the neonatal period.

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Epidemiology of Asthma and Allergic Diseases

Tang¹,

Matsui²,

Wiesch³

et al. 2009

Middleton's Allergy: Principles and Practice

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Determinants of bronchial responsiveness at school age in prematurely born children

Cited by 9 publications

References 14 publications

Birth weight and adult lung function: a within-pair analysis of twins followed up from birth

Birth weight and adult lung function: a within-pair analysis of twins followed up from birth

Determinants of bronchial responsiveness to methacholine at school age in twin pairs

Epidemiology of Asthma and Allergic Diseases

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