Detection of Mycobacterium tuberculosis DNA in lobular granulomatous panniculitis (erythema induratum-nodular vasculitis)

Mycobacterium tuberculosis Infection Is Associated with the Development of Erythema Nodosum and Nodular Vasculitis

“…NV histologically presents a lobular panniculitis with granulomatous inflammation, vasculitis, focal necrosis, and septal fibrosis [8], [9]. NV has currently been considered as a multifactorial disorder and is associated with bacterial infection, such as streptococcus and MTB, and drug-related hyperreactivity, leading to the vascular inflammation of subcutaneous tissue and lobular panniculitis [7], [10].…”

Vasculitis in erythema induratum of Bazin: A histopathologic study of 101 biopsy specimens from 86 patients

“…11 In our country, tuberculosis is by far the most important causative factor for erythema induratum of Bazin, and recent polymerase chain reaction investigations have demonstrated Mycobacterium tuberculosis DNA in 77% of the cutaneous biopsy specimens of patients with this variant of panniculitis. 12 Although the frequency varies from some geographic areas to others, in many countries tuberculosis is still the main causative factor for erythema induratum of Bazin. [13][14][15][16][17][18][19][20] In contrast, in those countries with low prevalence of tuberculosis, this type of panniculitis may be a reactive process as a result of other causative factors such as obesity, cold climate, chronic venous insufficiency, or history of thrombophlebitis of the lower limbs.…”

Nodular tuberculid in a patient with HIV

“…Although PCR was not done in the originally reported 4 patients with NT, a positive PCR test can be expected in tuberculids as reported in EIB. 7 A study of tissue PCR to detect M tuberculosis DNA in different forms of cutaneous tuberculosis and tuberculids showed that although sensitivity of PCR can be as high as 100% in multibacillary and 73% of paucibacillary forms of cutaneous tuberculosis, PCR was only positive in 54% of EIB cases. 8 The negative tissue PCR in our case does not exclude the diagnosis of NT.…”