DETECTION OFMYCOBACTERIUM AVIUMSUBSPECIESPARATUBERCULOSISIN ROCK HYRAXES (PROCAVIA CAPENSIS) IMPORTED FROM SOUTH AFRICA

Fechner, Kim; Schafer, James A.; Munster, P. J. J. Van; Ternes, Kerstin; Döring, Susanne; Völkel, Inger; Kaup, Franz‐Josef; Czerny, Claus-Peter

doi:10.1638/1042-7260-48.4.1086

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…The observed growth of MAP research in wildlife-related topics further support the existence of MAP infections in wild herds. Also, the possibility of zoonotic transmission of MAP from wild herds to domestic/zoological reserves’ herds and from either herd forms to humans could not be overemphasised [ 47 ] most especially, in countries (e.g., South Africa) where domestic herds and wild games are farmed together on the same piece of land. Some recent studies related to MAP infections in wild games include deer in Bulgaria and Chile [ 48 , 49 ], 34.4% incidence of MAP in Anas species (wild duck) populations in Korea [ 50 ], and wild-born Procavia capensis (rock hyraxes) imported from South Africa to Germany [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic Assessment of Mycobacterium avium Subspecies Paratuberculosis Infections from 1911–2019: A Growth Analysis of Association with Human Autoimmune Diseases

Ekundayo

Okoh

2020

Microorganisms

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Mycobacterium avium subsp. paratuberculosis (MAP) is an understudied pathogen worldwide with continuous implications in human autoimmune diseases (ADs). The awareness of MAP appears to be low in many places and its research is at infant stage in many countries. The lack of worldwide coverage of the MAP research landscape calls for urgent research attention and prioritization. This present study aimed to assess MAP global research productivity with an emphasis on its implications in ADs via bibliometric and growth analytic frameworks from authors, countries, institutions, international, disciplines and collaboration network perspectives. MAP primary articles were retrieved from the Scopus database and the Web of Science from 1911 to 2019 via title-specific algorithm. Analytic results of dataset yielded a total of 3889 articles from 581 journals and 20.65 average citations per documents. The annual growth rate of MAP research for the period was 6.31%. Based on a country’s productivity (articles (%), freq. of publication (%)), the USA (887 (22.81%), 26.72%), and Australia (236 (6.07%), 6.07%) ranked the top 2 countries but Egypt and Germany had the highest average growth rate (AGR, 170%) in the last 3 years. MAP studies are generally limited to Europe, Australia, Asia, South America and few nations in Africa. It had positive growth rate (30%–100%) in relation to type 1 diabetes mellitus and rheumatoid arthritis ADs; food science and technology, immunology, agriculture, pathology, and research and experimental medicine, wildlife, environments, virulence, disease resistance, meat and meat products, osteopontin, waste milk and slurry/sludge digestion subjects; but negative growth (−130% to −30%) in ulcerative colitis and Parkinson’s disease and no growth in multiple sclerosis, sarcoidosis, thyroid disorders, psoriasis, and lupus. The mapping revealed a gross lack of collaboration networking in terms of authorship, (intra- and inter-) nationally and institutionally with a generalized collaboration index of 1.82. In conclusion, inadequate resources-, knowledge- and scientific-networking hampered growth and awareness of MAP research globally. The study recommends further research to strengthen evidence of MAP’s epidemiologic prevalence in ADs and proffer practical solution(s) for drug development and point-of-care diagnostics amongst other extended themes.

