Detection of trace amounts of insoluble pharmaceuticals in water by extraction and SERS measurements in a microfluidic flow regime

Burtsev, Vasilii; Erzina, Mariia; Guselnikova, Olga; Милютина, Елена; Kalachyova, Y.; Švorčı́k, Václav; Lyutakov, Oleksiy

doi:10.1039/d0an02360d

Cited by 22 publications

(16 citation statements)

References 52 publications

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“…The surface of 2D gold grating and optical fiber has been functionalized by spontaneous or electrochemical reduction using lipophilic ADSs with a long aliphatic chain for SERS sensing of cardiovascular disease markers [ 131 ] or water‐insoluble ibuprofen from wastewater. [ 132 ] Other useful groups for attachment are COOH and NH 2 due to their high reactivity with DNA, antibodies, and other bioactive molecules [ 18b–d ] or the possibility to promote the growth of MOFs/COFs. [ 111,133 ] Diazonium modification provides unique opportunities for the postfunctionalization of organic functional groups and the design of materials with high selectivity.…”

Section: The Nanoarchitecture Of Organic/plasmonic Heterostructuresmentioning

confidence: 99%

New Trends in Nanoarchitectured SERS Substrates: Nanospaces, 2D Materials, and Organic Heterostructures

Guselnikova

Lim

Kim

et al. 2022

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107

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This article reviews recent fabrication methods for surface‐enhanced Raman spectroscopy (SERS) substrates with a focus on advanced nanoarchitecture based on noble metals with special nanospaces (round tips, gaps, and porous spaces), nanolayered 2D materials, including hybridization with metallic nanostructures (NSs), and the contemporary repertoire of nanoarchitecturing with organic molecules. The use of SERS for multidisciplinary applications has been extensively investigated because the considerably enhanced signal intensity enables the detection of a very small number of molecules with molecular fingerprints. Nanoarchitecture strategies for the design of new NSs play a vital role in developing SERS substrates. In this review, recent achievements with respect to the special morphology of metallic NSs are discussed, and future directions are outlined for the development of available NSs with reproducible preparation and well‐controlled nanoarchitecture. Nanolayered 2D materials are proposed for SERS applications as an alternative to the noble metals. The modern solutions to existing limitations for their applications are described together with the state‐of‐the‐art in bio/environmental SERS sensing using 2D materials‐based composites. To complement the existing toolbox of plasmonic inorganic NSs, hybridization with organic molecules is proposed to improve the stability of NSs and selectivity of SERS sensing by hybridizing with small or large organic molecules.

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Section: The Nanoarchitecture Of Organic/plasmonic Heterostructuresmentioning

confidence: 99%

New Trends in Nanoarchitectured SERS Substrates: Nanospaces, 2D Materials, and Organic Heterostructures

Guselnikova

Lim

Kim

et al. 2022

Small

Self Cite

107

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“…A recent article by Burtsev et al. established a method for detecting and removing ibuprofen from water samples via microfluidic extraction and then capture by lipophilic functionalized gold multibranched nanoparticles (AuMs) 102 . This method did not require sample pre‐treatment, was reliable and reproducible and had a low LOD (1.2 × 10 –8 M).…”

Section: Analytes Of Interestmentioning

confidence: 99%

“…Injected into platform 10 -15 M [ 122] Silver nanoparticles Dezocine Spiked urine, blank urine sample and spike rat serum 10 μg/mL [268] Gold multibranched nanoparticles Ibuprofen Water 10 -8 M [ 102] Molecularly imprinted @ gold-graphene oxide Biguanides Health care capsules 0.10 mg/mL [105] Nanoporous gold nanoparticles Pharmaceuticals Substrate - [45] Silver nanodisks decorated filter paper Tetracycline Analyte dropped onto substrates surface 10 -9 M [46] Gold nanoparticles Sulfadiazine, sulfamerazine and sulfamethazine Water 1 and 50 μg/L [269] Gold nanowires Furazolidone Deionized water, running water, river and seawater 6.83 mg/L [69] (Continues)…”

