Determinants and trends in perinatal human immunodeficiency virus type 1 (HIV-1) transmission in the metropolitan area of Belo Horizonte, Brazil: 1998 - 2005

Kakehasi, Fabiana Maria; Pinto, Jorge; Romanelli, Roberta Maia de Castro; Carneiro, Mariângela; Cardoso, Carolina; Tavares, Maria do Carmo; Melo, Victor Hugo; Aguiar, Regina Amélia Lopes Pessoa de

doi:10.1590/s0074-02762008000400007

Cited by 24 publications

(33 citation statements)

References 38 publications

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“…In the data presented herein, the number of previous pregnancies, antenatal care visits and vaginal deliveries were not associated with HIV-1 maternal transmission. Vaginal delivery is strongly associated with an elevated risk of HIV-vertical transmission particularly in mothers with low levels of CD4 + T lymphocytes and elevated HIV-viral load counts (ORNE- GLIEMANN et al, 2008;KAKEHASI et al, 2008). Regarding the mode of delivery, elective cesarean sections were performed in 76.8% of the pregnancies, independent of previous ARV regimen or viral-load counts, reflecting the high frequency of cesarean sections performed in Brazil (MENEZES SUCCI, 2007).…”

Section: Discussionmentioning

confidence: 99%

HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil

Prestes-Carneiro

Spir

Ribeiro

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYIn children, vertical transmission is the main form of HIV infection. Our aim was to determine the prevalence of HIV-1 vertical transmission in mother-infant pairs in a public maternity ward in Presidente Prudente, SP. Additionally; we sought to identify characteristics associated with this form of transmission. The files of 86 HIV-1-infected mothers and their newborns referred to a Public Hospital from March 2002 to March 2007 were analyzed. The HIV-1-RNA viral load of the newborns was determined by bDNA. The HIV-1 vertical-transmission rate was 4.6%. Children that were born in the pre-term period and breastfed were at a higher risk of HIV-1 infection (p = 0.005 and p = 0.017 respectively) than children born at term and not breastfed. Prophylactic therapy with zidovudine after birth for newborns was associated with a lower risk of infection (p = 0.003). The number of newborns weighing < 2,500 g was significantly higher for infected children (p = 0.008) than for non-infected newborns. About 22.9% of mothers did not know the HIV-1 status of their newborns eight months after delivery. The study suggests that it is necessary to increase the identification of HIV-1 infection in pregnant women and their newborns as well as to offer and explain the benefits of ARV prophylaxis.

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Section: Discussionmentioning

confidence: 99%

HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil

Prestes-Carneiro

Spir

Ribeiro

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…Esta medida, em nosso país, vem reduzindo a transmissão vertical a taxas inferiores a 4%, de acordo com relatos recentes 15 . A prevalência das doenças do trato genital inferior associada ao HIV-1 (24%) foi menor em nosso estudo em relação a outro realizado em Salvador 16 .…”

Section: Discussionunclassified

Diversidade genética do vírus da imunodeficiência humana tipo 1 (HIV-1) em mulheres infectadas de uma cidade do nordeste do Brasil

Santos¹,

Araújo²,

Galvão–Castro³

et al. 2009

Rev. Bras. Ginecol. Obstet.

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“…These results are in agreement with our previous report that showed a decrease of HIV vertical transmission (from 20-3%) during a seven-year period (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005) among pregnant women who used these prophylactic procedures. In this study, vaginal delivery was associated with an increased risk for MTCT (odds ratio: 3,3; 95% confidence interval: 1,8-5,8) (Kakehasi et al 2008).…”

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confidence: 51%

“…Maternal and neonatal samples were collected immediately after delivery to determine the plasma VL. Uninfected infants were defined as those who tested negative in two separate plasma VL assays performed at four weeks old or those who seroreverted (a negative serologic test performed after 12 months of age) (Kakehasi et al 2008).…”

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confidence: 99%

HIV-1 RNA detection in the amniotic fluid of HIV-infected pregnant women

Lobato¹,

Aguiar²,

Aleixo³

et al. 2010

Mem. Inst. Oswaldo Cruz

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This study is aimed at evaluating the potential to detect human immunodeficiency virus (HIV) in amniotic fluid (AF) collected at delivery from 40 HIV-positive pregnant women. Thirty patients had a plasma viral load (VL) below 1,000 copies/mL at delivery. VL was positive in three AF samples. No significant association was found between the HIV-1 RNA in AF and the maternal plasma samples. There was no HIV vertical transmission detected

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Determinants and trends in perinatal human immunodeficiency virus type 1 (HIV-1) transmission in the metropolitan area of Belo Horizonte, Brazil: 1998 - 2005

Abstract: Significant decrease in human immunodeficiency virus type 1 (HIV-1) vertical transmission has been observed

Cited by 24 publications

References 38 publications

HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil

HIV-1-mother-to-child transmission and associated characteristics in a public maternity unit in Presidente Prudente, Brazil

Diversidade genética do vírus da imunodeficiência humana tipo 1 (HIV-1) em mulheres infectadas de uma cidade do nordeste do Brasil

HIV-1 RNA detection in the amniotic fluid of HIV-infected pregnant women

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