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Section: Resultsmentioning

confidence: 99%

Systematic Assessment of Mycobacterium avium Subspecies Paratuberculosis Infections from 1911–2019: A Growth Analysis of Association with Human Autoimmune Diseases

Ekundayo

Okoh

2020

Microorganisms

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“…Although wildlife is very important in the economy of Sub-Saharan Africa, investigations of MAP in African wildlife have not been undertaken yet. Fechner et al [ 28 ] diagnosed MAP in hyraxes imported from South Africa to Germany, but no systematic investigation has been carried out on MAP infection in wildlife in Africa. Anecdotal records in Uganda indicate that lesions characteristic of MAP have been documented in an impala (Ojok, Personal communication).…”

Section: Paratuberculosis In Livestock and Wildlifementioning

confidence: 99%

Paratuberculosis: A Potential Zoonosis and a Neglected Disease in Africa

et al. 2020

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The Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of paratuberculosis, which is an economically important disease of ruminants. The zoonotic role of MAP in Crohn’s disease and, to a lesser extent, in ulcerative colitis, the two major forms of idiopathic inflammatory bowel disease (IIBD), has been debated for decades and evidence continues to mount in support of that hypothesis. The aim of this paper is to present a review of the current information on paratuberculosis in animals and the two major forms of IIBD in Africa. The occurrence, epidemiology, economic significance and “control of MAP and its involvement IIBD in Africa” are discussed. Although the occurrence of MAP is worldwide and has been documented in several African countries, the epidemiology and socioeconomic impacts remain undetermined and limited research information is available from the continent. At present, there are still significant knowledge gaps in all these areas as far as Africa is concerned. Due to the limited research on paratuberculosis in Africa, in spite of growing global concerns, it may rightfully be considered a neglected tropical disease with a potentially zoonotic role.

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“…Recently, a first report described MAP occurrence and infection in captive, wild-born rock hyraxes (Procavia capensis) and their captive-born offspring (147). Wild-born animals showed episodes of mild irregular diarrhea, but all routine parasitological and bacteriologic tests performed were negative.…”

Section: Hyracoidea Procaviidaementioning

confidence: 99%

Mycobacterium avium Subspecies paratuberculosis Infection in Zoo Animals: A Review of Susceptibility and Disease Process

et al. 2020

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Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of paratuberculosis (ParaTB or Johne's disease), a contagious, chronic and typically fatal enteric disease of domestic and non-domestic ruminants. Clinically affected animals present wasting and emaciation. However, MAP can also infect non-ruminant animal species with less specific signs. Zoological gardens harbor various populations of diverse animal species, which are managed on limited space at higher than natural densities. Hence, they are predisposed to endemic trans-species pathogen distribution. Information about the incidence and prevalence of MAP infections in zoological gardens and the resulting potential threat to exotic and endangered species are rare. Due to unclear pathogenesis, chronicity of disease as well as the unknown cross-species accuracy of diagnostic tests, diagnosis and surveillance of MAP and ParaTB is challenging. Differentiation between uninfected shedders of ingested bacteria; subclinically infected individuals; and preclinically diseased animals, which may subsequently develop clinical signs after long incubation periods, is crucial for the interpretation of positive test results in animals and the resulting consequences in their management. This review summarizes published data from the current literature on occurrence of MAP infection and disease in susceptible and affected zoo animal species as well as the applied diagnostic methods and measures. Clinical signs indicative for ParaTB, pathological findings and reports on detection, transmission and epidemiology in zoo animals are included. Furthermore, case reports were re-evaluated for incorporation into accepted consistent terminologies and case definitions.

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DETECTION OFMYCOBACTERIUM AVIUMSUBSPECIESPARATUBERCULOSISIN ROCK HYRAXES (PROCAVIA CAPENSIS) IMPORTED FROM SOUTH AFRICA

Cited by 6 publications

References 31 publications

Systematic Assessment of Mycobacterium avium Subspecies Paratuberculosis Infections from 1911–2019: A Growth Analysis of Association with Human Autoimmune Diseases

Systematic Assessment of Mycobacterium avium Subspecies Paratuberculosis Infections from 1911–2019: A Growth Analysis of Association with Human Autoimmune Diseases

Paratuberculosis: A Potential Zoonosis and a Neglected Disease in Africa

Mycobacterium avium Subspecies paratuberculosis Infection in Zoo Animals: A Review of Susceptibility and Disease Process

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