Detection of human papillomavirus in nongenital Bowen's disease by in situ DNA hybridization

Detection of Human Papillomavirus Type 58 in Polydactylous Bowen’s Disease on the Fingers and Toes of a Woman – Concurrent Occurrence of Invasive Vulval and Cervical Carcinomas

“…More recently, it has become evident that HPVs are causal for Bowen’s disease. It likely seems that genital HPVs, such as HPV-16 and HPV-35, induce Bowen’s disease [6, 7, 8, 13, 14, 15, 16, 17]. Like our present case, the same HPVs have been found both in Bowen’s disease on the skin and in the genital lesions of single patients [14, 15, 16, 17].…”

“…Although the mechanism of HPV-positive neoplasms, concomitantly developed on the hands and genitals, is not clear, it is supposed that the transmission of HPV via a genital-digital route may play an important role in the development of Bowen’s disease, and that scratching has resulted in autoinoculation from the genital area to the finger, as proposed by some authors [16]. Some authors maintain that HPV-related Bowen’s disease presents as verrucous or hypertrophic plaque rather than as erythematous or pigmented plaque [7]. Our patient displayed a variability in clinical expression.…”

Detection of Human Papillomavirus Type 58 in Polydactylous Bowen’s Disease on the Fingers and Toes of a Woman – Concurrent Occurrence of Invasive Vulval and Cervical Carcinomas

“…More recently, it has become evident that HPVs are causal for Bowen’s disease. It likely seems that genital HPVs, such as HPV-16 and HPV-35, induce Bowen’s disease [6, 7, 8, 13, 14, 15, 16, 17]. Like our present case, the same HPVs have been found both in Bowen’s disease on the skin and in the genital lesions of single patients [14, 15, 16, 17].…”

“…Although the mechanism of HPV-positive neoplasms, concomitantly developed on the hands and genitals, is not clear, it is supposed that the transmission of HPV via a genital-digital route may play an important role in the development of Bowen’s disease, and that scratching has resulted in autoinoculation from the genital area to the finger, as proposed by some authors [16]. Some authors maintain that HPV-related Bowen’s disease presents as verrucous or hypertrophic plaque rather than as erythematous or pigmented plaque [7]. Our patient displayed a variability in clinical expression.…”

Polydactylous Squamous Cell Carcinoma of the Nail Unit: A Structured Review of the Literature

“…A total of 45 polydactylous cases were identified through the literature review, including the 1 case seen by the authors in the clinic (Table 1). 4,6 -38 There was a clear male predominance with 73.9% of cases reported in males and 23.9% reported in females ( P < .005). The age range at diagnosis was 21-80 years, with a mean age of 48.7 years.…”

Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant

“…In the skin, Bowen's disease is associated with sun exposure, but in anal and genital region, high risk HPV genotypes are implicated in the etiology. [ 2 ]…”

Detection of Human Papillomavirus Type 58 in Polydactylous Bowen’s Disease on the Fingers and Toes of a Woman – Concurrent Occurrence of Invasive Vulval and Cervical Carcinomas

“…More recently, it has become evident that HPVs are causal for Bowen’s disease. It likely seems that genital HPVs, such as HPV-16 and HPV-35, induce Bowen’s disease [6, 7, 8, 13, 14, 15, 16, 17]. Like our present case, the same HPVs have been found both in Bowen’s disease on the skin and in the genital lesions of single patients [14, 15, 16, 17].…”

“…Although the mechanism of HPV-positive neoplasms, concomitantly developed on the hands and genitals, is not clear, it is supposed that the transmission of HPV via a genital-digital route may play an important role in the development of Bowen’s disease, and that scratching has resulted in autoinoculation from the genital area to the finger, as proposed by some authors [16]. Some authors maintain that HPV-related Bowen’s disease presents as verrucous or hypertrophic plaque rather than as erythematous or pigmented plaque [7]. Our patient displayed a variability in clinical expression.…”

Polydactylous Squamous Cell Carcinoma of the Nail Unit: A Structured Review of the Literature

“…A total of 45 polydactylous cases were identified through the literature review, including the 1 case seen by the authors in the clinic (Table 1). 4,6 -38 There was a clear male predominance with 73.9% of cases reported in males and 23.9% reported in females ( P < .005). The age range at diagnosis was 21-80 years, with a mean age of 48.7 years.…”

Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant

“…In the skin, Bowen's disease is associated with sun exposure, but in anal and genital region, high risk HPV genotypes are implicated in the etiology. [ 2 ]…”

Detection of Human Papillomavirus Type 58 in Polydactylous Bowen’s Disease on the Fingers and Toes of a Woman – Concurrent Occurrence of Invasive Vulval and Cervical Carcinomas

“…More recently, it has become evident that HPVs are causal for Bowen’s disease. It likely seems that genital HPVs, such as HPV-16 and HPV-35, induce Bowen’s disease [6, 7, 8, 13, 14, 15, 16, 17]. Like our present case, the same HPVs have been found both in Bowen’s disease on the skin and in the genital lesions of single patients [14, 15, 16, 17].…”

“…Although the mechanism of HPV-positive neoplasms, concomitantly developed on the hands and genitals, is not clear, it is supposed that the transmission of HPV via a genital-digital route may play an important role in the development of Bowen’s disease, and that scratching has resulted in autoinoculation from the genital area to the finger, as proposed by some authors [16]. Some authors maintain that HPV-related Bowen’s disease presents as verrucous or hypertrophic plaque rather than as erythematous or pigmented plaque [7]. Our patient displayed a variability in clinical expression.…”

Polydactylous Squamous Cell Carcinoma of the Nail Unit: A Structured Review of the Literature

“…A total of 45 polydactylous cases were identified through the literature review, including the 1 case seen by the authors in the clinic (Table 1). 4,6 -38 There was a clear male predominance with 73.9% of cases reported in males and 23.9% reported in females ( P < .005). The age range at diagnosis was 21-80 years, with a mean age of 48.7 years.…”

Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant

“…In the skin, Bowen's disease is associated with sun exposure, but in anal and genital region, high risk HPV genotypes are implicated in the etiology. [ 2 ]…”