Detection of interleukin-8 (IL-8) in seminal plasma and elevated IL-8 in seminal plasma of infertile patients with leukospermia

Shimoya, Koichiro; Matsuzaki, Noboru; Tsutsui, Tateki; Taniguchi, Takeshi; Saji, Fumitaka; Takahashi, Osamu

doi:10.1016/s0015-0282(16)55876-2

Cited by 72 publications

(39 citation statements)

References 18 publications

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“…Also the IL-8 titre in seminal plasma of patients with leucocytospermia was found to be significantly higher than that in seminal plasma of infertile patients without leucocytospermia (Shimoya et al, 1993). In another study, the same authors reported on a close correlation among the levels of IL-6 and IL-8 in the seminal plasma (Shimoya et al, 1995).…”

Section: Introductionmentioning

confidence: 85%

Levels of interleukin-6 and interleukin-8 in seminal fluid of men attending an andrological clinic

et al. 2003

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The presence of interleukins (IL) and other cytokines in seminal plasma was demonstrated in the literature. In particular, the levels of IL-6 were found to be related to male accessory gland inflammation. The close correlation to leucocyte count indicates a production of interleukins from the leucocytes and by the prostate gland. No relation of IL-6 levels to spermatogenic activity was quoted in the literature. We measured IL-6 and IL-8 in 454 men and compared the values with seminal parameters. The mean values of IL-6 30.7 +/- 101.2 pg ml-1 and IL-8 2023 +/- 1721 pg ml-1. The correlation analysis revealed a significant correlation of IL-6 and/or IL-8 to age, total fructose, immunoglobulin G (IgG) concentration and leucocyte count. The significant correlation of IL-6 and fructose levels indicates that also the seminal vesicles take part in the production of seminal IL-6. No correlation of the two interleukins measured to sperm parameters occurred. The calculation of a single harmonic trend revealed a significant trend over the year of the levels of IL-6 with a maximum in December and a peak-to-trough variation of 33% of the mean. It may be the consequence of a higher frequency of seminal tract inflammations in autumn and winter.

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Section: Introductionmentioning

confidence: 85%

Levels of interleukin-6 and interleukin-8 in seminal fluid of men attending an andrological clinic

et al. 2003

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“…IL-8 levels in seminal plasma are considerably higher compared with serum plasma (Shimoya et al, 1993;Depuydt et al, 1996;Koumantakis et al, 1998), indicating a male genital tract (MGT) prevalence (Koumantakis et al, 1998). Examining urethral swab specimens collected from non-gonococcal urethritis, Chlamydia trachomatis-infected and uninfected males, Pate et al (2001) reported a modest, but significant, elevation of urethral IL-8 levels in subjects with chlamydial urethritis.…”

Section: Introductionmentioning

confidence: 99%

“…sIL-8 has been proposed as a potential marker for the diagnosis of male accessory gland infections (MAGI; Shimoya et al, 1993;Koumantakis et al, 1998;Eggert-Kruse et al, 2001). In particular, Shimoya et al, 1993 reported that IL-8 levels in seminal plasma of infertile patients with leucocytospermia were significantly higher compared with seminal plasma from infertile men without leucocytospermia or from fertile men. Furthermore, Koumantakis et al (1998) reported, in a limited series, an increased IL-8 concentration in seminal plasma from infertile subjects.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility

Lotti

Corona

Mancini

et al. 2010

International Journal of Andrology

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This study was aimed at evaluating the association between seminal plasma interleukin-8 (sIL-8) and colour-Doppler ultrasound (CDU) characteristics of the male genital tract in a series of patients fulfilling the criteria of male accessory gland infections (MAGI). Of 250 subjects seeking medical care for couple infertility, 79 (mean age: 36.4 ± 7.5 years) met the criteria of MAGI and scored higher than the rest of the sample on the National Institutes of Health-Chronic Prostatitis Symptom Index score. All patients underwent simultaneous hormone evaluation and seminal analysis (including sIL-8), along with scrotal and transrectal CDU before and after ejaculation. After adjusting for age, sIL-8 in patients with MAGI was significantly related to several abnormal semen and CDU parameters. In particular, leucocytospermia was closely associated with sIL-8. Ejaculate volume, unlike other semen or hormonal parameters, was negatively associated with sIL-8. When scrotal CDU was performed, sIL-8 was positively related to CDU inhomogeneous, hypo-echoic, hyper-echoic epididymis and to epididymal calcifications. In addition, a positive correlation among sIL-8, hyperaemic epididymis and an increased size of epididymal tail was found. When transrectal CDU was performed, an association among sIL-8 and hyper-echoic seminal vesicles, dilated ejaculatory ducts and duct calcifications was also observed. Finally, sIL-8 was positively related to prostate CDU abnormalities such as calcifications, inhomogeneous/hypo-echoic texture, hyperaemia and high arterial blood flow. No association was found with testis parameters. In conclusion, sIL-8 levels in patients with MAGI are associated with several parameters and CDU abnormalities of epididymis, seminal vesicles, ejaculatory ducts and prostate, but not of the testis. Furthermore, sIL-8 positively correlates with CDU signs of ejaculatory duct inflammatory subobstruction.

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“…Tissue damage caused by microbial pathogens is also associated with secretion of proinflammatory cytokines (Comhaire et al, 1999). Those in turn are frequent components of seminal fluid, and can be produced by leucocytes, fibroblasts and vascular endothelium (Shimoya et al, 1993). It was proven that bacteria stimulate the production of interleukin-1 (IL-1), but most of all the IL-8.…”

Section: Introductionmentioning

confidence: 99%

Consequences of semen inflammation and lipid peroxidation on fertilization capacity of spermatozoa in in vitro conditions

Jȩdrzejczak¹,

Frączek

Szumała-Kąkol

et al. 2005

Int J of Andrology

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A body of data exists on reactive oxygen species (ROS) release, however, no direct correlation was found between the oxidative stress and infertility. The aim of the study was to measure semen oxidative stress and its correlation with classical in vitro fertilization (IVF) rate. A prospective study in academic non-profit institution where 79 infertile couples were subjected to IVF programme was conducted. Two infertile groups were discriminated according to the pronuclei presence in IVF. The main outcome measure (pronuclei presence) was then correlated with lipid peroxidation product in semen (ROS effect). Although the average IL-8 levels and malondialdehyde (MDA) content in semen did not differ between the studied subgroups (successful vs. non-successful fertilization), a statistically significant negative correlation was found between MDA level and fertilization rate in performed regression analysis. Thus we may suggest that MDA levels in seminal plasma may have prognostic value for IVF success.

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Detection of interleukin-8 (IL-8) in seminal plasma and elevated IL-8 in seminal plasma of infertile patients with leukospermia

Cited by 72 publications

References 18 publications

Levels of interleukin-6 and interleukin-8 in seminal fluid of men attending an andrological clinic

Levels of interleukin-6 and interleukin-8 in seminal fluid of men attending an andrological clinic

Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility

Consequences of semen inflammation and lipid peroxidation on fertilization capacity of spermatozoa in in vitro conditions

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