Detection of NDM-2-producing Acinetobacter baumannii and VIM-producing Pseudomonas aeruginosa in Palestine

Sjölander, Isabella; Hansen, Frank; Elmanama, Abdelraouf A.; Khayyat, Rasha; Abu-Zant, Alaeddin; Hussein, Ayman S.; Taha, Adham Abu; Hammerum, Anette M.; Ciofu, Oana

doi:10.1016/j.jgar.2013.11.002

Cited by 13 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Lazarovitch et al, 2015), and C. freundii (Castanheira et al, 2014) suggests a possible monoclonal spread of KPC in K. pneumoniae and its subsequent successful horizontal gene transfer to other species. Other carbapenemase producing GNB detected in Palestine involve: OXA-48 located in the IncL/M plasmid in P. mirabilis (Chen et al, 2015), VIM-2/VIM-4 P. aeruginosa in Palestine (Sjolander et al, 2014) and NDM-2/OXA-23/OXA-24 A. baumannii in both Israel and Palestine (Castanheira et al, 2014; Sjolander et al, 2014).…”

Section: Distribution Of Multi-drug Resistant Organisms In Humansmentioning

confidence: 99%

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

et al. 2019

View full text Add to dashboard Cite

In the last decade, extended-spectrum cephalosporin and carbapenem resistant Gram-negative bacilli (GNB) have been extensively reported in the literature as being disseminated in humans but also in animals and the environment. These resistant organisms often cause treatment challenges due to their wide spectrum of antibiotic resistance. With the emergence of colistin resistance in animals and its subsequent detection in humans, the situation has worsened. Several studies reported the transmission of resistant organisms from animals to humans. Studies from the middle east highlight the spread of resistant organisms in hospitals and to a lesser extent in livestock and the environment. In view of the recent socio-economical conflicts that these countries are facing in addition to the constant population mobilization; we attempt in this review to highlight the gaps of the prevalence of resistance, antibiotic consumption reports, infection control measures and other risk factors contributing in particular to the spread of resistance in these countries. In hospitals, carbapenemases producers appear to be dominant. In contrast, extended spectrum beta lactamases (ESBL) and colistin resistance are becoming a serious problem in animals. This is mainly due to the continuous use of colistin in veterinary medicine even though it is now abandoned in the human sphere. In the environment, despite the small number of reports, ESBL and carbapenemases producers were both detected. This highlights the importance of the latter as a bridge between humans and animals in the transmission chain. In this review, we note that in the majority of the Middle Eastern area, little is known about the level of antibiotic consumption especially in the community and animal farms. Furthermore, some countries are currently facing issues with immigrants, poverty and poor living conditions which has been imposed by the civil war crisis. This all greatly facilitates the dissemination of resistance in all environments. In the one health concept, this work re-emphasizes the need to have global intervention measures to avoid dissemination of antibiotic resistance in humans, animals and the environment in Middle Eastern countries.

show abstract

Section: Distribution Of Multi-drug Resistant Organisms In Humansmentioning

confidence: 99%

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Notably, we previously reported the pandrugresistant OXA-48-producing Proteus mirabilis and clonal spread of toxic shock syndrome toxin (TSST-1)-producing methicillin-resistant Staphylococcus aureus (MRSA) in the same area (16,17). In addition, ESBL-producing Escherichia coli and Klebsiella pneumoniae, NDM-2-producing Acinetobacter baumannii, and VIM-producing P. aeruginosa from Gaza have also been documented (18)(19)(20). Apparently, besides other challenges, Gaza is facing an antimicrobial resistance crisis as a result of the emergence of these highly multidrug-resistant organisms.…”

mentioning

confidence: 99%

Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine

Laham

Chavda

Cienfuegos-Gallet

et al. 2017

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed is harbored by a chromosomal genomic island among three strains, while is carried by a novel plasmid in two strains.

show abstract

“…OXA-23 production is the leading carbapenem resistance mechanism in A. baumannii, mostly associated with GC2 and GC1 (Hamidian and Nigro, 2019). Although ST103 strains were associated with NDM-2-producing isolates in Egypt, UAE, and Palestine (Kaase et al, 2011;Ghazawi et al, 2012;Sjölander et al, 2014), and an OXA-235-producing strain was reported in Australia (Hamidian et al, 2017), to the best of our knowledge this is the first study to identify ST103 associated with OXA-23 production (isolates Ab-B004d-c and Ab-D10a-a). Based on the occurrence of OXA-58 carbapenemase in several Acinetobacter species and in Proteus mirabilis (Fu et al, 2014;Feng et al, 2016;Lange et al, 2017;Matos et al, 2019), it has been suggested that horizontal gene transfer rather than clonal spread is the main mechanism of bla OXA−58 dissemination.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Characterization of Carbapenem-Hydrolyzing Class D β-Lactamase-Producing Acinetobacter Isolates From Ghana

et al. 2020

View full text Add to dashboard Cite

Detection of NDM-2-producing Acinetobacter baumannii and VIM-producing Pseudomonas aeruginosa in Palestine

Cited by 13 publications

References 16 publications

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine

Prevalence and Characterization of Carbapenem-Hydrolyzing Class D β-Lactamase-Producing Acinetobacter Isolates From Ghana

Contact Info

Product

Resources

About