Determinação de paracetamol pela inibição da reação quimiluminescente do luminol-hipoclorito de sódio em um sistema de análise em fluxo empregando o conceito de multicomutação

Oliveira, Geiser Gabriel; Janegitz, Bruno C.; Batistão, Marina Beghini; Salami, Fernanda Helena; Fatibello‐Filho, Orlando; Leite, Oldair Donizeti

doi:10.1590/s0100-40422009000700014

Cited by 12 publications

(3 citation statements)

References 16 publications

(22 reference statements)

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“…On the other hand, many spectrophotometric methods were used for the determination of PCM [43][44][45][46][47]. PCM was also determined by FIA techniques with the different detectors, such as a spectrophotometer [48][49][50][51][52], a spectrofluorometer [53,54], an amperometer [55,56] and a chemiluminescence meter [57,58], and several other analytical methods, including titrimetric [59,60], electrochemical [61][62][63][64][65][66], fluorimetric [67][68][69] and HPLC [70][71][72] methods.…”

Section: Introductionmentioning

confidence: 99%

Double injection–single detector flow injection spectrophotometric method for simultaneous determination of ascorbic acid and paracetamol in pharmaceutical formulations

Muhammad

Faizullah

2019

J IRAN CHEM SOC

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A simple and low-cost flow injection spectrophotometric method was proposed for the simultaneous determination of ascorbic acid (AA) and paracetamol (PCM) in pharmaceutical formulations. The present method is based on the reduction of Fe(III) to Fe(II) with AA and PCM in a closed flow system which subsequently combines with the 1,10-phenanthroline to form an orange-coloured complex that is measured at 510 nm. The increase in the absorbance was proportional to the concentration of AA in the range of 0.1-12 µg/ml with a correlation coefficient of 0.9997 and detection limit of 0.31 µg/ml, and to the concentration of PCM in the range of 0.4-24 µg/ml with a correlation coefficient of 0.9999 and detection limit of 0.39 µg/ml. The precision for ten serial estimations of 2 and 7 µg/ml of AA exhibited a relative standard deviation of 3.33% and 2.47% and of 6 and 15 µg/ml of PCM with a relative standard deviation of 3.008% and 2.23%, respectively. The present FI method permits determination of 9 samples per hour with no interference from the common excipients. The developed method was applied to different tablets containing AA and PCM with the recovery of AA from four spiked samples ranged from 95.31 to 104.73%, and of PCM ranged from 95.03 to 104.93%.

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Section: Introductionmentioning

confidence: 99%

Double injection–single detector flow injection spectrophotometric method for simultaneous determination of ascorbic acid and paracetamol in pharmaceutical formulations

Muhammad

Faizullah

2019

J IRAN CHEM SOC

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“…1,2 Therefore, the determination of acetaminophen in drug formulations is an important matter for medical and pharmaceutical research. 3 Various analytical methods including high performance liquid chromatographic method, 4,5 spectrophotometry, 6,7 capillary electrophoresis, 8,9 chemiluminescence 10,11 and electrochemical method [12][13][14][15] have been reported for the determination of acetaminophen. Among the above analytical methods, the electrochemical method has more advantages such as relatively low cost, fast response, high sensitivity, simple sample pretreatment and low power requirement.…”

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confidence: 99%

Fabrication of Carbon@Co Nanocages/Nafion/Poly Tiopronin Composite Film and Its Application for Determination of Acetaminophen

Zhou¹,

Ye²,

Zheng³

et al. 2017

J. Electrochem. Soc.

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The carbon@Co nanocages/nafion/poly tiopronin composite film modified glassy carbon electrode (GCE) was prepared for the first time. The poly tiopronin was constructed by electropolymerization of tiopronin on the surface of GCE and the carbon@Co nanocages fabricated by the calcination of Co-based MOF (ZIF-67) under Ar atmosphere. The structure and surface morphology of the prepared carbon@Co nanocages were characterized using X-ray diffraction, scanning and transmission electron microscopy. The electrochemical behavior of acetaminophen on the carbon@Co nanocages/nafion/poly tiopronin composite film modified electrode was studied. The results showed that the modified electrode had good electrocatalytic activity to the oxidation and reduction of acetaminophen. Under optimal conditions, the oxidation peak current increased with the concentration of acetaminophen in the range of 0.5∼225 μM, with a detection limit of 0.17 μM. The method was applied to the determination of acetaminophen in the real sample with a RSD less than 3.27% and the recovery range of 97.9∼103.0%. These results indicate that the carbon@Co nanocages/nafion/poly tiopronin composite is a promising platform for fabricating electrochemical sensor.

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“…Inhibition of CL of the luminol/hypochlorite system was further exploited for determination of paracetamol. 215 Photochemical derivatization and detection by fluorescence was adopted for determination of cyclofenil 216 and erythromycin 217 in pharmaceuticals. The detection limits were estimated as 0.011 mmol L -1 and 25 mg L -1 , respectively, with linear dynamic ranges extended up to 4 concentration decades.…”

mentioning

confidence: 99%

Analytical chemistry in Brazil: healthy and growing

Rocha

Pereira-Filho²,

Nóbrega³

2009

J. Braz. Chem. Soc.

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A química brasileira está crescendo rapidamente, sendo um dos principais alicerces para o contínuo desenvolvimento do país. Inspirados no 15º Encontro Nacional de Química Analítica, ENQA, com um número recorde de participantes e comunicações, decidiu-se revisar os recentes desenvolvimentos em química analítica no Brasil. Foram escolhidas as mesmas áreas de aplicação adotadas para a organização temática do ENQA e selecionados artigos publicados por autores brasileiros em 7 periódicos de ampla penetração na área. Os dois periódicos científicos editados pela Sociedade Brasileira de Química também foram pesquisados. Esta revisão não é exaustiva, porém os trabalhos selecionados após 2008 mostram uma significativa visão geral da área. Pode-se concluir que a química analítica brasileira está saudável, em crescimento e certamente atenderá as demandas do país como uma potência emergida.Chemical sciences in Brazil are growing fast and being one of the main supports for the continuous development of the country. Inspired on the 15 th Brazilian Meeting on Analytical Chemistry, ENQA, with a record number of participants and communications, we have decided to review recent developments in analytical chemistry in Brazil. We have chosen the same application areas used for the thematic organization of the ENQA and have searched papers published by Brazilian authors in 7 major and general journals in analytical chemistry. The two scientific journals published by the Brazilian Chemical Society were also searched. This review is not comprehensive, but the selected papers published after 2008 shown an impressive overview of the area. We may conclude that analytical chemistry is healthy and growing in Brazilian scenario and certainly will attend the demands of Brazil as an emerged power.

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Determinação de paracetamol pela inibição da reação quimiluminescente do luminol-hipoclorito de sódio em um sistema de análise em fluxo empregando o conceito de multicomutação

Cited by 12 publications

References 16 publications

Double injection–single detector flow injection spectrophotometric method for simultaneous determination of ascorbic acid and paracetamol in pharmaceutical formulations

Double injection–single detector flow injection spectrophotometric method for simultaneous determination of ascorbic acid and paracetamol in pharmaceutical formulations

Fabrication of Carbon@Co Nanocages/Nafion/Poly Tiopronin Composite Film and Its Application for Determination of Acetaminophen

Analytical chemistry in Brazil: healthy and growing

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