Detection of myocardial ischaemia by epicardial accelerometers in the pig

Halvorsen, Per Steinar; Fleischer, Lars Albert; Espinoza, Andreas; Elle, Ole Jakob; Hoff, Lars; Skulstad, Helge; Edvardsen, Thor; Fosse, Erik

doi:10.1093/bja/aen331

Cited by 31 publications

(31 citation statements)

References 21 publications

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“…Two accelerometers sutured on the left ventricle (LV) surface in the perfusion areas of the left anterior descending (LAD) and circumflex (CX) arteries, measured acceleration in the longitudinal, circumferential, and radial directions, and the corresponding epicardial velocities were calculated. The accelerometer had the ability to distinguish ischaemia from interventions altering global myocardial function, by which the myocardial ischaemia can be monitored in a continuous real-time mode (Halvorsen et al, 2009). With the support of interventional techniques, intravascular ultrasound probe or intravascular Doppler velocimetry can be introduced into coronary artery and epicardial cross-sectional area and coronary flow velocity can be detected (Hutchison et al, 2005).…”

Section: Other Novel Methodologiesmentioning

confidence: 99%

Novel Porcine Models of Myocardial Ischemia/Infarction – Technical Progress, Modified Electrocardiograms Validating, and Future Application

Liu¹,

Li²

2012

Advances in Electrocardiograms - Clinical Applications

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Section: Other Novel Methodologiesmentioning

confidence: 99%

Novel Porcine Models of Myocardial Ischemia/Infarction – Technical Progress, Modified Electrocardiograms Validating, and Future Application

Liu¹,

Li²

2012

Advances in Electrocardiograms - Clinical Applications

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“…The animals were handled as described in detail in a previous study. 5 In short: The animals were anesthetized and a sternotomy was performed to get access to the heart. The accelerometer + gyro sensor (same sensor as described above) was fixed to the epicardial surface in the anterior, apical region of the left ventricle (Fig.…”

Section: In Vivo Experimentsmentioning

confidence: 99%

“…2 By measuring the cardiac motion using a miniaturized 3-axis accelerometer attached to the epicardial surface, previous studies have been able to distinguish between ischemic and normal conditions in pigs as well as humans. [3][4][5] Using an accelerometer to detect cardiac motion abnormalities might therefore prove beneficial when used in the intra-and post-operative phase.…”

Section: Introductionmentioning

confidence: 99%

Gravity Compensation Method for Combined Accelerometer and Gyro Sensors Used in Cardiac Motion Measurements

et al. 2017

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A miniaturized accelerometer fixed to the heart can be used for monitoring of cardiac function. However, an accelerometer cannot differentiate between acceleration caused by motion and acceleration due to gravity. The accuracy of motion measurements is therefore dependent on how well the gravity component can be estimated and filtered from the measured signal. In this study we propose a new method for estimating the gravity, based on strapdown inertial navigation, using a combined accelerometer and gyro. The gyro was used to estimate the orientation of the gravity field and thereby remove it. We compared this method with two previously proposed gravity filtering methods in three experimental models using: (1) in silico computer simulated heart motion; (2) robot mimicked heart motion; and (3) in vivo measured motion on the heart in an animal model. The new method correlated excellently with the reference (r > 0.93) and had a deviation from reference peak systolic displacement (6.3 ± 3.9 mm) below 0.2 ± 0.5 mm for the robot experiment model. The new method performed significantly better than the two previously proposed methods (p < 0.001). The results show that the proposed method using gyro can measure cardiac motion with high accuracy and performs better than existing methods for filtering the gravity component from the accelerometer signal.

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“…We have previously demonstrated the applicability of this technique in continuous monitoring of LV function in open and closed-chest experimental studies, and in patients undergoing off-pump coronary artery bypass grafting [5][6][7]. Epicardial systolic velocity as revealed by the accelerometer correlates with echocardiographic measurements during coronary occlusion [8], and a great advantage of the accelerometer is that automated signal analysis is possible [9].…”

Section: Introductionmentioning

confidence: 99%

Detection of intraoperative myocardial dysfunction by accelerometer during aortic valve replacement

Grymyr

Beitnes

Eidet

et al. 2016

Interact CardioVasc Thorac Surg

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OBJECTIVES: Myocardial dysfunction may occur during weaning from cardiopulmonary bypass (CPB). Epicardial accelerometers have been shown to be useful in continuous monitoring of myocardial ischaemia during beating-heart surgery. We aimed to investigate whether an accelerometer can detect myocardial dysfunction during weaning from CPB. METHODS:In 23 patients undergoing isolated aortic valve replacement (AVR), a three-axis accelerometer was attached to the left ventricle and 3D velocity was calculated from the signals. Peak early systolic velocity (V sys ) and velocity at aortic valve closure (V avc ) were measured. Measurements were undertaken during normothermia with 50% bypass flow and atrial pacing (90 beats/min) before aortic cross-clamping and after cross-clamp removal. Myocardial dysfunction was defined as V sys < V avc , and patients were classified as having normal function or dysfunction. Left ventricular (LV) stroke work via pulmonary artery catheter and systolic velocity by echocardiography were compared between groups and used as reference methods. RESULTS:The accelerometer identified a substantial proportion of patients with myocardial dysfunction during weaning from CPB, 56% of patients compared with 11% before aortic cross-clamping. Patients classified with normal myocardial function during weaning significantly improved their LV stroke work and systolic velocity by echocardiography in response to AVR, whereas those classified with dysfunction did not. Accelerometer classification of normal function predicted an increase in echocardiographic systolic velocity [r = 0.63, regression coefficient 1.98, 95% CI (0.57, 3.40) (P < 0.01)]. CONCLUSIONS:The accelerometer detected myocardial dysfunction during weaning from CPB in accordance with measures obtained by echocardiography and pulmonary artery catheter.Clinical Trials identifier: NCT01926067. https://clinicaltrials.gov/.

show abstract

Detection of myocardial ischaemia by epicardial accelerometers in the pig

Cited by 31 publications

References 21 publications

Novel Porcine Models of Myocardial Ischemia/Infarction – Technical Progress, Modified Electrocardiograms Validating, and Future Application

Novel Porcine Models of Myocardial Ischemia/Infarction – Technical Progress, Modified Electrocardiograms Validating, and Future Application

Gravity Compensation Method for Combined Accelerometer and Gyro Sensors Used in Cardiac Motion Measurements

Detection of intraoperative myocardial dysfunction by accelerometer during aortic valve replacement

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