Section: Congo Redmentioning

confidence: 99%

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Terry

Sanders

Potoff

et al. 2022

Analytical Science Advances

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As the human population grows, the anthropogenic impacts from various agricultural and industrial processes produce unwanted contaminants in the environment. The accurate, sensitive and rapid detection of such contaminants is vital for human health and safety. Surface-enhanced Raman spectroscopy (SERS) is a valuable analytical tool with wide applications in environmental contaminant monitoring. The aim of this review is to summarize recent advancements within SERS research as it applies to environmental detection, with a focus on research published or accessible from January 2021 through December 2021 including early-access publications. Our goal is to provide a wide breadth of information that can be used to provide background knowledge of the field, as well as inform and encourage further development of SERS techniques in protecting environmental quality and safety. Specifically, we highlight the characteristics of effective SERS nanosubstrates, and explore methods for the SERS detection of inorganic, organic, and biological contaminants including heavy metals, pharmaceuticals, plastic particles, synthetic dyes, pesticides, viruses, bacteria and mycotoxins. We also discuss the current limitations of SERS technologies in environmental detection and propose several avenues for future investigation. We encourage researchers to fill in the identified gaps so that SERS can be implemented in a real-world environment more effectively and efficiently, ultimately providing reliable and timely data to help and make science-based strategies and policies to protect environmental safety and public health.

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“…Surface-enhanced Raman scattering (SERS) spectroscopy is a well-known surface-sensitive technique used for the past four decades [1,2]. Due to its high sensitivity with unique fingerprinting capability, researchers across the globe use this technique in various fields like medical diagnosis [3][4][5][6][7], food safety and environmental monitoring [8][9][10][11], defense and security [12,13], pharmaceuticals [14][15][16], and so forth. In the SERS process, the scattered Raman signal from the test sample gets enhanced in the presence of noble metal nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticle decorated blu‐ray digital versatile disc as a highly reproducible surface‐enhanced Raman scattering substrate for detection and analysis of rotavirus RNA in laboratory environment

Biswas

Devi

Sarma

et al. 2022

Journal of Biophotonics

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Detection and estimation of various biomolecular samples are often required in research and clinical laboratory applications. Present work demonstrates the functioning of a surface‐enhanced Raman scattering (SERS) substrate that has been obtained by drop‐casting of citrate‐reduced gold nanoparticles (AuNPs) of average dimension of 23 nm on a bare blu‐ray digital versatile disc (BR‐DVD) substrate. The performance of the proposed SERS substrate has been initially evaluated with standard Raman active samples, namely malachite green (MG) and 1,2‐bis(4‐pyridyl)ethylene (BPE). The designed SERS substrate yields an average enhancement factor of 3.2 × 106 while maintaining reproducibility characteristics as good as 94% over the sensing region of the substrate. The usability of the designed SERS substrate has been demonstrated through the detection and analysis of purified rotavirus double‐stranded RNA (dsRNA) samples in the laboratory environment condition. Rotavirus RNA concentrations as low as 10 ng/μL could be detected with the proposed sensing scheme.

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Detection of trace amounts of insoluble pharmaceuticals in water by extraction and SERS measurements in a microfluidic flow regime

Abstract: Microfluidic extraction and subsequent SERS measurements are proposed for online detection of trace amounts of poorly water-soluble pharmaceuticals in relevant kinds of water-based solutions.

Cited by 22 publications

References 52 publications

New Trends in Nanoarchitectured SERS Substrates: Nanospaces, 2D Materials, and Organic Heterostructures

New Trends in Nanoarchitectured SERS Substrates: Nanospaces, 2D Materials, and Organic Heterostructures

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Gold nanoparticle decorated blu‐ray digital versatile disc as a highly reproducible surface‐enhanced Raman scattering substrate for detection and analysis of rotavirus RNA in laboratory environment

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