Detection of Tuberculous Mycobacteria in Sputum and Intensity of Bacillary Excretion in Tuberculosis Patients With Various Hiv Status

Зимина, В. Н.; Микова, О. Е.; Варецкая, Т. А.; Дегтярева, С. Ю.; Sergevnin, V. I.

doi:10.21292/2075-1230-2017-95-7-17-23

Tuberk. bolezni lëgk.

2017

DOI: 10.21292/2075-1230-2017-95-7-17-23

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Detection of Tuberculous Mycobacteria in Sputum and Intensity of Bacillary Excretion in Tuberculosis Patients With Various Hiv Status

В. Н. Зимина¹,

О. Е. Микова²,

Т. А. Варецкая³

et al.

Abstract: 1ФГАОУ ВО «Российский университет дружбы народов», Москва, Россия 2 ГКУЗ ПК «Пермский краевой центр по профилактике и борьбе со СПИД и инфекционными заболеваниями», г. Пермь, Россия 3 ГБОУ ВПО «Пермский государственный медицинский университет им. акад. Е. А. Вагнера», г. Пермь, Россия Цель исследования: изучить информативность выявления микобактерий туберкулеза (МБТ) различными методами и провести анализ массивности бактериовыделения у больных туберкулезом в зависимости от ВИЧ-статуса.Материалы и методы. Обсле… Show more

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Cited by 6 publications

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Manifestations of epidemic process of tuberculosis among HIV-infected patients and dependence of infection frequency on immunodeficiency level and HIV viral load

Sergevnin

Tukacheva

2022

Perm Medical Journal

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Objective. To assess the manifestations of the epidemic process of tuberculosis (TB) in HIV-infected persons and the frequency of infection depending on the level of immunodeficiency and viral load. Materials and methods. The epidemiological manifestations of TB incidence among HIV-infected and HIV-negative population of the Perm Region for 20142019 were studied. The frequency of TB in HIV-infected patients was determined depending on the level of immunodeficiency (96 patients) and viral load (61 patients). Results. On average, the incidence of TB among HIV-infected persons was by 36 times higher than that of noninfected persons. Among those infected and noninfected with HIV, TB was registered significantly more often among adults, and mainly men. The incidence of TB among HIV-infected persons is higher among urban population, while HIV-negative among rural residents. The incidence of TB in HIV-infected persons increases with an increase in the immunodeficiency and viral load. Conclusions. Persons with HIV infection are at risk for TB. The incidence of TB in HIV-infected persons increases with an increase in immunodeficiency and viral load.

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Manifestations of epidemic process of tuberculosis among HIV-infected patients and dependence of infection frequency on immunodeficiency level and HIV viral load

Sergevnin

Tukacheva

2022

Perm Medical Journal

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Peculiarities of Clinical and X-Ray Tangular Forms of Tuberculosis and Results of Its Etiological Diagnostics in Patients Concerned by Hiv+tb Infection in the Republic of Karelia

Pakhomova

Маркелов

Сунчалина³

et al. 2018

VIČ-infekc. immunosupr.

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The purpose of this study was to study the clinical and radiological forms of TB in patients with HIV and the possibilities of etiologic diagnosis-the detection of MBT using various methods for determining and the effect of immunosuppression on the results of etiologic diagnosis. Materials and methods. The materials for the study were the analysis of clinical x-ray examination data and the results of etiological diagnosis of the Office in the Republic of Karelia for the period from 2001 to 2016 among 159 patients with a co-infection of HIV+TB in the bacteriological laboratory of the Republican TB Dispensary of the Karelia. Results of the research. The peculiarities of clinical and radiological forms of tuberculosis (TB) and infomativity of various methods of etiologic diagnosis of TB among 159 patients with combined HIV+TB infection for the period 2001–2016 in the Republic of Karelia were studied. It was revealed that the PCR diagnostics significantly reduced the likelihood of a lethal outcome of patients with a co-infection, as it allowed us to quickly identify not only the presence of the MBT, but also to identify MDR and appoint adequate chemotherapy on the first day of detection, which significantly reduced the risk of death. The frequency of bacterial excretion most often (69%) occurred in the group of patients with the most severe immunosuppression with an amount of CD4 cells less than 100 in 1 ml. It was found that among the patients with co-infection with HIV + pulmonary TB, cavities of disintegration in the lung tissue (38,5%) are significantly less likely to be detected, but bacteriovirus (68,5%) is detected more frequently than among patients with pulmonary TB in the territory of the Republic of Karelia (form 33). It has been established that improving the organization of sputum collection can significantly increase (at least 20%) the incidence of MBT in patients with pulmonary TB and HIV, which is important in the rapid diagnosis of TB and the appointment of adequate therapy, especially considering that among patients with co-infection 1⁄2 (52,8%) had MDR. The conclusion. For the timely diagnosis of pulmonary TB in HIV-infected patients, with frequent atypical clinical and radiological picture of TB and the possibility of rapid progression with lethal outcome, and also taking into account the results obtained (in 56% of patients with TB+HIV-MBT+), etiologic diagnosis of TB has priority value. The most affordable, cheap and epidemiologically significant method for detecting TB is sputum smear microscopy. The epidemiological danger was aggravated by the detection in 52,8% of patients with HIV+TB strains of multidrug-resistant and extensively drug-resistant MBT.

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Long-Term Dynamics of HIV-Infected Mortality and Risk Factors of the Lethal Outcome in the Presence and Absence of Concomitant Tuberculosis

Sergevnin

Tukacheva

Микова

et al. 2023

Epidemiology and Vaccinal Prevention

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Relevance. The mortality rate of patients with HIV infection, including concomitant tuberculosis (HIV/TB), continues to increase. The goal of the work is to study the longterm dynamics of HIVinfected mortality and risk factors of the lethal outcome in the presence and absence of concomitant tuberculosis.Materials and methods. An assessment of the mortality rates of HIV-infected people among the population of the Perm Region during the period from 2005 (the year of registration of the first cases of HIV/TB) to 2021 was carried out. In order to determine the life expectancy of patients and risk factors of the lethal outcome the analysis of 414 outpatient records of HIVinfected people who died in 2021 was carried out. The degree of immunodeficiency and viral load in patients was taken into account based on the results of examinations conducted in the period 6 months before the lethal outcome.Results. During the 15year period of registration of the incidence of HIV/TB in the study area, 57.0% of those who died from causes directly related to HIV infection had TB. At the same time, despite the decrease in mortality from monotuberculous infection as a result of a decrease in the incidence of TB, in recent years there has been an increase in mortality from HIV/TB due to the intensification of the epidemic process of HIV infection. The average life expectancy of HIV-infected people who died directly from HIV infection in the absence of TB was 6.7 ± 0.3 years, with concomitant TB 5.7 ± 0.3 years. The lethal outcome of patients with HIV infection in the presence of TB and without TB was most often recorded with the number of CD4 + < 200 cells /ml and viral load > 100,000 copies /MBNA of HIV. At the same time, immunosuppression in deceased HIV/TB patients was more pronounced than in HIV-infected patients in the absence of TB.

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Detection of Tuberculous Mycobacteria in Sputum and Intensity of Bacillary Excretion in Tuberculosis Patients With Various Hiv Status

Cited by 6 publications

References 1 publication

Manifestations of epidemic process of tuberculosis among HIV-infected patients and dependence of infection frequency on immunodeficiency level and HIV viral load

Manifestations of epidemic process of tuberculosis among HIV-infected patients and dependence of infection frequency on immunodeficiency level and HIV viral load

Peculiarities of Clinical and X-Ray Tangular Forms of Tuberculosis and Results of Its Etiological Diagnostics in Patients Concerned by Hiv+tb Infection in the Republic of Karelia

Long-Term Dynamics of HIV-Infected Mortality and Risk Factors of the Lethal Outcome in the Presence and Absence of Concomitant Tuberculosis

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